P. Damier, E. Hirsch, Y. Agid, and A. Graybiel, The substantia nigra of the human brain: II. Patterns of loss of dopamine-containing neurons in Parkinson's disease, Brain, vol.122, issue.8, pp.1437-1448, 1999.
DOI : 10.1093/brain/122.8.1437

T. Nagatsu and M. Sawada, Biochemistry of postmortem brains in Parkinson???s disease: historical overview and future prospects, J. Neural. Transm. Suppl, vol.72, pp.113-120, 2007.
DOI : 10.1007/978-3-211-73574-9_14

S. Haber, The primate basal ganglia: parallel and integrative networks, Journal of Chemical Neuroanatomy, vol.26, issue.4, pp.317-330, 2003.
DOI : 10.1016/j.jchemneu.2003.10.003

B. Liss, O. Haeckel, J. Wildmann, T. Miki, S. Seino et al., K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons, Nature Neuroscience, vol.20, issue.12, pp.1742-1751, 2005.
DOI : 10.1038/nn1570

A. Lees, The Parkinson chimera, Neurology, vol.72, issue.Issue 7, Supplement 2, pp.2-11, 2009.
DOI : 10.1212/WNL.0b013e318198daec

J. Fudge, K. Kunishio, C. Walsh, D. Richard, and S. Haber, Amygdaloid projections to ventromedial striatal subterritories in the primate, Neuroscience, vol.110, issue.2, pp.257-275, 2002.
DOI : 10.1016/S0306-4522(01)00546-2

A. Flaherty and A. Graybiel, Input-output organization of the sensorimotor striatum in the squirrel monkey, J. Neurosci, vol.14, pp.599-610, 1994.

N. Mcfarland and S. Haber, Convergent inputs from thalamic motor nuclei and frontal cortical areas to the dorsal striatum in the primate, J. Neurosci, vol.20, pp.3798-3813, 2000.

C. Chassain, G. Bielicki, E. Durand, S. Lolignier, F. Essafi et al., Metabolic changes detected by proton magnetic resonance spectroscopy in vivo and in vitro in a murin model of Parkinson???s disease, the MPTP-intoxicated mouse, Journal of Neurochemistry, vol.57, issue.3, pp.874-882, 2008.
DOI : 10.1016/j.neuroscience.2005.06.067

C. Chassain, G. Bielicki, C. Keller, J. Renou, and F. Durif, Metabolic changes detected in vivo by 1H MRS in the MPTP-intoxicated mouse, NMR in Biomedicine, vol.136, issue.6, pp.547-563, 2010.
DOI : 10.1002/nbm.1504

URL : https://hal.archives-ouvertes.fr/hal-01005082

R. Heikkila, A. Hess, and R. Duvoisin, Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice, Science, vol.224, issue.4656, pp.1451-1453, 1984.
DOI : 10.1126/science.6610213

O. Hornykiewicz, Biochemical aspects of Parkinson's disease, Neurology, vol.51, issue.Issue 2, Supplement 2, pp.2-9, 1998.
DOI : 10.1212/WNL.51.2_Suppl_2.S2

R. Cilia, J. Ko, S. Cho, T. Van-eimeren, G. Marotta et al., Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling, Neurobiology of Disease, vol.39, issue.1, pp.98-104, 2010.
DOI : 10.1016/j.nbd.2010.03.013

S. Yagi, E. Yoshikawa, M. Futatsubashi, M. Yokokura, Y. Yoshihara et al., Progression from Unilateral to Bilateral Parkinsonism in Early Parkinson Disease: Implication of Mesocortical Dopamine Dysfunction by PET, Journal of Nuclear Medicine, vol.51, issue.8, pp.1250-1257, 2010.
DOI : 10.2967/jnumed.110.076802

N. Ogawa, Y. Hirose, S. Ohara, T. Ono, and Y. Watanabe, A simple quantitative bradykinesia test in MPTP-treated mice, Res. Comm. Chem. Pathol. Pharmacol, vol.50, pp.435-441, 1985.

I. Tkac, P. Henry, P. Andersen, C. Keene, W. Low et al., H NMR spectroscopy of the mouse brain at 9.4 T, Magnetic Resonance in Medicine, vol.49, issue.3, pp.478-484, 2004.
DOI : 10.1002/mrm.20184

K. Behar and T. Ogino, Characterization of macromolecule resonances in the1H NMR spectrum of rat brain, Magnetic Resonance in Medicine, vol.82, issue.1, pp.38-44, 1993.
DOI : 10.1002/mrm.1910300107

J. Pfeuffer, I. Tkác, S. Provencher, and R. Gruetter, Toward an in Vivo Neurochemical Profile: Quantification of 18 Metabolites in Short-Echo-Time 1H NMR Spectra of the Rat Brain, Journal of Magnetic Resonance, vol.141, issue.1
DOI : 10.1006/jmre.1999.1895

H. Agrawal, J. Davis, and W. Himwich, DEVELOPMENTAL CHANGES IN MOUSE BRAIN: WEIGHT, WATER CONTENT AND FREE AMINO ACIDS, Journal of Neurochemistry, vol.3, issue.170, pp.917-923, 1968.
DOI : 10.1111/j.1471-4159.1968.tb11633.x

M. Papadopoulos, G. Manley, S. Krishna, and A. Verkman, Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. The FASEB, pp.1291-1293, 2004.

S. Provencher, Estimation of metabolite concentrations from localizedin vivo proton NMR spectra, Magnetic Resonance in Medicine, vol.10, issue.6, pp.672-679, 1993.
DOI : 10.1002/mrm.1910300604

S. Cavassila, S. Deval, C. Huegen, D. Van-ormondt, and D. Graveron-demilly, Cram??r-Rao bounds: an evaluation tool for quantitation, NMR in Biomedicine, vol.59, issue.2, pp.278-283, 2001.
DOI : 10.1002/nbm.701

D. S. Zahm, Functional-anatomical Implications of the Nucleus Accumbens Core and Shell Subterritories, Annals of the New York Academy of Sciences, vol.15, issue.1 ADVANCING FRO, pp.113-141, 1999.
DOI : 10.1016/0361-9230(95)02030-2

N. Jonkers, S. Sarre, G. Ebinger, and Y. Michotte, MK801 suppresses the l-DOPA-induced increase of glutamate in striatum of hemi-Parkinson rats, Brain Research, vol.926, issue.1-2, pp.149-155, 2002.
DOI : 10.1016/S0006-8993(01)03147-X

B. Lavoie, A. Parent, and P. Bedard, ABSTRACT:, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, vol.219, issue.S3, pp.373-375, 1991.
DOI : 10.1002/cne.902990102

K. Gnanalingham, L. Smith, A. Hunter, P. Jenner, and C. Marsden, Alterations in striatal and extrastriatal D-1 and D-2 dopamine receptors in the MPTP-treated common marmoset: An autoradiographic study, Synapse, vol.23, issue.2, pp.184-194, 1993.
DOI : 10.1002/syn.890140212

. Phani-s, G. Gonye, and L. Iacovitti, VTA neurons show a potentially protective transcriptional response to MPTP, Brain Research, vol.1343, pp.1-13, 2010.
DOI : 10.1016/j.brainres.2010.04.061

J. Hernandez, Vulnerability of mesostriatal dopaminergic neurons in Parkinson's disease, Front. Neuroanat, vol.4, pp.140-154, 2010.

P. Anglade, A. Mouatt-prigent, Y. Agid, and E. Hirsch, Synaptic Plasticity in the Caudate Nucleus of Patients with Parkinson's Disease, Neurodegeneration, vol.5, issue.2, pp.121-128, 1996.
DOI : 10.1006/neur.1996.0018

C. Ingham, S. Hood, P. Taggart, and G. Arbuthnott, Plasticity of synapses in the rat neostriatum after unilateral lesion of the nigrostriatal dopaminergic pathway, J. Neurosci, vol.18, pp.4732-4743, 1998.

C. Meshul, N. Emre, C. Nakamura, C. Allen, M. Donohue et al., Time-dependent changes in striatal glutamate synapses following a 6-hydroxydopamine lesion, Neuroscience, vol.88, issue.1, pp.1-16, 1999.
DOI : 10.1016/S0306-4522(98)00189-4

R. Walker, R. Koch, J. Sweeney, C. Moore, and C. Meshul, Effects of subthalamic nucleus lesions and stimulation upon glutamate levels in the dopamine-depleted rat striatum, NeuroReport, vol.20, issue.8, pp.770-775, 2009.
DOI : 10.1097/WNR.0b013e32832ad556

J. Litwak, M. Mercugliano, M. Chesselet, and G. Olman, Increased glutamic acid decarboxylase (GAD) mRNA and GAD activity in cerebellar Purkinje cells following lesion-induced increases in cell firing, Neuroscience Letters, vol.116, issue.1-2, pp.179-183, 1990.
DOI : 10.1016/0304-3940(90)90406-Y

J. Soghomonian and D. Martin, Two isoforms of glutamate decarboxylase: why?, Trends in Pharmacological Sciences, vol.19, issue.12, pp.500-505, 1998.
DOI : 10.1016/S0165-6147(98)01270-X

P. Calabresi, N. Mercuri, G. Sancesario, and G. Bemardi, Electrophysiology of dopaminedenervated striatal neurons. Implication for Parkinson's disease, Brain, vol.11, pp.433-452, 1993.

N. Lindefors, E. Brodin, U. Tossman, H. Segovia, and U. Ungerstedt, Tissue levels and in vivo release of tachychinins and GABA in striatum and substantia nigra of rat brain after unilateral striatal dopamine denervation, Exp. Brain. Res, vol.74, pp.527-534, 2003.

A. Carta, S. Fenu, P. Pala, E. Tronci, and M. Morelli, Selective modifications in GAD67 mRNA levels in striatonigral and striatopallidal pathways correlate to dopamine agonist priming in 6-hydroxydopamine-lesioned rats, European Journal of Neuroscience, vol.83, issue.9, pp.2563-2572, 2003.
DOI : 10.1016/0006-8993(87)91149-8

D. Bergles and C. Jahr, Synaptic Activation of Glutamate Transporters in Hippocampal Astrocytes, Neuron, vol.19, issue.6, pp.1297-1308, 1997.
DOI : 10.1016/S0896-6273(00)80420-1

N. Sibson, A. Dhankhar, G. Mason, D. Rothman, K. Behar et al., Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity, Proc. Natl. Acad
DOI : 10.1073/pnas.95.1.316

P. Magistretti, L. Pellerin, D. Rothman, and R. Shulman, NEUROSCIENCE:Energy on Demand, Science, vol.283, issue.5401, pp.496-497, 1999.
DOI : 10.1126/science.283.5401.496

R. Gruetter, In vivo 13C NMR studies of compartmentalized cerebral carbohydrate metabolism, Neurochemistry International, vol.41, issue.2-3, pp.143-154, 2002.
DOI : 10.1016/S0197-0186(02)00034-7

J. Yang and J. Shen, In vivo evidence for reduced cortical glutamate???glutamine cycling in rats treated with the antidepressant/antipanic drug phenelzine, Neuroscience, vol.135, issue.3, pp.927-937, 2005.
DOI : 10.1016/j.neuroscience.2005.06.067