Skip to Main content Skip to Navigation
Journal articles

Hormone levels and cognitive function in postmenopausal midlife women.

Abstract : Gonadal hormones may influence cognitive function. Postmenopausal midlife women in the population-based Melbourne Women's Midlife Health Project cohort were administered a comprehensive battery of neuropsychological tests on two occasions 2 years apart. Participants (n = 148, mean age 60 years) had undergone natural menopause and were not using hormone therapy. Estrone, total and free estradiol, and total and free testosterone levels were measured at time of the first testing. Principal-component analysis identified four cognitive factors. In multiple linear regression analyses, better semantic memory performance was associated with higher total (p = 0.02) and free (p = 0.03) estradiol levels and a lower ratio of testosterone to estradiol (p = 0.007). There were trends for associations between better verbal episodic memory and lower total testosterone (p = 0.08) and lower testosterone/estradiol ratio (p = 0.06). Lower free testosterone levels were associated with greater 2-year improvement on verbal episodic memory (p = 0.04); higher testosterone/estradiol predicted greater semantic memory improvement (p = 0.03). In postmenopausal midlife women, endogenous estradiol and testosterone levels and the testosterone/estradiol ratio are associated with semantic memory and verbal episodic memory abilities.
Complete list of metadata

Cited literature [65 references]  Display  Hide  Download
Contributor : Dominique Villebrun Connect in order to contact the contributor
Submitted on : Wednesday, September 11, 2013 - 4:09:49 PM
Last modification on : Tuesday, March 15, 2022 - 9:31:55 AM
Long-term archiving on: : Thursday, April 6, 2017 - 6:19:24 PM


Files produced by the author(s)




Joanne Ryan, Frank Z. Stanczyk, Lorraine Dennerstein, Wendy J. Mack, Margaret S. Clark, et al.. Hormone levels and cognitive function in postmenopausal midlife women.. Neurobiology of Aging, Elsevier, 2012, 33 (7), pp.1138-47. ⟨10.1016/j.neurobiolaging.2012.04.011⟩. ⟨inserm-00860997⟩



Record views


Files downloads