Statistics of acoustically induced bubble-nucleation events in in vitro blood: a feasibility study.

Jérôme Gateau 1, * Nicolas Taccoen 1 Mickaël Tanter 1 Jean-François Aubry 1
* Auteur correspondant
1 Physique des ondes pour la médecine
Abstract : Bubbles can form in biological tissues through ultrasonic activation of natural gas nuclei. The damaging aftereffects raise safety concerns. However, the population of nuclei is currently unknown, and bubble nucleation is stochastic and thus unpredictable. This study investigates the statistical behavior of bubble nucleation experimentally and introduces a model-based analysis to determine the distribution of nuclei in biological samples-two pig blood samples in vitro. Combined ultra-fast passive and active cavitation detection with a linear array was used to detect nucleation from pulsed ultrasound excitations at 660 kHz. Single nucleation events were detected at peak rarefaction pressures from -3.6 to -24 MPa, and the nucleation probability over the range 0 to 1 was estimated from more than 330 independent acquisitions per sample. Model fitting of the experimental probability revealed that the distribution of nuclei is most likely continuous, and nuclei are rare in comparison to blood cells.
Keywords : cavitation bubble blood nucleation probability ultrasound detection passive imaging ultrafast imaging model-based analysis
Type de document :
Article dans une revue
Ultrasound in Medicine and Biology, Elsevier, 2013, 39 (10), pp.1812-25. 〈10.1016/j.ultrasmedbio.2013.04.011〉
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Soumis le : lundi 26 août 2013 - 22:40:57
Dernière modification le : jeudi 11 janvier 2018 - 06:23:18
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Jérôme Gateau, Nicolas Taccoen, Mickaël Tanter, Jean-François Aubry. Statistics of acoustically induced bubble-nucleation events in in vitro blood: a feasibility study.. Ultrasound in Medicine and Biology, Elsevier, 2013, 39 (10), pp.1812-25. 〈10.1016/j.ultrasmedbio.2013.04.011〉. 〈inserm-00854363〉

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