Corticospinal tract asymmetry and handedness in right- and left-handers by diffusion tensor tractography: Corticospinal tract asymmetry and handedness

Romuald Seizeur 1, 2, * Elsa Magro 1 Sylvain Prima 3 Nicolas Wiest-Daesslé 3 Camille Maumet 3 Xavier Morandi 4
* Corresponding author
1 Service de neurochirurgie [Brest]
2 Optimisation Continue des Actions Thérapeutiques par l'Intégration d'Informations Multimodales
3 VisAGeS - Vision, Action et Gestion d'informations en Santé
INSERM - Institut National de la Santé et de la Recherche Médicale : U746, Inria Rennes – Bretagne Atlantique , IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE
4 LTSI - Laboratoire Traitement du Signal et de l'Image
Abstract : PURPOSE: Cerebral hemispheres represent both structural and functional asymmetry, which differs among right- and left-handers. The left hemisphere is specialised for language and task execution of the right hand in right-handers. We studied the corticospinal tract in right- and left-handers by diffusion tensor imaging and tractography. The present study aimed at revealing a morphological difference resulting from a region of interest (ROI) obtained by functional MRI (fMRI). METHODS: Twenty-five healthy participants (right-handed: 15, left-handed: 10) were enrolled in our assessment of morphological, functional and diffusion tensor MRI. Assessment of brain fibre reconstruction (tractography) was done using a deterministic algorithm. Fractional anisotropy (FA) and mean diffusivity (MD) were studied on the tractography traces of the reference slices. RESULTS: We observed a significant difference in number of leftward fibres based on laterality. The significant difference in regard to FA and MD was based on the slices obtained at different levels and the laterality index. We found left-hand asymmetry and right-hand asymmetry, respectively, for the MD and FA. CONCLUSIONS: Our study showed the presence of hemispheric asymmetry based on laterality index in right- and left-handers. These results are inconsistent with some studies and consistent with others. The reported difference in hemispheric asymmetry could be related to dexterity (manual skill).
Keywords : MRI anatomy corticospinal tract deterministic tractography diffusion tensor imaging
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Romuald Seizeur, Elsa Magro, Sylvain Prima, Nicolas Wiest-Daesslé, Camille Maumet, et al.. Corticospinal tract asymmetry and handedness in right- and left-handers by diffusion tensor tractography: Corticospinal tract asymmetry and handedness. Surgical and Radiologic Anatomy, Springer Verlag (Germany), 2013, 36 (2), pp.111-124. ⟨10.1007/s00276-013-1156-7⟩. ⟨inserm-00853861⟩

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