T. Quinn, M. Wawer, N. Sewankambo, D. Serwadda, C. Li et al., Viral Load and Heterosexual Transmission of Human Immunodeficiency Virus Type 1, New England Journal of Medicine, vol.342, issue.13, pp.921-929, 2000.
DOI : 10.1056/NEJM200003303421303

P. Garcia, L. Kalish, J. Pitt, H. Minkoff, T. Quinn et al., Maternal Levels of Plasma Human Immunodeficiency Virus Type 1 RNA and the Risk of Perinatal Transmission, New England Journal of Medicine, vol.341, issue.6, pp.394-402, 1999.
DOI : 10.1056/NEJM199908053410602

F. Tanser, T. Bärnighausen, E. Grapsa, J. Zaidi, and M. Newell, High Coverage of ART Associated with Decline in Risk of HIV Acquisition in Rural KwaZulu-Natal, South Africa, Science, vol.339, issue.6122, pp.966-971, 2013.
DOI : 10.1126/science.1228160

R. Granich, C. Gilks, C. Dye, D. Cock, K. Williams et al., Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model, The Lancet, vol.373, issue.9657, pp.48-57, 2009.
DOI : 10.1016/S0140-6736(08)61697-9

P. Dodd, G. Garnett, and T. Hallett, Examining the promise of HIV elimination by ???test and treat??? in hyperendemic settings, AIDS, vol.24, issue.5, pp.729-735, 2010.
DOI : 10.1097/QAD.0b013e32833433fe

J. Eaton, L. Johnson, J. Salomon, T. Barnighausen, E. Bendavid et al., HIV Treatment as Prevention: Systematic Comparison of Mathematical Models of the Potential Impact of Antiretroviral Therapy on HIV Incidence in South Africa, PLoS Medicine, vol.21, issue.Suppl 2, p.1001245, 2012.
DOI : 10.1371/journal.pmed.1001245.t004

J. Hontelez, M. Lurie, T. Bärnighausen, R. Bakker, R. Baltussen et al., Treatment as prevention for HIV in South Africa: different models show consistency in occurrence, but difference in timing of elimination and the overall impact of the intervention, J Int AIDS Soc, vol.2012, p.15

M. Kitahata, S. Gange, A. Abraham, B. Merriman, M. Saag et al., Effect of Early versus Deferred Antiretroviral Therapy for HIV on Survival, New England Journal of Medicine, vol.360, issue.18, pp.1815-1826, 2009.
DOI : 10.1056/NEJMoa0807252

J. Sterne, M. May, D. Costagliola, D. Wolf, F. Phillips et al., Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies, Lancet, vol.373, pp.1352-1363, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00368642

X. Anglaret, A. Minga, D. Gabillard, T. Ouassa, E. Messou et al., AIDS and Non-AIDS Morbidity and Mortality Across the Spectrum of CD4 Cell Counts in HIV-Infected Adults Before Starting Antiretroviral Therapy in Cote d'Ivoire, Clinical Infectious Diseases, vol.54, issue.5, pp.714-723, 2012.
DOI : 10.1093/cid/cir898

T. Welz, V. Hosegood, S. Jaffar, J. Batzing-feigenbaum, K. Herbst et al., Continued very high prevalence of HIV infection in rural KwaZulu-Natal, South Africa: a population-based longitudinal study, AIDS, vol.21, issue.11, pp.1467-1472, 2007.
DOI : 10.1097/QAD.0b013e3280ef6af2

F. Tanser, T. Barnighausen, G. Cooke, and M. Newell, Localized spatial clustering of HIV infections in a widely disseminated rural South African epidemic, International Journal of Epidemiology, vol.38, issue.4, pp.1008-1016, 2009.
DOI : 10.1093/ije/dyp148

J. Zaidi, E. Grapsa, F. Tanser, M. Newell, and T. Bärnighausen, HIV prevalence trends after scale-up of antiretroviral treatment: a population-based study in a poor rural community in KwaZulu-Natal, J Int AIDS Soc, vol.2012, p.15

T. Barnighausen, F. Tanser, and M. Newell, Lack of a Decline in HIV Incidence in a Rural Community with High HIV Prevalence in South Africa, 2003???2007, AIDS Research and Human Retroviruses, vol.25, issue.4, pp.405-409, 2003.
DOI : 10.1089/aid.2008.0211

T. Barnighausen, C. Wallrauch, A. Welte, T. Mcwalter, N. Mbizana et al., HIV Incidence in Rural South Africa: Comparison of Estimates from Longitudinal Surveillance and Cross-Sectional cBED Assay Testing, PLoS ONE, vol.47, issue.11, p.3640, 2008.
DOI : 10.1371/journal.pone.0003640.t002

F. Tanser, T. Bärnighausen, and M. Newell, Identification of Localized Clusters of High HIV Incidence in a Widely Disseminated Rural South African Epidemic: A Case for Targeted Intervention Strategies, 18th Conference on Retroviruses and Opportunistic Infections (CROI), 2011.

H. Maheswaran, H. Thulare, D. Stanistreet, F. Tanser, and M. Newell, Starting a Home and Mobile HIV Testing Service in a Rural Area of South Africa, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.59, issue.3, pp.43-46, 2012.
DOI : 10.1097/QAI.0b013e3182414ed7

F. Tanser, V. Hosegood, T. Barnighausen, K. Herbst, M. Nyirenda et al., Cohort Profile: Africa Centre Demographic Information System (ACDIS) and population-based HIV survey, International Journal of Epidemiology, vol.37, issue.5, pp.956-962, 2008.
DOI : 10.1093/ije/dym211
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557060

F. Tanser, V. Hosegood, J. Benzler, and G. Solarsh, New approaches to spatially analyse primary health care usage patterns in rural South Africa, Tropical Medicine and International Health, vol.1, issue.10, pp.826-838, 2001.
DOI : 10.1097/00002030-199904160-00023

S. Goldie, Y. Yazdanpanah, E. Losina, M. Weinstein, X. Anglaret et al., Cost-Effectiveness of HIV Treatment in Resource-Poor Settings ??? The Case of C??te d'Ivoire, New England Journal of Medicine, vol.355, issue.11, pp.1141-1153, 2006.
DOI : 10.1056/NEJMsa060247

J. Hontelez, D. Vlas, S. Tanser, F. Bakker, R. Barnighausen et al., The Impact of the New WHO Antiretroviral Treatment Guidelines on HIV Epidemic Dynamics and Cost in South Africa, PLoS ONE, vol.3, issue.Suppl, p.21919, 2011.
DOI : 10.1371/journal.pone.0021919.s001

H. Grosskurth, F. Mosha, J. Todd, E. Mwijarubi, A. Klokke et al., Impact of improved treatment of sexually transmitted diseases on HIV infection in rural Tanzania: randomised controlled trial, The Lancet, vol.346, issue.8974, pp.530-536, 1995.
DOI : 10.1016/S0140-6736(95)91380-7

F. Tanser, T. Barnighausen, L. Hund, G. Garnett, N. Mcgrath et al., Effect of concurrent sexual partnerships on rate of new HIV infections in a high-prevalence, rural South African population: a cohort study, The Lancet, vol.378, issue.9787, pp.247-255, 2011.
DOI : 10.1016/S0140-6736(11)60779-4

K. Chaiyachati, L. Hirschhorn, F. Tanser, M. Newell, and T. Barnighausen, Validating Five Questions of Antiretroviral Nonadherence in a Public-Sector Treatment Program in Rural South Africa, AIDS Patient Care and STDs, vol.25, pp.163-170, 2010.
DOI : 10.1089/apc.2010.0257

S. Boyer, I. Clerc, C. Bonono, F. Marcellin, P. Bile et al., Non-adherence to antiretroviral treatment and unplanned treatment interruption among people living with HIV/AIDS in Cameroon: Individual and healthcare supply-related factors, Social Science & Medicine, vol.72, issue.8, pp.1383-1392, 2011.
DOI : 10.1016/j.socscimed.2011.02.030

P. Carrieri, V. Cailleton, L. Moing, V. Spire, B. Dellamonica et al., The Dynamic of Adherence to Highly Active Antiretroviral Therapy: Results From the French National APROCO Cohort, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.28, issue.3, pp.232-239, 2001.
DOI : 10.1097/00042560-200111010-00005

B. Spire, P. Carrieri, P. Sopha, C. Protopopescu, N. Prak et al., Adherence to antiretroviral therapy in patients enrolled in a comprehensive care program in Cambodia: a 24-month follow-up assessment, Antivir Ther, vol.13, pp.697-703, 2008.
URL : https://hal.archives-ouvertes.fr/inserm-00320461

M. Duracinsky, S. Herrmann, B. Berzins, A. Armstrong, R. Kohli et al., The Development of PROQOL-HIV, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.59, issue.5, pp.498-505, 2012.
DOI : 10.1097/QAI.0b013e318245cafe

M. Duracinsky, C. Lalanne, L. Coeur, S. Herrmann, S. Berzins et al., Psychometric Validation of the PROQOL-HIV Questionnaire, a New Health-Related Quality of Life Instrument???Specific to HIV Disease, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.59, issue.5, pp.506-515, 2012.
DOI : 10.1097/QAI.0b013e31824be3f2

W. Holzemer, L. Uys, M. Chirwa, M. Greeff, L. Makoae et al., Validation of the HIV/AIDS Stigma Instrument -PLWA (HASI-P). AIDS Care, pp.1002-1012, 2007.

O. Ukoumunne, J. Carlin, and M. Gulliford, A simulation study of odds ratio estimation for binary outcomes from cluster randomized trials, Statistics in Medicine, vol.55, issue.18, pp.3415-3428, 2007.
DOI : 10.1002/sim.2769

L. Mancl and T. Derouen, A Covariance Estimator for GEE with Improved Small-Sample Properties, Biometrics, vol.14, issue.1, pp.126-134, 2001.
DOI : 10.1111/j.0006-341X.2001.00126.x

S. Attia, M. Egger, M. Muller, M. Zwahlen, and N. Low, Sexual transmission of HIV according to viral load and antiretroviral therapy: systematic review and meta-analysis, AIDS, vol.23, issue.11, pp.1397-1404, 2009.
DOI : 10.1097/QAD.0b013e32832b7dca

A. Anglemyer, G. Rutherford, R. Baggaley, M. Egger, and N. Siegfried, Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples):CD009153. 42. World Health Organisation: Guidance on Couples HIV Testing and Counselling including Antiretroviral Therapy for Treatment and Prevention in Serodiscordant Couples. Recommendations for a public health approach World Health Organisation, Cochrane Database Syst Rev, issue.8, 2011.

B. Chi, R. Cantrell, I. Zulu, L. Mulenga, J. Levy et al., Adherence to first-line antiretroviral therapy affects non-virologic outcomes among patients on treatment for more than 12 months in Lusaka, Zambia, International Journal of Epidemiology, vol.38, issue.3, pp.746-756, 2009.
DOI : 10.1093/ije/dyp004

D. Maqutu, T. Zewotir, D. North, K. Naidoo, and A. Grobler, Factors affecting firstmonth adherence to antiretroviral therapy among HIV-positive adults in South Africa, Afr J AIDS Res, vol.2010, issue.92, pp.117-124

J. Uy, C. Armon, K. Buchacz, K. Wood, and J. Brooks, Initiation of HAART at Higher CD4 Cell Counts Is Associated With a Lower Frequency of Antiretroviral Drug Resistance Mutations at Virologic Failure, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.51, issue.4, pp.450-453, 2009.
DOI : 10.1097/QAI.0b013e3181acb630

T. Barnighausen, D. Bloom, and S. Humair, Economics of antiretroviral treatment vs. circumcision for HIV prevention, Proceedings of the National Academy of Sciences of the United States of America 2012, pp.21271-21276
DOI : 10.1073/pnas.1209017110

. Iwuji, Evaluation of the impact of immediate versus WHO recommendations-guided antiretroviral therapy initiation on HIV incidence: the ANRS 12249 TasP (Treatment as Prevention) trial in Hlabisa sub-district, KwaZulu-Natal, South Africa: study protocol for a cluster randomised controlled trial, Trials, vol.14, issue.1, p.230, 2013.
DOI : 10.1073/pnas.1209017110