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Quantitative mapping of angiogenesis by magnetic resonance imaging

Teodora-Adriana Perles-Barbacaru 1 Hana Lahrech 1, *
* Corresponding author
1 Inserm U836, équipe 7, Nanomédecine et cerveau
GIN - Grenoble Institut des Neurosciences
Abstract : This chapter focuses on MRI techniques for angiogenesis assessment. In particular it describes a newly developed quantitative MRI technique for in vivo blood volume fraction mapping for preclinical and above all for clinical applications in neurooncology. The blood volume fraction is a biomarker for angiogenesis and has proven successful in mapping brain dysfunction and in testing drug efficacy. The described technique is compared with other magnetic resonance imaging techniques currently employed in the preclinical and clinical setting. Therefore, this chapter provides an overview of existing quantitative MRI techniques, briefly explains their basic principle, states their acquisition and postprocessing requirements, and compares their advantages and limits. Quantitative results for blood volume fraction measures in laboratory animals and human subjects are presented and compared. Pitfalls and possibilities in neurooncological applications are pointed out and discussed.
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Submitted on : Wednesday, September 4, 2013 - 3:34:07 PM
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  • HAL Id : inserm-00858075, version 1

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Teodora-Adriana Perles-Barbacaru, Hana Lahrech. Quantitative mapping of angiogenesis by magnetic resonance imaging. Functional Brain Mapping and the Endeavor to Understand the Working Brain, InTech, pp.457-511, 2013. ⟨inserm-00858075⟩

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