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Highly accelerated dynamic contrast enhanced imaging.

Robert Marc Lebel 1 Jesse Jones 2 Jean-Christophe Ferré 3, 2 Meng Law 2 Krishna S Nayak 1 
3 VisAGeS - Vision, Action et Gestion d'informations en Santé
INSERM - Institut National de la Santé et de la Recherche Médicale : U746, Inria Rennes – Bretagne Atlantique , IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE
Abstract : PURPOSE: Dynamic contrast-enhanced imaging provides unique physiological information, notably the endothelial permeability (K(trans) ), and may improve the diagnosis and management of multiple pathologies. Current acquisition methods provide limited spatial-temporal resolution and field-of-view, often preventing characterization of the entire pathology and precluding measurement of the arterial input function. We present a method for highly accelerated dynamic imaging and demonstrate its utility for dynamic contrast-enhanced modeling. METHODS: We propose a novel Poisson ellipsoid sampling scheme and enforce multiple spatial and temporal l1 -norm constraints during image reconstruction. Retrospective and prospective analyses were performed to validate the approach. RESULTS: Retrospectively, no mean bias or diverging trend was observed as the acceleration rate was increased from 3× to 18×; less than 10% error was measured in K(trans) at any individual rates in this range. Prospectively accelerated images at a rate of 36× enabled full brain coverage with 0.94 × 0.94 × 1.9 mm(3) spatial and 4.1 s temporal resolutions. Images showed no visible degradation and provided accurate K(trans) values when compared to a clinical population. CONCLUSION: Highly accelerated dynamic MRI using compressed sensing and parallel imaging provides accurate permeability modeling and enables full brain, high resolution acquisitions. Magn Reson Med 000:000-000, 2013. © 2013 Wiley Periodicals, Inc.
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Submitted on : Monday, September 2, 2013 - 6:57:04 PM
Last modification on : Tuesday, April 19, 2022 - 10:17:09 AM

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Robert Marc Lebel, Jesse Jones, Jean-Christophe Ferré, Meng Law, Krishna S Nayak. Highly accelerated dynamic contrast enhanced imaging.. Magnetic Resonance in Medicine, Wiley, 2013, epub ahead of print. ⟨10.1002/mrm.24710⟩. ⟨inserm-00857170⟩



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