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Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes using monoclonal antibodies.

Abstract : : The relevance of claudin-6 and claudin-9 in hepatitis C virus (HCV) entry remains elusive. We produced claudin-6 or claudin-9 specific monoclonal antibodies that inhibit HCV entry into non-hepatic cells expressing exogenous claudin-6 or claudin-9. These antibodies had no effect on HCV infection of hepatoma cells or primary hepatocytes. Thus although claudin-6 and claudin-9 can serve as entry factors in cell lines, HCV infection into human hepatocytes is not dependent on claudin-6 and claudin-9.
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https://www.hal.inserm.fr/inserm-00850891
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Submitted on : Friday, January 31, 2014 - 5:07:37 PM
Last modification on : Thursday, November 26, 2020 - 3:56:04 PM
Long-term archiving on: : Wednesday, April 5, 2017 - 8:32:15 PM

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Isabel Fofana, Laetitia Zona, Christine Thumann, Laura Heydmann, Sarah Durand, et al.. Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes using monoclonal antibodies.. Journal of Virology, American Society for Microbiology, 2013, epub ahead of print. ⟨10.1128/JVI.01691-13⟩. ⟨inserm-00850891⟩

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