V. Agnello, G. Abel, M. Elfahal, G. Knight, and Q. Zhang, Hepatitis C virus and other Flaviviridae viruses enter cells via low density lipoprotein receptor, Proceedings of the National Academy of Sciences, vol.96, issue.22, pp.12766-12771, 1999.
DOI : 10.1073/pnas.96.22.12766

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC23090

H. Aizaki, K. Morikawa, M. Fukasawa, H. Hara, Y. Inoue et al., Critical Role of Virion-Associated Cholesterol and Sphingolipid in Hepatitis C Virus Infection, Journal of Virology, vol.82, issue.12, pp.5715-5724, 2008.
DOI : 10.1128/JVI.02530-07

A. Albecka, S. Belouzard, A. De-beeck, V. Descamps, L. Goueslain et al., Role of low-density lipoprotein receptor in the hepatitis C virus life cycle, Hepatology, vol.141, issue.Suppl 1, pp.998-1007, 2012.
DOI : 10.1002/hep.25501

S. Altmann, H. Davis, J. Yao, X. Laverty, M. Compton et al., The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol.1580, issue.1, pp.77-93, 2002.
DOI : 10.1016/S1388-1981(01)00190-1

P. Andre, F. Komurian-pradel, S. Deforges, M. Perret, J. Berland et al., Characterization of Low- and Very-Low-Density Hepatitis C Virus RNA-Containing Particles, Journal of Virology, vol.76, issue.14, pp.6919-6928, 2002.
DOI : 10.1128/JVI.76.14.6919-6928.2002

U. Andreo, P. Maillard, O. Kalinina, M. Walic, E. Meurs et al., Lipoprotein lipase mediates hepatitis C virus (HCV) cell entry and inhibits HCV infection, Cellular Microbiology, vol.267, issue.10, pp.2445-2456, 2007.
DOI : 10.1128/JVI.01307-06

R. Bartenschlager, Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly, PLoS pathogens, vol.4, p.1000035, 2008.

D. Bankwitz, E. Steinmann, J. Bitzegeio, S. Ciesek, M. Friesland et al., Hepatitis C Virus Hypervariable Region 1 Modulates Receptor Interactions, Conceals the CD81 Binding Site, and Protects Conserved Neutralizing Epitopes, Journal of Virology, vol.84, issue.11, pp.5751-5763, 2010.
DOI : 10.1128/JVI.02200-09

V. Ghisetti, B. Lavezzo, H. Blum, F. Von-weizsacker, A. Vitelli et al., Scavenger receptor class B type I and hepatitis C virus infection of primary tupaia hepatocytes, J Virol, vol.79, pp.5774-5785, 2005.

H. Barth, T. Liang, and T. Baumert, Hepatitis C virus entry: Molecular biology and clinical implications, Hepatology, vol.7, issue.3, pp.527-535, 2006.
DOI : 10.1002/hep.21321

H. Barth, C. Schäfer, M. Adah, F. Zhang, R. Linhardt et al., Cellular Binding of Hepatitis C Virus Envelope Glycoprotein E2 Requires Cell Surface Heparan Sulfate, Journal of Biological Chemistry, vol.278, issue.42, 2003.
DOI : 10.1074/jbc.M302267200

H. Barth, E. Schnober, C. Neumann-haefelin, C. Thumann, M. Zeisel et al., Scavenger Receptor Class B Is Required for Hepatitis C Virus Uptake and Cross-Presentation by Human Dendritic Cells, Journal of Virology, vol.82, issue.7, pp.3466-3479, 2008.
DOI : 10.1128/JVI.02478-07

H. Barth, E. Schnober, F. Zhang, R. Linhardt, E. Depla et al., Viral and Cellular Determinants of the Hepatitis C Virus Envelope-Heparan Sulfate Interaction, Journal of Virology, vol.80, issue.21, pp.10579-10590, 2006.
DOI : 10.1128/JVI.00941-06

R. Thimme, P. Henneke, R. Klein, G. Paranhos-baccala, E. Depla et al., Uptake and presentation of hepatitis C virus-like particles by human dendritic cells, Blood, vol.105, pp.3605-3614, 2005.

B. Bartosch and F. Cosset, Cell entry of hepatitis C virus, Virology, vol.348, issue.1, pp.1-12, 2006.
DOI : 10.1016/j.virol.2005.12.027

URL : https://hal.archives-ouvertes.fr/hal-00105453

B. Bartosch, J. Dubuisson, and F. Cosset, Infectious Hepatitis C Virus Pseudo-particles Containing Functional E1???E2 Envelope Protein Complexes, The Journal of Experimental Medicine, vol.72, issue.5, pp.633-642, 2003.
DOI : 10.1093/emboj/21.12.2893

URL : https://hal.archives-ouvertes.fr/inserm-00133783

B. Bartosch, G. Verney, M. Dreux, P. Donot, Y. Morice et al., An interplay between hypervariable region 1 of the hepatitis C virus E2 glycoprotein, the scavenger receptor BI, and high-density lipoprotein promotes both 24, 2005.

B. Bartosch, A. Vitelli, C. Granier, C. Goujon, J. Dubuisson et al., Cell Entry of Hepatitis C Virus Requires a Set of Co-receptors That Include the CD81 Tetraspanin and the SR-B1 Scavenger Receptor, Journal of Biological Chemistry, vol.278, issue.43, pp.41624-41630, 2003.
DOI : 10.1074/jbc.M305289200

T. Baumert, S. Ito, D. Wong, and T. Liang, Hepatitis C virus structural proteins assemble into viruslike particles in insect cells, J. Virol, vol.72, pp.3827-3836, 1998.

I. Benedicto, F. Molina-jimenez, O. Barreiro, A. Maldonado-rodriguez, J. Prieto et al., Hepatitis C virus envelope components alter localization of hepatocyte tight junction-associated proteins and promote occludin retention in the endoplasmic reticulum, Hepatology, vol.82, issue.7-8, pp.1044-1053, 2008.
DOI : 10.1002/hep.22465

I. Benedicto, F. Molina-jimenez, B. Bartosch, F. Cosset, D. Lavillette et al., The Tight Junction-Associated Protein Occludin Is Required for a Postbinding Step in Hepatitis C Virus Entry and Infection, Journal of Virology, vol.83, issue.16, pp.8012-8020, 2009.
DOI : 10.1128/JVI.00038-09

J. Mclauchlan, T. Baumert, and C. Schuster, Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles, Hepatology, vol.51, pp.43-53, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00705655

K. Berneis and R. Krauss, Metabolic origins and clinical significance of LDL heterogeneity, The Journal of Lipid Research, vol.43, issue.9, pp.1363-1379, 2002.
DOI : 10.1194/jlr.R200004-JLR200

C. Bertaux and T. Dragic, Different Domains of CD81 Mediate Distinct Stages of Hepatitis C Virus Pseudoparticle Entry, Journal of Virology, vol.80, issue.10, pp.4940-4948, 2006.
DOI : 10.1128/JVI.80.10.4940-4948.2006

E. Blanchard, S. Belouzard, L. Goueslain, T. Wakita, J. Dubuisson et al., Hepatitis C Virus Entry Depends on Clathrin-Mediated Endocytosis, Journal of Virology, vol.80, issue.14, pp.6964-6972, 2006.
DOI : 10.1128/JVI.00024-06

URL : https://hal.archives-ouvertes.fr/hal-00105504

E. Blanchard, D. Brand, S. Trassard, A. Goudeau, and P. Roingeard, Hepatitis C Virus-Like Particle Morphogenesis, Journal of Virology, vol.76, issue.8, pp.4073-4079, 2002.
DOI : 10.1128/JVI.76.8.4073-4079.2002

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136094

Y. Boriskin, I. Leneva, E. Pecheur, and S. Polyak, Arbidol: A Broad-Spectrum Antiviral Compound that Blocks Viral Fusion, Current Medicinal Chemistry, vol.15, issue.10, pp.997-1005, 2008.
DOI : 10.2174/092986708784049658

Y. Boriskin, E. Pecheur, and S. Polyak, Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection, Virology Journal, vol.3, issue.1, p.56, 2006.
DOI : 10.1186/1743-422X-3-56

S. Boulant, P. Targett-adams, and J. Mclauchlan, Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus, Journal of General Virology, vol.88, issue.8, pp.2204-2213, 2007.
DOI : 10.1099/vir.0.82898-0

S. Bridge, D. Sheridan, D. Felmlee, S. Nielsen, H. Thomas et al., Insulin resistance and low-density apolipoprotein B-associated lipoviral particles in hepatitis C virus genotype 1 infection, Gut, vol.60, issue.5, pp.680-687, 2011.
DOI : 10.1136/gut.2010.222133

C. Brimacombe, J. Grove, L. Meredith, K. Hu, A. Syder et al., Neutralizing Antibody-Resistant Hepatitis C Virus Cell-to-Cell Transmission, Journal of Virology, vol.85, issue.1, pp.596-605, 2011.
DOI : 10.1128/JVI.01592-10

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014195

J. Bukh, Animal Models for the Study of Hepatitis C Virus Infection and Related Liver Disease, Gastroenterology, vol.142, issue.6, pp.1279-1287, 2012.
DOI : 10.1053/j.gastro.2012.02.016

R. Cortese, A. Vitelli, and A. Nicosia, Role of scavenger receptor class B type I in hepatitis C virus entry: kinetics and molecular determinants, J Virol, vol.84, pp.34-43, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00580589

M. Catanese, R. Graziani, T. Von-hahn, M. Moreau, T. Huby et al., High-Avidity Monoclonal Antibodies against the Human Scavenger Class B Type I Receptor Efficiently Block Hepatitis C Virus Infection in the Presence of High-Density Lipoprotein, Journal of Virology, vol.81, issue.15, pp.8063-8071, 2007.
DOI : 10.1128/JVI.00193-07

K. Chang, J. Jiang, Z. Cai, and G. Luo, Human Apolipoprotein E Is Required for Infectivity and Production of Hepatitis C Virus in Cell Culture, Journal of Virology, vol.81, issue.24, pp.13783-13793, 2007.
DOI : 10.1128/JVI.01091-07

S. Chevaliez and T. Asselah, Mechanisms of non-response to antiviral treatment in chronic hepatitis C. Clinics and research in hepatology and gastroenterology 35, pp.31-41, 2011.

Q. Choo, A. Kuo, A. Weiner, L. Overby, D. Bradley et al., Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome, Science, vol.244, issue.4902, pp.359-362, 1989.
DOI : 10.1126/science.2523562

A. Codran, C. Royer, D. Jaeck, M. Bastien-valle, T. Baumert et al., Entry of hepatitis C virus pseudotypes into primary human hepatocytes by clathrin-dependent endocytosis, Journal of General Virology, vol.87, issue.9, pp.2583-2593, 2006.
DOI : 10.1099/vir.0.81710-0

K. Coller, K. Berger, N. Heaton, J. Cooper, R. Yoon et al., RNA Interference and Single Particle Tracking Analysis of Hepatitis C Virus Endocytosis, PLoS Pathogens, vol.48, issue.12, p.1000702, 2009.
DOI : 10.1371/journal.ppat.1000702.s009

E. Cormier, R. Durso, F. Tsamis, L. Boussemart, C. Manix et al., L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus, Proceedings of the National Academy of Sciences, vol.101, issue.39, pp.14067-14072, 2004.
DOI : 10.1073/pnas.0405695101

L. Cukierman, L. Meertens, C. Bertaux, F. Kajumo, and T. Dragic, Residues in a Highly Conserved Claudin-1 Motif Are Required for Hepatitis C Virus Entry and Mediate the Formation of Cell-Cell Contacts, Journal of Virology, vol.83, issue.11, pp.5477-5484, 2009.
DOI : 10.1128/JVI.02262-08

W. Cun, J. Jiang, and G. Luo, The C-Terminal ??-Helix Domain of Apolipoprotein E Is Required for Interaction with Nonstructural Protein 5A and Assembly of Hepatitis C Virus, Journal of Virology, vol.84, issue.21, pp.11532-11541, 2010.
DOI : 10.1128/JVI.01021-10

D. Thi, V. Granier, C. Zeisel, M. Guerin, M. Mancip et al., Characterization of Hepatitis C Virus Particle Subpopulations Reveals Multiple Usage of the Scavenger Receptor BI for Entry Steps, J Biol Chem, vol.287, pp.31242-31257, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00965024

Y. Li, R. Whitley, J. Gnann, and J. , A randomized, open-label study to evaluate the 27, 2005.

M. Catanese, D. Burton, M. Law, C. Rice, and A. Ploss, A genetically humanized mouse model for hepatitis C virus infection, Nature, vol.474, pp.208-211, 2011.

M. Dreux, B. Boson, R. -. Blum, S. Molle, J. Lavillette et al., The Exchangeable Apolipoprotein ApoC-I Promotes Membrane Fusion of Hepatitis C Virus, Journal of Biological Chemistry, vol.282, issue.44, pp.32357-32369, 2007.
DOI : 10.1074/jbc.M705358200

URL : https://hal.archives-ouvertes.fr/hal-00315131

D. Lavillette, F. Cosset, and B. Bartosch, Receptor complementation and mutagenesis reveal SR-BI as an essential HCV entry factor and functionally imply its intra-and extracellular domains, PLoS pathogens, vol.5, p.1000310, 2009.

M. Dreux, T. Pietschmann, C. Granier, C. Voisset, R. -. Blum et al., High Density Lipoprotein Inhibits Hepatitis C Virus-neutralizing Antibodies by Stimulating Cell Entry via Activation of the Scavenger Receptor BI, Journal of Biological Chemistry, vol.281, issue.27, pp.18285-18295, 2006.
DOI : 10.1074/jbc.M602706200

URL : https://hal.archives-ouvertes.fr/inserm-00133952

H. Drummer, I. Boo, and P. Poumbourios, Mutagenesis of a conserved fusion peptide-like motif and membrane-proximal heptad-repeat region of hepatitis C virus glycoprotein E1, Journal of General Virology, vol.88, issue.4, 2007.
DOI : 10.1099/vir.0.82567-0

J. Mckeating, P. Bieniasz, and C. Rice, Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry, Nature, vol.446, pp.801-805, 2007.

S. Fafi-kremer, I. Fofana, E. Soulier, P. Carolla, P. Meuleman et al., Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation, The Journal of Experimental Medicine, vol.119, issue.9, pp.2019-2031, 2010.
DOI : 10.1073/pnas.0503596102

M. Farquhar, K. Hu, H. Harris, C. Davis, C. Brimacombe et al., Hepatitis C Virus Induces CD81 and Claudin-1 Endocytosis, Journal of Virology, vol.86, issue.8, pp.4305-4316, 2012.
DOI : 10.1128/JVI.06996-11

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318669

J. Mclauchlan, G. Toms, R. Neely, and M. Bassendine, Intravascular transfer contributes to postprandial increase in numbers of very-low-density hepatitis C virus particles, 2010.

S. Levy and J. Mckeating, Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor CD81, J. Virol, vol.73, pp.6235-6244, 1999.

J. Hayer, C. Combet, F. Cosset, T. Pietschmann, M. Hiet et al., Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies, Gastroenterology, vol.143, pp.223-233, 2012.
URL : https://hal.archives-ouvertes.fr/inserm-00701511

J. Thompson and T. Baumert, Monoclonal anti-claudin 1 antibodies prevent hepatitis C virus infection of primary human hepatocytes, Gastroenterology, vol.39, pp.953-964, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00741442

S. Frey, M. Houghton, S. Coates, S. Abrignani, D. Chien et al., Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults, Vaccine, vol.28, issue.38, pp.6367-6373, 2010.
DOI : 10.1016/j.vaccine.2010.06.084

P. Garrone, A. Fluckiger, P. Mangeot, E. Gauthier, P. Dupeyrot-lacas et al., A Prime-Boost Strategy Using Virus-Like Particles Pseudotyped for HCV Proteins Triggers Broadly Neutralizing Antibodies in Macaques, Science Translational Medicine, vol.3, issue.94, pp.94-71, 2011.
DOI : 10.1126/scitranslmed.3002330

P. Gastaminza, G. Cheng, S. Wieland, J. Zhong, W. Liao et al., Cellular Determinants of Hepatitis C Virus Assembly, Maturation, Degradation, and Secretion, Journal of Virology, vol.82, issue.5, pp.2120-2129, 2008.
DOI : 10.1128/JVI.02053-07

P. Gastaminza, S. Kapadia, and F. Chisari, Differential Biophysical Properties of Infectious Intracellular and Secreted Hepatitis C Virus Particles, Journal of Virology, vol.80, issue.22, pp.11074-11081, 2006.
DOI : 10.1128/JVI.01150-06

E. Giang, M. Dorner, J. Prentoe, M. Dreux, M. Evans et al., Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus, Proceedings of the National Academy of Sciences, vol.109, issue.16, pp.6205-6210, 2012.
DOI : 10.1073/pnas.1114927109

M. Moreau, J. Owen, G. Leroux-roels, P. Balfe, and J. Mckeating, Scavenger receptor BI and BII expression levels modulate Hepatitis C virus infectivity, J Virol, vol.81, pp.3162-3169, 2007.

J. Grove, S. Nielsen, J. Zhong, M. Bassendine, H. Drummer et al., Identification of a Residue in Hepatitis C Virus E2 Glycoprotein That Determines Scavenger Receptor BI and CD81 Receptor Dependency and Sensitivity to Neutralizing Antibodies, Journal of Virology, vol.82, issue.24, pp.12020-12029, 2008.
DOI : 10.1128/JVI.01569-08

A. Haberstroh, E. Schnober, M. Zeisel, P. Carolla, H. Barth et al., Neutralizing Host Responses in Hepatitis C Virus Infection Target Viral Entry at Postbinding Steps and Membrane Fusion, Gastroenterology, vol.135, issue.5, 2008.
DOI : 10.1053/j.gastro.2008.07.018

S. Haid, T. Pietschmann, and E. Pecheur, Low pH-dependent Hepatitis C Virus Membrane Fusion Depends on E2 Integrity, Target Lipid Composition, and Density of Virus Particles, Journal of Biological Chemistry, vol.284, issue.26, pp.17657-17667, 2009.
DOI : 10.1074/jbc.M109.014647

J. Halliday, P. Klenerman, and E. Barnes, Vaccination for hepatitis C virus: closing in on an evasive target, Expert Review of Vaccines, vol.10, issue.5, pp.659-672, 2011.
DOI : 10.1586/erv.11.55

H. Harris, C. Davis, J. Mullins, K. Hu, M. Goodall et al., Claudin Association with CD81 Defines Hepatitis C Virus Entry, Journal of Biological Chemistry, vol.285, issue.27, pp.21092-21102, 2010.
DOI : 10.1074/jbc.M110.104836

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898367

H. Harris, M. Farquhar, C. Mee, C. Davis, G. Reynolds et al., CD81 and Claudin 1 Coreceptor Association: Role in Hepatitis C Virus Entry, Journal of Virology, vol.82, issue.10, pp.5007-5020, 2008.
DOI : 10.1128/JVI.02286-07

N. Afdhal, V. Navarro, J. Berman, Q. Liu, E. Doo et al., Silymarin ascending multiple oral dosing phase I study in noncirrhotic patients with chronic hepatitis C, Journal of clinical pharmacology, vol.50, pp.434-449, 2010.

M. Hijikata, Y. Shimizu, H. Kato, A. Iwamoto, J. Shih et al., Equilibrium centrifugation studies of hepatitis C virus: evidence for circulating immune complexes, J Virol, vol.67, pp.1953-1958, 1993.

T. Hishiki, Y. Shimizu, R. Tobita, K. Sugiyama, K. Ogawa et al., Infectivity of Hepatitis C Virus Is Influenced by Association with Apolipoprotein E Isoforms, Journal of Virology, vol.84, issue.22, pp.12048-12057, 2010.
DOI : 10.1128/JVI.01063-10

M. Houghton, Prospects for prophylactic and therapeutic vaccines against the hepatitis C viruses, Immunological Reviews, vol.436, issue.Suppl., pp.99-108, 2012.
DOI : 10.1111/j.1600-065X.2010.00977.x

H. Huang, F. Sun, D. Owen, W. Li, Y. Chen et al., Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins, Proceedings of the National Academy of Sciences, vol.104, issue.14, pp.5848-5853, 2007.
DOI : 10.1073/pnas.0700760104

D. Gordon, Evidence that microsomal triglyceride transfer protein is limiting in the production of apolipoprotein B-containing lipoproteins in hepatic cells, Journal of lipid research, vol.39, pp.1448-1454, 1998.

L. Jia, J. Betters, and L. Yu, Niemann-Pick C1-Like 1 (NPC1L1) Protein in Intestinal and Hepatic Cholesterol Transport, Annual Review of Physiology, vol.73, issue.1, pp.239-259, 2011.
DOI : 10.1146/annurev-physiol-012110-142233

J. Jiang, W. Cun, X. Wu, Q. Shi, H. Tang et al., Hepatitis C Virus Attachment Mediated by Apolipoprotein E Binding to Cell Surface Heparan Sulfate, Journal of Virology, vol.86, issue.13, 2012.
DOI : 10.1128/JVI.07222-11

J. Jiang and G. Luo, Apolipoprotein E but Not B Is Required for the Formation of Infectious Hepatitis C Virus Particles, Journal of Virology, vol.83, issue.24, pp.12680-12691, 2009.
DOI : 10.1128/JVI.01476-09

C. Jones, M. Catanese, L. Law, S. Khetani, A. Syder et al., Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system, Nature Biotechnology, vol.101, issue.2, pp.167-171, 2010.
DOI : 10.1038/nbt.1604

T. Kamada, Density analysis of hepatitis C virus particle population in the circulation of infected hosts: implications for virus neutralization or persistence, Journal of hepatology, vol.22, pp.440-448, 1995.

S. Kapadia, H. Barth, T. Baumert, J. Mckeating, and F. Chisari, Initiation of Hepatitis C Virus Infection Is Dependent on Cholesterol and Cooperativity between CD81 and Scavenger Receptor B Type I, Journal of Virology, vol.81, issue.1, pp.374-383, 2007.
DOI : 10.1128/JVI.01134-06

M. Kobayashi, M. Bennett, T. Bercot, and I. Singh, Functional Analysis of Hepatitis C Virus Envelope Proteins, Using a Cell-Cell Fusion Assay, Journal of Virology, vol.80, issue.4, pp.1817-1825, 2006.
DOI : 10.1128/JVI.80.4.1817-1825.2006

G. Koutsoudakis, A. Kaul, E. Steinmann, S. Kallis, V. Lohmann et al., Characterization of the Early Steps of Hepatitis C Virus Infection by Using Luciferase Reporter Viruses, Journal of Virology, vol.80, issue.11, pp.5308-5320, 2006.
DOI : 10.1128/JVI.02460-05

C. Royer, M. Lambotin, F. Grunert, D. Thi, V. Dreux et al., Inhibition of hepatitis C virus infection by anti-claudin-1 antibodies is mediated by neutralization of E2-CD81-claudin-1 associations, Hepatology, vol.51, pp.1144-1157, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00705657

K. Lacek, K. Vercauteren, K. Grzyb, M. Naddeo, L. Verhoye et al., Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice, Journal of Hepatology, vol.57, issue.1, pp.17-23, 2012.
DOI : 10.1016/j.jhep.2012.02.018

M. Lavie, A. Goffard, and J. Dubuisson, Assembly of a functional HCV glycoprotein heterodimer, Current issues in molecular biology, vol.9, pp.71-86, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00183316

D. Lavillette, B. Bartosch, D. Nourrisson, G. Verney, F. Cosset et al., Hepatitis C Virus Glycoproteins Mediate Low pH-dependent Membrane Fusion with Liposomes, Journal of Biological Chemistry, vol.281, issue.7, 2006.
DOI : 10.1074/jbc.M509747200

URL : https://hal.archives-ouvertes.fr/hal-00313675

D. Lavillette, E. Pecheur, P. Donot, J. Fresquet, J. Molle et al., Characterization of Fusion Determinants Points to the Involvement of Three Discrete Regions of Both E1 and E2 Glycoproteins in the Membrane Fusion Process of Hepatitis C Virus, Journal of Virology, vol.81, issue.16, 2007.
DOI : 10.1128/JVI.02642-06

M. Law, T. Maruyama, J. Lewis, E. Giang, A. Tarr et al., Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge, Nature Medicine, vol.78, issue.1, pp.25-27, 2008.
DOI : 10.1016/j.virol.2006.05.015

B. Lindenbach, P. Meuleman, A. Ploss, T. Vanwolleghem, A. Syder et al., Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro, Proceedings of the National Academy of Sciences, vol.103, issue.10, pp.3805-3809, 2006.
DOI : 10.1073/pnas.0511218103

B. Lindenbach, H. Thiel, and C. Rice, Flaviviridae: the viruses and their replication, pp.1101-1152, 2007.

S. Liu, K. Mccormick, W. Zhao, T. Zhao, D. Fan et al., Human apolipoprotein E peptides inhibit hepatitis C virus entry by blocking virus binding, Hepatology, vol.141, issue.2, 2012.
DOI : 10.1002/hep.25665

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362681

S. Liu, Y. W. Shen, L. Turner, J. Coyne, C. Wang et al., Tight Junction Proteins Claudin-1 and Occludin Control Hepatitis C Virus Entry and Are Downregulated during Infection To Prevent Superinfection, Journal of Virology, vol.83, issue.4, pp.2011-2014, 2009.
DOI : 10.1128/JVI.01888-08

P. Lozach, A. A. Bartosch, B. Virelizier, J. Arenzana-seisdedos, F. Cosset et al., C-type Lectins L-SIGN and DC-SIGN Capture and Transmit Infectious Hepatitis C Virus Pseudotype Particles, Journal of Biological Chemistry, vol.279, issue.31, pp.32035-32045, 2004.
DOI : 10.1074/jbc.M402296200

I. Ludwig, A. Lekkerkerker, E. Depla, F. Bosman, R. Musters et al., Hepatitis C Virus Targets DC-SIGN and L-SIGN To Escape Lysosomal Degradation, Journal of Virology, vol.78, issue.15, pp.8322-8332, 2004.
DOI : 10.1128/JVI.78.15.8322-8332.2004

S. Gorke, C. Royer, B. Fischer, M. Zahid, D. Lavillette et al., EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy, Nature medicine, vol.17, pp.589-595, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-00705829

P. Maillard, T. Huby, U. Andreo, M. Moreau, J. Chapman et al., The interaction of natural hepatitis C virus with human scavenger receptor SR-BI/Cla1 is mediated by ApoBcontaining lipoproteins, Faseb J, vol.20, pp.735-737, 2006.

E. Pecheur and A. Budkowska, Lipoprotein lipase inhibits hepatitis C virus (HCV) infection by blocking virus cell entry, PLoS ONE, vol.6, pp.26637-26671, 2011.

T. Matsumura, Z. Hu, T. Kato, M. Dreux, Y. Zhang et al., Amphipathic DNA Polymers Inhibit Hepatitis C Virus Infection by Blocking Viral Entry, Gastroenterology, vol.137, issue.2, pp.673-681, 2009.
DOI : 10.1053/j.gastro.2009.04.048

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803092

B. Mazumdar, A. Banerjee, K. Meyer, and R. Ray, Hepatitis C virus E1 envelope glycoprotein interacts with apolipoproteins in facilitating entry into hepatocytes, Hepatology, vol.136, issue.4, pp.1149-1156, 2011.
DOI : 10.1002/hep.24523

J. Mckeating, Polarization restricts hepatitis C virus entry into HepG2 hepatoma cells, 2009.

L. Meertens, C. Bertaux, and T. Dragic, Hepatitis C Virus Entry Requires a Critical Postinternalization Step and Delivery to Early Endosomes via Clathrin-Coated Vesicles, Journal of Virology, vol.80, issue.23, pp.11571-11578, 2006.
DOI : 10.1128/JVI.01717-06

L. Mensa, G. Crespo, M. Gastinger, J. Kabat, S. Perez-del-pulgar et al., Hepatitis C virus receptors claudin-1 and occludin after liver transplantation and influence on early viral kinetics, Hepatology, vol.47, issue.5, pp.1436-1445, 2011.
DOI : 10.1002/hep.24110

A. Merz, G. Long, M. Hiet, B. Brugger, P. Chlanda et al., Biochemical and Morphological Properties of Hepatitis C Virus Particles and Determination of Their Lipidome, Journal of Biological Chemistry, vol.286, issue.4, pp.3018-3032, 2011.
DOI : 10.1074/jbc.M110.175018

G. Roels, K. Palmer, and J. Dubuisson, Griffithsin has antiviral activity against hepatitis C virus, Antimicrob Agents Chemother, vol.55, pp.5159-5167, 2011.

H. Alter, R. Purcell, and G. Leroux-roels, In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus, Hepatology, vol.53, pp.755-762, 2011.

P. Meuleman, M. Catanese, L. Verhoye, I. Desombere, A. Farhoudi et al., A Human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo, Hepatology, vol.17, issue.2, pp.364-372, 2012.
DOI : 10.1002/hep.24692

G. Roels, Anti-CD81 antibodies can prevent a hepatitis C virus infection in vivo, 2008.

H. Miyamoto, H. Okamoto, K. Sato, T. Tanaka, and S. Mishiro, Extraordinarily low density of hepatitis C virus estimated by sucrose density gradient centrifugation and the polymerase chain reaction, Journal of General Virology, vol.73, issue.3, pp.715-718, 1992.
DOI : 10.1099/0022-1317-73-3-715

Y. Miyanari, K. Atsuzawa, N. Usuda, K. Watashi, T. Hishiki et al., The lipid droplet is an important organelle for hepatitis C virus production, Nature Cell Biology, vol.71, issue.9, pp.1089-1097, 2007.
DOI : 10.1007/s00418-005-0061-5

M. Monazahian, I. Bohme, S. Bonk, A. Koch, C. Scholz et al., Low density lipoprotein receptor as a candidate receptor for hepatitis C virus, Journal of Medical Virology, vol.208, issue.3, pp.223-229, 1999.
DOI : 10.1002/(SICI)1096-9071(199903)57:3<223::AID-JMV2>3.0.CO;2-4

K. Morikawa, Z. Zhao, T. Date, M. Miyamoto, A. Murayama et al., The roles of CD81 and glycosaminoglycans in the adsorption and uptake of infectious HCV particles, Journal of Medical Virology, vol.102, issue.6, pp.714-723, 2007.
DOI : 10.1002/jmv.20842

C. Murray and C. Rice, Turning Hepatitis C into a Real Virus, Annual Review of Microbiology, vol.65, issue.1, pp.307-327, 2011.
DOI : 10.1146/annurev-micro-090110-102954

U. Neumann, M. Biermer, D. Eurich, P. Neuhaus, and T. Berg, Successful prevention of hepatitis C virus (HCV) liver graft reinfection by silibinin mono-therapy, Journal of Hepatology, vol.52, issue.6, pp.951-952, 2010.
DOI : 10.1016/j.jhep.2010.02.002

S. Nielsen, M. Bassendine, A. Burt, C. Martin, W. Pumeechockchai et al., Association between Hepatitis C Virus and Very-Low-Density Lipoprotein (VLDL)/LDL Analyzed in Iodixanol Density Gradients, Journal of Virology, vol.80, issue.5, pp.2418-2428, 2006.
DOI : 10.1128/JVI.80.5.2418-2428.2006

A. Op-de-beeck and J. Dubuisson, Topology of hepatitis C virus envelope glycoproteins, Reviews in Medical Virology, vol.277, issue.4, 2003.
DOI : 10.1002/rmv.391

R. Out, M. Hoekstra, J. Spijkers, J. Kruijt, M. Van-eck et al., Scavenger receptor class B type I is solely responsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice, The Journal of Lipid Research, vol.45, issue.11, pp.2088-2095, 2004.
DOI : 10.1194/jlr.M400191-JLR200

D. Owen, H. Huang, J. Ye, M. Gale, and J. , Apolipoprotein E on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptor, Virology, vol.394, issue.1, pp.99-108, 2009.
DOI : 10.1016/j.virol.2009.08.037

C. Packard and J. Shepherd, Lipoprotein Heterogeneity and Apolipoprotein B Metabolism, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.17, issue.12, 1997.
DOI : 10.1161/01.ATV.17.12.3542

J. Pawlotsky, Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus, Hepatology, vol.53, issue.5, pp.1742-1751, 2011.
DOI : 10.1002/hep.24262

P. Pileri, Y. Uematsu, S. Campagnoli, G. Galli, F. Falugi et al., Binding of Hepatitis C Virus to CD81, Science, vol.282, issue.5390, pp.938-941, 1998.
DOI : 10.1126/science.282.5390.938

A. Ploss, M. Evans, V. Gaysinskaya, M. Panis, H. You et al., Human occludin is a hepatitis C virus entry factor required for infection of mouse cells, Nature, vol.309, issue.7231, pp.882-886, 2009.
DOI : 10.1038/nature07684

S. Pohlmann, J. Zhang, F. Baribaud, Z. Chen, G. Leslie et al., Hepatitis C Virus Glycoproteins Interact with DC-SIGN and DC-SIGNR, Journal of Virology, vol.77, issue.7, pp.4070-4080, 2003.
DOI : 10.1128/JVI.77.7.4070-4080.2003

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC150620

S. Polyak, C. Morishima, M. Shuhart, C. Wang, Y. Liu et al., Inhibition of T-Cell Inflammatory Cytokines, Hepatocyte NF-??B Signaling, and HCV Infection by Standardized Silymarin, Gastroenterology, vol.132, issue.5, pp.1925-1936, 2007.
DOI : 10.1053/j.gastro.2007.02.038

J. Bukh, Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization, J Virol, vol.85, pp.2224-2234, 2011.

P. Donaldson, Apolipoprotein epsilon3 allele is associated with persistent hepatitis C virus infection, Gut, vol.55, pp.715-718, 2006.

A. Prince, T. Huima-byron, T. Parker, and D. Levine, Visualization of hepatitis C virions and putative defective interfering particles isolated from low-density lipoproteins, Journal of Viral Hepatitis, vol.68, issue.1, pp.11-17, 1996.
DOI : 10.1126/science.1279801

S. Hubscher and J. Mckeating, Hepatitis C virus receptor expression in normal and diseased liver tissue, Hepatology, vol.47, pp.418-427, 2008.

P. Roingeard, C. Hourioux, E. Blanchard, and G. Prensier, Hepatitis C virus budding at lipid droplet-associated ER membrane visualized by 3D electron microscopy, Histochemistry and Cell Biology, vol.102, issue.3, pp.561-566, 2008.
DOI : 10.1007/s00418-008-0447-2

URL : https://hal.archives-ouvertes.fr/inserm-00285203

G. Rothblat and M. Phillips, High-density lipoprotein heterogeneity and function in reverse cholesterol transport, Current Opinion in Lipidology, vol.21, issue.3, pp.229-238, 2010.
DOI : 10.1097/MOL.0b013e328338472d

K. Rutter, T. Scherzer, S. Beinhardt, H. Kerschner, A. Stattermayer et al., Intravenous silibinin as ???rescue treatment??? for on-treatment non-responders to pegylated interferon/ribavirin combination therapy, Antiviral Therapy, vol.16, issue.8, pp.1327-1333, 2011.
DOI : 10.3851/IMP1942

K. Rye, C. Bursill, G. Lambert, F. Tabet, and P. Barter, The metabolism and anti-atherogenic properties of HDL, The Journal of Lipid Research, vol.50, issue.Supplement, pp.195-200, 2009.
DOI : 10.1194/jlr.R800034-JLR200

S. Lund-katz, Characterization of the heparin binding sites in human apolipoprotein E, 2003.

B. Saunier, M. Triyatni, L. Ulianich, P. Maruvada, Y. P. Kohn et al., Role of the Asialoglycoprotein Receptor in Binding and Entry of Hepatitis C Virus Structural Proteins in Cultured Human Hepatocytes, Journal of Virology, vol.77, issue.1, pp.546-559, 2003.
DOI : 10.1128/JVI.77.1.546-559.2003

R. Cortese and A. Vitelli, The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus, The EMBO journal, vol.21, pp.5017-5025, 2002.

N. Shachter, Apolipoproteins C-I and C-III as important modulators of lipoprotein metabolism, Current Opinion in Lipidology, vol.12, issue.3, pp.297-304, 2001.
DOI : 10.1097/00041433-200106000-00009

G. Shelness and J. Sellers, Very-low-density lipoprotein assembly and secretion, Current Opinion in Lipidology, vol.12, issue.2, pp.151-157, 2001.
DOI : 10.1097/00041433-200104000-00008

H. Takaku and K. Shimotohno, Lipoprotein lipase and hepatic triglyceride lipase reduce the infectivity of hepatitis C virus (HCV) through their catalytic activities on HCV-associated lipoproteins, Virology, vol.407, pp.152-159, 2010.

M. Skov, C. Tonnesen, G. Hansen, and E. Danielsen, Dietary cholesterol induces trafficking of intestinal Niemann-Pick Type C1 Like 1 from the brush border to endosomes, AJP: Gastrointestinal and Liver Physiology, vol.300, issue.1, 2011.
DOI : 10.1152/ajpgi.00344.2010

D. Steinmann, H. Barth, B. Gissler, P. Schürmann, M. Adah et al., Inhibition of Hepatitis C Virus-Like Particle Binding to Target Cells by Antiviral Antibodies in Acute and Chronic Hepatitis C, Journal of Virology, vol.78, issue.17, pp.9030-9040, 2004.
DOI : 10.1128/JVI.78.17.9030-9040.2004

A. Syder, H. Lee, M. Zeisel, J. Grove, E. Soulier et al., Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitors, Journal of Hepatology, vol.54, issue.1, pp.48-55, 2011.
DOI : 10.1016/j.jhep.2010.06.024

R. Thomssen, S. Bonk, C. Propfe, K. Heermann, H. Koechel et al., Association of hepatitis C virus in human sera with ?-lipoprotein, Medical Microbiology and Immunology, vol.65, issue.5, pp.293-300, 1992.
DOI : 10.1007/BF00198849

R. Thomssen, S. Bonk, and A. Thiele, Density heterogeneities of hepatitis C virus in human sera due to the binding of beta-lipoproteins and immunoglobulins, Medical microbiology and immunology, vol.182, pp.329-334, 1993.

J. Timpe, Z. Stamataki, A. Jennings, K. Hu, M. Farquhar et al., Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies, Hepatology, vol.7, issue.1, pp.17-24, 2008.
DOI : 10.1002/hep.21959

M. Triyatni, B. Saunier, P. Maruvada, A. Davis, L. Ulianich et al., Interaction of Hepatitis C Virus-Like Particles and Cells: a Model System for Studying Viral Binding and Entry, Journal of Virology, vol.76, issue.18, pp.9335-9344, 2002.
DOI : 10.1128/JVI.76.18.9335-9344.2002

M. Trotard, C. Lepere-douard, M. Regeard, C. Piquet-pellorce, D. Lavillette et al., Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening, The FASEB Journal, vol.23, issue.11, pp.3780-3789, 2009.
DOI : 10.1096/fj.09-131920

URL : https://hal.archives-ouvertes.fr/hal-00676358

D. Tscherne, M. Evans, T. Von-hahn, C. Jones, Z. Stamataki et al., Superinfection Exclusion in Cells Infected with Hepatitis C Virus, Journal of Virology, vol.81, issue.8, pp.3693-3703, 2007.
DOI : 10.1128/JVI.01748-06

D. Tscherne, C. Jones, M. Evans, B. Lindenbach, J. Mckeating et al., Time- and Temperature-Dependent Activation of Hepatitis C Virus for Low-pH-Triggered Entry, Journal of Virology, vol.80, issue.4, pp.1734-1741, 2006.
DOI : 10.1128/JVI.80.4.1734-1741.2006

M. Valasek, J. Weng, P. Shaul, R. Anderson, and J. Repa, Caveolin-1 Is Not Required for Murine Intestinal Cholesterol Transport, Journal of Biological Chemistry, vol.280, issue.30, pp.28103-28109, 2005.
DOI : 10.1074/jbc.M504609200

S. Vancompernolle, A. Wiznycia, J. Rush, M. Dhanasekaran, P. Baures et al., Small molecule inhibition of hepatitis C virus E2 binding to CD81, Virology, vol.314, issue.1, pp.371-380, 2003.
DOI : 10.1016/S0042-6822(03)00406-9

T. Vanwolleghem, J. Bukh, P. Meuleman, I. Desombere, J. Meunier et al., Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver???chimeric mice from infection with a homologous hepatitis C virus strain, Hepatology, vol.104, issue.6, 2008.
DOI : 10.1002/hep.22244

G. Vieyres, J. Dubuisson, and A. Patel, Characterization of antibody-mediated neutralization directed against the hypervariable region 1 of hepatitis C virus E2 glycoprotein, Journal of General Virology, vol.92, issue.3, 2011.
DOI : 10.1099/vir.0.028092-0

C. Voisset, N. Callens, E. Blanchard, O. De-beeck, A. Dubuisson et al., High Density Lipoproteins Facilitate Hepatitis C Virus Entry through the Scavenger Receptor Class B Type I, Journal of Biological Chemistry, vol.280, issue.9, pp.7793-7799, 2005.
DOI : 10.1074/jbc.M411600200

URL : https://hal.archives-ouvertes.fr/hal-00105456

C. Voisset, M. Lavie, F. Helle, O. De-beeck, A. Bilheu et al., Ceramide enrichment of the plasma membrane induces CD81 internalization and inhibits hepatitis C virus entry, Cellular Microbiology, vol.43, issue.3, pp.606-617, 2008.
DOI : 10.1073/pnas.0503596102

T. Von-hahn, B. Lindenbach, A. Boullier, O. Quehenberger, M. Paulson et al., Oxidized low-density lipoprotein inhibits hepatitis C virus cell entry in human hepatoma cells, Hepatology, vol.122, issue.5, pp.932-942, 2006.
DOI : 10.1002/hep.21139

T. Von-hahn and C. Rice, Hepatitis C Virus Entry, Journal of Biological Chemistry, vol.283, issue.7, pp.3689-3693, 2008.
DOI : 10.1074/jbc.R700024200

H. Wang, D. Gilham, and R. Lehner, Proteomic and Lipid Characterization of Apolipoprotein B-free Luminal Lipid Droplets from Mouse Liver Microsomes: IMPLICATIONS FOR VERY LOW DENSITY LIPOPROTEIN ASSEMBLY, Journal of Biological Chemistry, vol.282, issue.45, pp.33218-33226, 2007.
DOI : 10.1074/jbc.M706841200

J. Witteveldt, M. Evans, J. Bitzegeio, G. Koutsoudakis, A. Owsianka et al., CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells, Journal of General Virology, vol.90, issue.1, pp.48-58, 2009.
DOI : 10.1099/vir.0.006700-0

S. Wunschmann, J. Medh, D. Klinzmann, W. Schmidt, and J. Stapleton, Characterization of Hepatitis C Virus (HCV) and HCV E2 Interactions with CD81 and the Low-Density Lipoprotein Receptor, Journal of Virology, vol.74, issue.21, pp.10055-10062, 2000.
DOI : 10.1128/JVI.74.21.10055-10062.2000

M. Yamamoto, H. Aizaki, M. Fukasawa, T. Teraoka, T. Miyamura et al., Structural requirements of virion-associated cholesterol for infectivity, buoyant density and apolipoprotein association of hepatitis C virus, Journal of General Virology, vol.92, issue.9, pp.2082-2087, 2011.
DOI : 10.1099/vir.0.032391-0

W. Yang, C. Qiu, N. Biswas, J. J. Watkins, S. Montelaro et al., Correlation of the Tight Junction-like Distribution of Claudin-1 to the Cellular Tropism of Hepatitis C Virus, Journal of Biological Chemistry, vol.283, issue.13, pp.8643-8653, 2008.
DOI : 10.1074/jbc.M709824200

M. Zahid, M. Turek, F. Xiao, V. Thi, M. Guerin et al., The post-binding activity of scavenger receptor BI mediates initiation of hepatitis C virus infection and viral dissemination, Zeisel MB Hepatology, 2012.

M. Zeisel, I. Fofana, S. Fafi-kremer, and T. Baumert, Hepatitis C virus entry into hepatocytes: Molecular mechanisms and targets for antiviral therapies, Journal of Hepatology, vol.54, issue.3, pp.566-576, 2011.
DOI : 10.1016/j.jhep.2010.10.014

URL : https://hal.archives-ouvertes.fr/inserm-00701487

D. Jaeck, M. Doffoel, C. Royer, E. Soulier, E. Schvoerer et al., Scavenger receptor BI is a key host factor for Hepatitis C virus infection required for an entry step closely linked to CD81, Hepatology, vol.46, pp.1722-1731, 2007.

A. Zheng, F. Yuan, Y. Li, F. Zhu, P. Hou et al., Claudin-6 and Claudin-9 Function as Additional Coreceptors for Hepatitis C Virus, Journal of Virology, vol.81, issue.22, pp.12465-12471, 2007.
DOI : 10.1128/JVI.01457-07

C. Zheng, C. Khoo, J. Furtado, K. Ikewaki, and F. Sacks, Dietary monounsaturated fat activates metabolic pathways for triglyceride-rich lipoproteins that involve apolipoproteins E and C-III, The American journal of clinical nutrition, vol.88, pp.272-281, 2008.