A water soluble probe with near infrared two-photon absorption and polarity-induced fluorescence for cerebral vascular imaging

Julien Massin; Azzam Charaf-Eddin; Florence Appaix; Yann Bretonnière; Denis Jacquemin; Boudewijn Van Der Sanden; Cyrille Monnereau; Chantal Andraud

A water soluble probe with near infrared two-photon absorption and polarity-induced fluorescence for cerebral vascular imaging

Julien Massin ¹ Azzam Charaf-Eddin ² Florence Appaix ³ Yann Bretonnière ¹ Denis Jacquemin ^{2, 4, *} Boudewijn Van Der Sanden ⁵ Cyrille Monnereau ¹ Chantal Andraud ¹

* Auteur correspondant

1 LC - Laboratoire de Chimie - UMR5182

2 CEISAM - Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation

3 GIN - Grenoble Institut des Neurosciences

4 Service Chimie

5 Inserm U836, équipe 7, Nanomédecine et cerveau

GIN - Grenoble Institut des Neurosciences

Abstract : A water soluble Lemke chromophore derivative shows an unusual polarity dependence of its emission efficiency, leading to strong red-NIR fluorescence in water when fitted with appropriate water-solubilizing polymer chains. In this edge article, the synthesis of the chromophore is described. The dependence of its fluorescence on solvent polarity is investigated experimentally and rationalized on the basis of ab initio calculations. Finally, we demonstrate that this chromophore is a valuable candidate for in vivo two-photon imaging of cerebral vasculature, with two-photon absorption and emission in the biological transparency window.

Type de document :

Article dans une revue

Chem. Sci., 2013, 4 (7), pp.2833-2843

Domaine :

Sciences du Vivant [q-bio] / Biotechnologies

Informatique [cs] / Biotechnologie

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Littérature citée [37 références] Voir Masquer Télécharger

http://www.hal.inserm.fr/inserm-00856213
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