Highly accelerated dynamic contrast enhanced imaging.

Robert Marc Lebel 1 Jesse Jones 2 Jean-Christophe Ferré 3, 2 Meng Law 2 Krishna S Nayak 1
3 VisAGeS - Vision, Action et Gestion d'informations en Santé
INSERM - Institut National de la Santé et de la Recherche Médicale : U746, Inria Rennes – Bretagne Atlantique , IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE
Abstract : PURPOSE: Dynamic contrast-enhanced imaging provides unique physiological information, notably the endothelial permeability (K(trans) ), and may improve the diagnosis and management of multiple pathologies. Current acquisition methods provide limited spatial-temporal resolution and field-of-view, often preventing characterization of the entire pathology and precluding measurement of the arterial input function. We present a method for highly accelerated dynamic imaging and demonstrate its utility for dynamic contrast-enhanced modeling. METHODS: We propose a novel Poisson ellipsoid sampling scheme and enforce multiple spatial and temporal l1 -norm constraints during image reconstruction. Retrospective and prospective analyses were performed to validate the approach. RESULTS: Retrospectively, no mean bias or diverging trend was observed as the acceleration rate was increased from 3× to 18×; less than 10% error was measured in K(trans) at any individual rates in this range. Prospectively accelerated images at a rate of 36× enabled full brain coverage with 0.94 × 0.94 × 1.9 mm(3) spatial and 4.1 s temporal resolutions. Images showed no visible degradation and provided accurate K(trans) values when compared to a clinical population. CONCLUSION: Highly accelerated dynamic MRI using compressed sensing and parallel imaging provides accurate permeability modeling and enables full brain, high resolution acquisitions. Magn Reson Med 000:000-000, 2013. © 2013 Wiley Periodicals, Inc.
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Magnetic Resonance in Medicine, Wiley, 2013, epub ahead of print. 〈10.1002/mrm.24710〉
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http://www.hal.inserm.fr/inserm-00857170
Contributeur : Jean-Christophe Ferré <>
Soumis le : lundi 2 septembre 2013 - 18:57:04
Dernière modification le : mercredi 16 mai 2018 - 11:23:11

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Robert Marc Lebel, Jesse Jones, Jean-Christophe Ferré, Meng Law, Krishna S Nayak. Highly accelerated dynamic contrast enhanced imaging.. Magnetic Resonance in Medicine, Wiley, 2013, epub ahead of print. 〈10.1002/mrm.24710〉. 〈inserm-00857170〉

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