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Apelin stimulates both cholecystokinin and glucagon-like peptide 1 secretions in vitro and in vivo in rodents.

Abstract : Apelin is an enteric peptide that exerts several digestive functions such as stimulation of cell proliferation and cholecystokinin (CCK) secretion. We investigated using murine enteroendocrine cell line (STC-1) and rats if apelin-13 stimulates both CCK and glucagon-like peptide 1 (GLP-1) secretions. We demonstrated that, in vitro and in vivo, apelin-13 increases the release of these two hormones in a dose-dependent manner. Present data suggest that apelin may modulate digestive functions, food intake behavior and glucose homoeostasis via apelin-induced release of enteric CCK but also through a new incretin-releasing activity on enteric GLP-1.
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https://www.hal.inserm.fr/inserm-00853168
Contributor : Marie Francoise Simon <>
Submitted on : Thursday, August 22, 2013 - 9:49:43 AM
Last modification on : Friday, January 10, 2020 - 9:09:54 PM

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Jean-Sébastien Wattez, Rozenn Ravallec, Benoit Cudennec, Claude Knauf, Pascal Dhulster, et al.. Apelin stimulates both cholecystokinin and glucagon-like peptide 1 secretions in vitro and in vivo in rodents.. Peptides, Elsevier, 2013, epub ahead of print. ⟨10.1016/j.peptides.2013.08.005⟩. ⟨inserm-00853168⟩

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