N. Ruperto, H. Brunner, P. Quartier, T. Constantin, N. Wulffraat et al., Two Randomized Trials of Canakinumab in Systemic Juvenile Idiopathic Arthritis, New England Journal of Medicine, vol.367, issue.25, pp.2396-2406, 2012.
DOI : 10.1056/NEJMoa1205099

P. Quartier, F. Allantaz, R. Cimaz, P. Pillet, C. Messiaen et al., A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial), Annals of the Rheumatic Diseases, vol.70, issue.5, pp.747-754, 2011.
DOI : 10.1136/ard.2010.134254

T. Lequerré, P. Quartier, D. Rosellini, F. Alaoui, D. Bandt et al., Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in France, Annals of the Rheumatic Diseases, vol.67, issue.3, pp.302-308, 2008.
DOI : 10.1136/ard.2007.076034

V. Pascual, F. Allantaz, E. Arce, M. Punaro, and J. Banchereau, Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade, The Journal of Experimental Medicine, vol.31, issue.9, pp.1479-1486, 2005.
DOI : 10.1002/art.1780290216

B. Neven, I. Marvillet, C. Terrada, A. Ferster, N. Boddaert et al., Long-term efficacy of the interleukin-1 receptor antagonist anakinra in ten patients with neonatal-onset multisystem inflammatory disease/chronic infantile neurologic, cutaneous, articular syndrome, Arthritis & Rheumatism, vol.58, issue.1, pp.258-267, 2010.
DOI : 10.1002/art.25057

M. Lavielle and F. Mentré, Estimation of Population Pharmacokinetic Parameters of Saquinavir in HIV Patients with the MONOLIX Software, Journal of Pharmacokinetics and Pharmacodynamics, vol.32, issue.2, pp.229-249, 2007.
DOI : 10.1007/s10928-006-9043-z
URL : https://hal.archives-ouvertes.fr/inserm-00156907

E. Comets, K. Brendel, and F. Mentré, Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: The npde add-on package for R, Computer Methods and Programs in Biomedicine, vol.90, issue.2, pp.154-166, 2008.
DOI : 10.1016/j.cmpb.2007.12.002
URL : https://hal.archives-ouvertes.fr/inserm-00274332

R. Ihaka and R. Gentleman, R: A Language for Data Analysis and Graphics, Journal of Computational and Graphical Statistics, vol.5, pp.299-314, 1996.

B. Anderson and N. Holford, Mechanism-Based Concepts of Size and Maturity in Pharmacokinetics, Annual Review of Pharmacology and Toxicology, vol.48, issue.1, pp.303-332, 2008.
DOI : 10.1146/annurev.pharmtox.48.113006.094708