Individual patient data systematic review and meta-analysis of optic nerve sheath diameter ultrasonography for detecting raised intracranial pressure: protocol of the ONSD research group. - Archive ouverte HAL Access content directly
Journal Articles Systematic Reviews Year : 2013

Individual patient data systematic review and meta-analysis of optic nerve sheath diameter ultrasonography for detecting raised intracranial pressure: protocol of the ONSD research group.

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Mahmoud Messerer
  • Function : Author
  • PersonId : 944477
Dimitrios Karakitsos
  • Function : Author
  • PersonId : 944478
Alessandro Cammarata
  • Function : Author
  • PersonId : 944481
Michael Cotton
  • Function : Author
  • PersonId : 944482
Roy Thomas Daniel
  • Function : Author
  • PersonId : 944483
Carmelo Denaro
  • Function : Author
  • PersonId : 944484
Emmanuel Douzinas
  • Function : Author
  • PersonId : 944485
Clément Dubost
  • Function : Author
  • PersonId : 944486
Moncef Berhouma
  • Function : Author
  • PersonId : 944487
Antonino Gullo
  • Function : Author
  • PersonId : 944488
Giuseppe Mannanici
  • Function : Author
  • PersonId : 944491
Keith Marill
  • Function : Author
  • PersonId : 944492
Sybille Merceron
  • Function : Author
  • PersonId : 944493
John Poularas
  • Function : Author
  • PersonId : 944494
Giuseppe Ristagno
  • Function : Author
  • PersonId : 944495
Vicki Noble
  • Function : Author
  • PersonId : 944496
Sachita Shah
  • Function : Author
  • PersonId : 944497
Heidi Kimberly
  • Function : Author
  • PersonId : 944498
Riccardo Moretti
  • Function : Author
  • PersonId : 944500

Abstract

BACKGROUND: The purpose of the optic nerve sheath diameter (ONSD) research group project is to establish an individual patient-level database from high quality studies of ONSD ultrasonography for the detection of raised intracranial pressure (ICP), and to perform a systematic review and an individual patient data meta-analysis (IPDMA), which will provide a cutoff value to help physicians making decisions and encourage further research. Previous meta-analyses were able to assess the diagnostic accuracy of ONSD ultrasonography in detecting raised ICP but failed to determine a precise cutoff value. Thus, the ONSD research group was founded to synthesize data from several recent studies on the subject and to provide evidence on the diagnostic accuracy of ONSD ultrasonography in detecting raised ICP. METHODS: This IPDMA will be conducted in different phases. First, we will systematically search for eligible studies. To be eligible, studies must have compared ONSD ultrasonography to invasive intracranial devices, the current reference standard for diagnosing raised ICP. Subsequently, we will assess the quality of studies included based on the QUADAS-2 tool, and then collect and validate individual patient data. The objectives of the primary analyses will be to assess the diagnostic accuracy of ONSD ultrasonography and to determine a precise cutoff value for detecting raised ICP. Secondly, we will construct a logistic regression model to assess whether patient and study characteristics influence diagnostic accuracy. DISCUSSION: We believe that this IPD MA will provide the most reliable basis for the assessment of diagnostic accuracy of ONSD ultrasonography for detecting raised ICP and to provide a cutoff value. We also hope that the creation of the ONSD research group will encourage further study. TRIAL REGISTRATION: PROSPERO registration number: CRD42012003072.
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Dates and versions

inserm-00851700 , version 1 (16-08-2013)

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Julie Dubourg, Mahmoud Messerer, Dimitrios Karakitsos, Venkatakrishna Rajajee, Erik Antonsen, et al.. Individual patient data systematic review and meta-analysis of optic nerve sheath diameter ultrasonography for detecting raised intracranial pressure: protocol of the ONSD research group.. Systematic Reviews, 2013, 2 (1), pp.62. ⟨10.1186/2046-4053-2-62⟩. ⟨inserm-00851700⟩
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