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Translation of the ecological trap concept to glioma therapy: the cancer cell trap concept.: The cancer cell trap concept

Boudewijn van der Sanden 1 Florence Appaix 2 François Berger 1 Laurent Selek 2 Jean-Paul Issartel 3 Didier Wion 3, *
* Corresponding author
1 INSERM U836, équipe 7, Nanomédecine et cerveau
GIN - Grenoble Institut des Neurosciences, Clinatec - Centre de recherche biomédicale Edmond J.Safra
3 Inserm U836, équipe 7, Nanomédecine et cerveau
GIN - Grenoble Institut des Neurosciences
Abstract : Viewing tumors as ecosystems offers the opportunity to consider how ecological concepts can be translated to novel therapeutic perspectives. The ecological trap concept emerged approximately half a century ago when it was observed that animals can prefer an environment of low quality for survival over other available environments of higher quality. The presence of such a trap can drive a local population to extinction. The cancer cell trap concept is the translation of the ecological trap into glioma therapy. It exploits and diverts the invasive potential of glioma cells by guiding their migration towards specific locations where a local therapy can be delivered efficiently. This illustrates how an ecological concept can change therapeutic obstacles into therapeutic tools.
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Boudewijn van der Sanden, Florence Appaix, François Berger, Laurent Selek, Jean-Paul Issartel, et al.. Translation of the ecological trap concept to glioma therapy: the cancer cell trap concept.: The cancer cell trap concept. Future Oncology, Future Medicine, 2013, 9 (6), pp.817-24. ⟨10.2217/fon.13.30⟩. ⟨inserm-00851156⟩

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