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Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver disease.

Abstract : Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatitis C infection associates with lipid and lipoprotein metabolism disorders such as hepatic steatosis, hypobetalipoproteinemia, and hypocholesterolemia. Furthermore, virus production is dependent on hepatic very-low-density lipoprotein (VLDL) assembly, and circulating virions are physically associated with lipoproteins in complexes termed lipoviral particles. Evidence has indicated several functional roles for the formation of these complexes, including co-opting of lipoprotein receptors for attachment and entry, concealing epitopes to facilitate immune escape, and hijacking host factors for HCV maturation and secretion. Here, we review the evidence surrounding pathogenesis of the hepatitis C infection regarding lipoprotein engagement, cholesterol and triglyceride regulation, and the molecular mechanisms underlying these effects.
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https://www.hal.inserm.fr/inserm-00850889
Contributor : Thomas F. Baumert Connect in order to contact the contributor
Submitted on : Friday, August 9, 2013 - 2:00:54 PM
Last modification on : Thursday, November 26, 2020 - 3:56:04 PM
Long-term archiving on: : Sunday, November 10, 2013 - 4:17:50 AM

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Daniel Felmlee, Mohamed Lamine Hafirassou, Mathieu Lefevre, Thomas Baumert, Catherine Schuster. Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver disease.. Viruses, MDPI, 2013, 5 (5), pp.1292-324. ⟨10.3390/v5051292⟩. ⟨inserm-00850889⟩

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