Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes using monoclonal antibodies.

Isabel Fofana; Laetitia Zona; Christine Thumann; Laura Heydmann; Sarah Durand; Joachim Lupberger; Hubert Blum; Patrick Pessaux; Claire Gondeau; Gary Reynolds; Jane Mckeating; Fritz Grunert; John Thompson; Mirjam Zeisel; Thomas Baumert

doi:10.1128/JVI.01691-13

Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes using monoclonal antibodies.

Isabel Fofana ¹ Laetitia Zona ¹ Christine Thumann ¹ Laura Heydmann ¹ Sarah Durand ¹ Joachim Lupberger ^{1, 2} Hubert Blum ² Patrick Pessaux ^{1, 3} Claire Gondeau ⁴ Gary Reynolds ⁵ Jane Mckeating ⁵ Fritz Grunert ⁶ John Thompson ⁶ Mirjam Zeisel ¹ Thomas Baumert ^{1, 3, *}

* Auteur correspondant

1 Interactions Virus-Hôte et Maladies Hépatiques

2 Department of Medicine II

3 Pôle Hépato- digestif

4 Cellules souches normales et cancéreuses

5 NIHR Liver Biomedical Research Unit

6 Aldevron GmbH

Abstract : : The relevance of claudin-6 and claudin-9 in hepatitis C virus (HCV) entry remains elusive. We produced claudin-6 or claudin-9 specific monoclonal antibodies that inhibit HCV entry into non-hepatic cells expressing exogenous claudin-6 or claudin-9. These antibodies had no effect on HCV infection of hepatoma cells or primary hepatocytes. Thus although claudin-6 and claudin-9 can serve as entry factors in cell lines, HCV infection into human hepatocytes is not dependent on claudin-6 and claudin-9.

Type de document :

Article dans une revue

Journal of Virology, American Society for Microbiology, 2013, epub ahead of print. 〈10.1128/JVI.01691-13〉

Domaine :

Sciences du Vivant [q-bio] / Médecine humaine et pathologie / Hépatologie et Gastroentérologie

Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00850891
Contributeur : Thomas Baumert <>
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Dernière modification le : lundi 18 décembre 2017 - 01:02:16
Document(s) archivé(s) le : mercredi 5 avril 2017 - 20:32:15

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Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes using monoclonal antibodies.

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Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes using monoclonal antibodies.

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Citation

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687

410

Contact