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Individual patient data systematic review and meta-analysis of optic nerve sheath diameter ultrasonography for detecting raised intracranial pressure: protocol of the ONSD research group.

Julie Dubourg 1, * Mahmoud Messerer 2 Dimitrios Karakitsos 3 Venkatakrishna Rajajee 4 Erik Antonsen 5 Etienne Javouhey 6 Alessandro Cammarata 7 Michael Cotton 8 Roy Daniel 2 Carmelo Denaro 9 Emmanuel Douzinas 10 Clément Dubost 11 Moncef Berhouma 12 Behrouz Kassai 13, 14 Muriel Rabilloud 15, 16 Antonino Gullo 17 Abderrhammane Hamlat 18 Gregorios Kouraklis 19 Giuseppe Mannanici 7 Keith Marill 20 Sybille Merceron 21 John Poularas 3 Giuseppe Ristagno 22 Vicki Noble 20 Sachita Shah 23 Heidi Kimberly 20 Gianluca Cammarata 9 Riccardo Moretti 24 Thomas Geeraerts 25
Abstract : BACKGROUND: The purpose of the optic nerve sheath diameter (ONSD) research group project is to establish an individual patient-level database from high quality studies of ONSD ultrasonography for the detection of raised intracranial pressure (ICP), and to perform a systematic review and an individual patient data meta-analysis (IPDMA), which will provide a cutoff value to help physicians making decisions and encourage further research. Previous meta-analyses were able to assess the diagnostic accuracy of ONSD ultrasonography in detecting raised ICP but failed to determine a precise cutoff value. Thus, the ONSD research group was founded to synthesize data from several recent studies on the subject and to provide evidence on the diagnostic accuracy of ONSD ultrasonography in detecting raised ICP. METHODS: This IPDMA will be conducted in different phases. First, we will systematically search for eligible studies. To be eligible, studies must have compared ONSD ultrasonography to invasive intracranial devices, the current reference standard for diagnosing raised ICP. Subsequently, we will assess the quality of studies included based on the QUADAS-2 tool, and then collect and validate individual patient data. The objectives of the primary analyses will be to assess the diagnostic accuracy of ONSD ultrasonography and to determine a precise cutoff value for detecting raised ICP. Secondly, we will construct a logistic regression model to assess whether patient and study characteristics influence diagnostic accuracy. DISCUSSION: We believe that this IPD MA will provide the most reliable basis for the assessment of diagnostic accuracy of ONSD ultrasonography for detecting raised ICP and to provide a cutoff value. We also hope that the creation of the ONSD research group will encourage further study. TRIAL REGISTRATION: PROSPERO registration number: CRD42012003072.
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Julie Dubourg, Mahmoud Messerer, Dimitrios Karakitsos, Venkatakrishna Rajajee, Erik Antonsen, et al.. Individual patient data systematic review and meta-analysis of optic nerve sheath diameter ultrasonography for detecting raised intracranial pressure: protocol of the ONSD research group.. Systematic Reviews, BioMed Central, 2013, 2 (1), pp.62. ⟨10.1186/2046-4053-2-62⟩. ⟨inserm-00851700⟩

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