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Journal articles
Identification of a novel BET bromodomain inhibitor-sensitive, gene regulatory circuit that controls Rituximab response and tumour growth in aggressive lymphoid cancers.: CYCLON-induced Rituximab resistance
Abstract : Immuno-chemotherapy elicit high response rates in B-cell non-Hodgkin lymphoma but heterogeneity in response duration is observed, with some patients achieving cure and others showing refractory disease or relapse. Using a transcriptome-powered targeted proteomics screen, we discovered a gene regulatory circuit involving the nuclear factor CYCLON which characterizes aggressive disease and resistance to the anti-CD20 monoclonal antibody, Rituximab, in high-risk B-cell lymphoma. CYCLON knockdown was found to inhibit the aggressivity of MYC-overexpressing tumours in mice and to modulate gene expression programs of biological relevance to lymphoma. Furthermore, CYCLON knockdown increased the sensitivity of human lymphoma B cells to Rituximab in vitro and in vivo. Strikingly, this effect could be mimicked by in vitro treatment of lymphoma B cells with a small molecule inhibitor for BET bromodomain proteins (JQ1). In summary, this work has identified CYCLON as a new MYC cooperating factor that autonomously drives aggressive tumour growth and Rituximab resistance in lymphoma. This resistance mechanism is amenable to next-generation epigenetic therapy by BET bromodomain inhibition, thereby providing a new combination therapy rationale for high-risk lymphoma.
Cited literature [65 references]
https://www.hal.inserm.fr/inserm-00852222
Contributor : Samuel Duley <>
Submitted on : Tuesday, August 20, 2013 - 11:55:25 AM
Last modification on : Wednesday, October 14, 2020 - 4:18:49 AM
Long-term archiving on: : Thursday, November 21, 2013 - 4:14:00 AM
Contributor : Samuel Duley <>
Submitted on : Tuesday, August 20, 2013 - 11:55:25 AM
Last modification on : Wednesday, October 14, 2020 - 4:18:49 AM
Long-term archiving on: : Thursday, November 21, 2013 - 4:14:00 AM
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emmm201202034.pdf
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