Skip to Main content Skip to Navigation
Journal articles

Membrane microvesicles: a circulating source for fibrinolysis, new antithrombotic messengers.

Laurent Plawinski 1 Eduardo Anglés-Cano 2, * 
* Corresponding author
2 Inserm UMR_S765
U765 - Risque Thrombotique et Mecanismes de l'Hemostase
Abstract : Thrombus lysis is the consequence of a restricted number of reactions localised on the surface of fibrin and cell membranes. A functional defect or an insufficient fibrinolytic response may result in thrombosis with severe or fatal clinical consequences. Despite this clinical exigency and a real progress in the knowledge of the different components of this system (plasminogen activators, inhibitors and receptors) including structure-function relationship unveiled by the crystal structure of plasminogen, the functional evaluation of fibrinolysis still remains a challenge in haemostasis. Interestingly, we recently discovered that circulating membrane microvesicles might be indicators of the fibrinolytic response to an inflammatory or prothrombotic process via their participation in a new mechanism of plasmin formation requiring a cross-talk between two different surfaces. We propose that the fibrinolytic activity conveyed by microvesicles could be the real source of fibrinolysis in circulating blood.
Document type :
Journal articles
Complete list of metadata
Contributor : Eduardo Angles-Cano Connect in order to contact the contributor
Submitted on : Wednesday, August 14, 2013 - 12:28:56 PM
Last modification on : Monday, December 20, 2021 - 4:44:01 PM
Long-term archiving on: : Friday, November 15, 2013 - 9:28:17 AM


Publisher files allowed on an open archive



Laurent Plawinski, Eduardo Anglés-Cano. Membrane microvesicles: a circulating source for fibrinolysis, new antithrombotic messengers.. Haematologica, Ferrata Storti Foundation, 2013, 98 (7), pp.e75-6. ⟨10.3324/haematol.2013.088948⟩. ⟨inserm-00851463⟩



Record views


Files downloads