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Statistics of acoustically induced bubble-nucleation events in in vitro blood: a feasibility study.

Jérôme Gateau 1, 2, * Nicolas Taccoen 1, 2 Mickaël Tanter 1, 2 Jean-François Aubry 1, 2
* Corresponding author
1 Physique des ondes pour la médecine
ESPCI Paris - Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris, INSERM - Institut National de la Santé et de la Recherche Médicale : U979, CNRS - Centre National de la Recherche Scientifique : UMR7587
Abstract : Bubbles can form in biological tissues through ultrasonic activation of natural gas nuclei. The damaging aftereffects raise safety concerns. However, the population of nuclei is currently unknown, and bubble nucleation is stochastic and thus unpredictable. This study investigates the statistical behavior of bubble nucleation experimentally and introduces a model-based analysis to determine the distribution of nuclei in biological samples-two pig blood samples in vitro. Combined ultra-fast passive and active cavitation detection with a linear array was used to detect nucleation from pulsed ultrasound excitations at 660 kHz. Single nucleation events were detected at peak rarefaction pressures from -3.6 to -24 MPa, and the nucleation probability over the range 0 to 1 was estimated from more than 330 independent acquisitions per sample. Model fitting of the experimental probability revealed that the distribution of nuclei is most likely continuous, and nuclei are rare in comparison to blood cells.
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Submitted on : Monday, August 26, 2013 - 10:40:57 PM
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Jérôme Gateau, Nicolas Taccoen, Mickaël Tanter, Jean-François Aubry. Statistics of acoustically induced bubble-nucleation events in in vitro blood: a feasibility study.. Ultrasound in Medicine & Biology, Elsevier, 2013, 39 (10), pp.1812-25. ⟨10.1016/j.ultrasmedbio.2013.04.011⟩. ⟨inserm-00854363⟩

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