Translation of the ecological trap concept to glioma therapy: the cancer cell trap concept.

Boudewijn Van Der Sanden; Florence Appaix; François Berger; Laurent Selek; Jean-Paul Issartel; Didier Wion

doi:10.2217/fon.13.30

Translation of the ecological trap concept to glioma therapy: the cancer cell trap concept.: The cancer cell trap concept

Boudewijn Van Der Sanden ¹ Florence Appaix ² François Berger ¹ Laurent Selek ² Jean-Paul Issartel ³ Didier Wion ^{3, *}

* Auteur correspondant

1 INSERM U836, équipe 7, Nanomédecine et cerveau

GIN - Grenoble Institut des Neurosciences, Clinatec - Centre de recherche biomédicale Edmond J.Safra

2 GIN - Grenoble Institut des Neurosciences

3 Inserm U836, équipe 7, Nanomédecine et cerveau

GIN - Grenoble Institut des Neurosciences

Abstract : Viewing tumors as ecosystems offers the opportunity to consider how ecological concepts can be translated to novel therapeutic perspectives. The ecological trap concept emerged approximately half a century ago when it was observed that animals can prefer an environment of low quality for survival over other available environments of higher quality. The presence of such a trap can drive a local population to extinction. The cancer cell trap concept is the translation of the ecological trap into glioma therapy. It exploits and diverts the invasive potential of glioma cells by guiding their migration towards specific locations where a local therapy can be delivered efficiently. This illustrates how an ecological concept can change therapeutic obstacles into therapeutic tools.

keyword : Ecological trap glioma cancer therapy

Type de document :

Article dans une revue

Future Oncology, Future Medicine, 2013, 9 (6), pp.817-24. 〈10.2217/fon.13.30〉

Domaine :

Sciences du Vivant [q-bio] / Cancer

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http://www.hal.inserm.fr/inserm-00851156
Contributeur : Jean-Paul Issartel <>
Soumis le : mercredi 4 juin 2014 - 14:46:02
Dernière modification le : dimanche 4 février 2018 - 19:02:05
Document(s) archivé(s) le : jeudi 4 septembre 2014 - 10:38:02

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