2045-7022-3-S3-P162045-7022 Poster presentation <p>Long term nutritional outcome of children fed an amino-acid formula</p> ColsonD MichaudB SoulainesP DupontC

Nutritia Nutrition Clinique, Saint Ouen, France

Laboratoire d’Immunologie Biologie INSERM U1013, Paris, France

Hopital Necker Enfants-Malades, Paris, France

 Clinical and Translational Allergy <p>Food Allergy and Anaphylaxis Meeting (FAAM 2013): Abstracts</p>Karin Hoffmann-Sommergruber, Antonella Muraro, Berber Vlieg-Boerstra, Carsten Bindslev-Jensen, Anthony Dubois, Phillippe Eigenmann, Susanne Halken, Giovanni Pajno, Lars K Poulsen, Graham Roberts, Ronald van Ree, Valerie Verhasselt and Thomas WerfelPublication of this supplement was funded by the European Academy of Allergy and Clinical Immunology (EAACI). The Supplement Editors declare that they have no competing interests.Meeting abstracts<p>Food Allergy and Anaphylaxis Meeting (FAAM 2013)</p>Nice, France7-9 February 2013http://www.eaaci-faam.org/2045-7022 2013 3 Suppl 3 P16 http://www.ctajournal.com/content/3/S3/P16 10.1186/2045-7022-3-S3-P16 2572013 2013Colson et al; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Background

Some cases of cow’s milk protein allergy (CMPA) require the use of an amino-acids based formula (AAF), with a with a protein level higher than in standard infant formulas. This study assessed the long term consequences of an AAF-based elimination diet on the clinical and biological outcome of CMPA children.

Methods

Retrospective analysis of consecutive (2004-2010) patients diagnosed with CMPA (digestive/cutaneous/respiratory symptoms) in a food allergy reference center (Cohort Arsène,n°DC-2009-955), through a telephone survey (Nov2011–Feb2012). Children were enrolled if having adhered to dietetic recommendations, and fed with ≥500mL/day of AAF (Neocate®) or extensive whey hydrolysate-based formula (eWHF, Pepti-Junior®) for ≥6mo, starting either before age 6 months (AAF1, eWHF1)), between ages >6 and 12 months (AAF2) or after age 12 (AAF3).

Results

From a longitudinal data set of 515 children, 134 responded to enrolment criteria, 102 fed with AAF and 32 fed with eWHF. At survey, BMI (percentiles) in males was in the normal range and identical whether fed by AAF or eWHF. In females, BMI was significantly lower in AAF1vs eWHF1 (p 0.04). Ferritin and hemoglobin levels were within the normal range in all groups.

<p>Table 1</p>

Age at survey (months) (Mean, SD)

AAF1(n=41)66.02±26.5

eHWF1(n=20)86.55±24

AAF2(n=42)62.4±34.3

AAF3(n=20)73.5±28.7

BMI percentile in males at survey: (Mean, SD)

42.85±28.79

44.17±30.07

42.73±29.37

31±25.09

BMI percentile in females at survey (Mean, SD)

31.91±38

64.16±26.07

31.54±24.95

33.85±22.68

Ferritin in males/females (Mean, SD)

26.7±13.6/27±17

11.98±0.8/12.6±0.4

11.64±0.6/12.7±0.4

30.6±14.1/26.5±0.5

Hemoglobin in males/females (Mean, SD)

31.7±9.8/35±8.6

11.05±0.55/35.12±30.3

12.38±0.75/11.6±0.6

34.3±12.28/11.36±1.8

Conclusion

This study suggests that feeding CMPA children with>500 mL/day of AAF for >15 mo showed a good nutritional outcome with an appropriate anthropomorphic parameters and iron status.

Disclosure of interest

D Colson: Grant/research support from Nutricia Nutrition Clinique, B Michaud: None declared, P Soulaines: None declared, C Dupont: None declared.