Hormone levels and cognitive function in postmenopausal midlife women. - Archive ouverte HAL Access content directly
Journal Articles Neurobiology of Aging Year : 2012

Hormone levels and cognitive function in postmenopausal midlife women.

(1, 2) , (3) , (1) , (4) , (1) , (1) , (5) , (6)
1
2
3
4
5
6

Abstract

Gonadal hormones may influence cognitive function. Postmenopausal midlife women in the population-based Melbourne Women's Midlife Health Project cohort were administered a comprehensive battery of neuropsychological tests on two occasions 2 years apart. Participants (n = 148, mean age 60 years) had undergone natural menopause and were not using hormone therapy. Estrone, total and free estradiol, and total and free testosterone levels were measured at time of the first testing. Principal-component analysis identified four cognitive factors. In multiple linear regression analyses, better semantic memory performance was associated with higher total (p = 0.02) and free (p = 0.03) estradiol levels and a lower ratio of testosterone to estradiol (p = 0.007). There were trends for associations between better verbal episodic memory and lower total testosterone (p = 0.08) and lower testosterone/estradiol ratio (p = 0.06). Lower free testosterone levels were associated with greater 2-year improvement on verbal episodic memory (p = 0.04); higher testosterone/estradiol predicted greater semantic memory improvement (p = 0.03). In postmenopausal midlife women, endogenous estradiol and testosterone levels and the testosterone/estradiol ratio are associated with semantic memory and verbal episodic memory abilities.
Fichier principal
Vignette du fichier
Ryan_Neurobiol_Aging_33_1138.pdf (311.28 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-00860997 , version 1 (11-09-2013)

Identifiers

Cite

Joanne Ryan, Frank Z. Stanczyk, Lorraine Dennerstein, Wendy J. Mack, Margaret S. Clark, et al.. Hormone levels and cognitive function in postmenopausal midlife women.. Neurobiology of Aging, 2012, 33 (7), pp.1138-47. ⟨10.1016/j.neurobiolaging.2012.04.011⟩. ⟨inserm-00860997⟩
269 View
929 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More