J. Folkman, Tumor angiogenesis: therapeutic implications, N Engl J Med, vol.285, pp.1182-1186, 1971.

M. Gimbrone, . Jr, S. Leapman, R. Cotran, and J. Folkman, TUMOR DORMANCY IN VIVO BY PREVENTION OF NEOVASCULARIZATION, Journal of Experimental Medicine, vol.136, issue.2, pp.261-276, 1972.
DOI : 10.1084/jem.136.2.261

J. Folkman, Role of angiogenesis in tumor growth and metastasis, Seminars in Oncology, vol.29, issue.6Q, pp.15-18, 2002.
DOI : 10.1053/sonc.2002.37263

J. Folkman, Angiogenesis: an organizing principle for drug discovery?, Nature Reviews Drug Discovery, vol.57, issue.5, pp.273-286, 2007.
DOI : 10.1038/nrd2115

B. Teicher, E. Sotomayor, and Z. Huang, Antiangiogenic agents potentiate cytotoxic cancer therapies against primary andmetastatic disease, Cancer Res, vol.52, pp.6702-6706, 1992.

Y. Kakeji and B. Teicher, Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents, Investigational New Drugs, vol.15, issue.1, pp.39-48, 1997.
DOI : 10.1023/A:1005718628223

J. Denekamp, Endothelial cell proliferation as a novel approach to targeting tumour therapy, British Journal of Cancer, vol.45, issue.1, pp.136-139, 1982.
DOI : 10.1038/bjc.1982.16

J. Denekamp, Angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy, The British Journal of Radiology, vol.66, issue.783, pp.181-196, 1993.
DOI : 10.1259/0007-1285-66-783-181

R. Kerbel, Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents, BioEssays, vol.165, issue.1, pp.31-36, 1991.
DOI : 10.1002/bies.950130106

J. Biedler and H. Riehm, Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies, Cancer Res, vol.30, pp.1174-1184, 1970.

D. Harrison, Molecular mechanisms of drug resistance in tumours, The Journal of Pathology, vol.362, issue.1, pp.7-12, 1995.
DOI : 10.1002/path.1711750103

D. Longley and P. Johnston, Molecular mechanisms of drug resistance, The Journal of Pathology, vol.1603, issue.2, pp.275-292, 2005.
DOI : 10.1002/path.1706

M. Gottesman, T. Fojo, and S. Bates, MULTIDRUG RESISTANCE IN CANCER: ROLE OF ATP-DEPENDENT TRANSPORTERS, Nature Reviews Cancer, vol.2, issue.1, pp.48-58, 2002.
DOI : 10.1038/nrc706

M. Dean, The Genetics of ATP???Binding Cassette Transporters, Methods Enzymol, vol.400, pp.409-429, 2005.
DOI : 10.1016/S0076-6879(05)00024-8

R. Deeley, C. Westlake, and S. Cole, Transmembrane Transport of Endo- and Xenobiotics by Mammalian ATP-Binding Cassette Multidrug Resistance Proteins, Physiological Reviews, vol.86, issue.3, pp.849-899, 2006.
DOI : 10.1152/physrev.00035.2005

R. Juliano and V. Ling, A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.455, issue.1, pp.152-162, 1976.
DOI : 10.1016/0005-2736(76)90160-7

C. Cordon-cardo, O. Brien, J. Boccia, J. Casals, D. Bertino et al., Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues., Journal of Histochemistry & Cytochemistry, vol.38, issue.9, pp.1277-1287, 1990.
DOI : 10.1177/38.9.1974900

M. Gottesman and I. Pastan, Biochemistry of Multidrug Resistance Mediated by the Multidrug Transporter, Annual Review of Biochemistry, vol.62, issue.1, pp.385-427, 1993.
DOI : 10.1146/annurev.bi.62.070193.002125

K. Linton and C. Higgins, Structure and function of ABC transporters: the ATP switch provides flexible control, Pfl??gers Archiv - European Journal of Physiology, vol.121, issue.5, pp.555-567, 2007.
DOI : 10.1007/s00424-006-0126-x

C. Cordon-cardo, O. Brien, J. Casals, D. Rittman-grauer, L. Biedler et al., Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites., Proceedings of the National Academy of Sciences, vol.86, issue.2, pp.695-698, 1989.
DOI : 10.1073/pnas.86.2.695

B. Sikic, Modulation of multidrug resistance: a paradigm for translational clinical research, Oncology, vol.13, pp.183-190, 1999.

B. Sikic, G. Fisher, B. Lum, J. Halsey, L. Beketic-oreskovic et al., Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein, Cancer Chemotherapy and Pharmacology, vol.40, issue.0, pp.13-19, 1997.
DOI : 10.1007/s002800051055

J. Allen, R. Brinkhuis, L. Van-deemter, J. Wijnholds, and A. Schinkel, Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance, Cancer Res, vol.60, pp.5761-5766, 2000.

J. Smit, A. Schinkel, M. Muller, B. Weert, and D. Meijer, gene disruption, Hepatology, vol.55, issue.4, pp.1056-1063, 1998.
DOI : 10.1002/hep.510270422

M. Dean, A. Rzhetsky, and R. Allikmets, The Human ATP-Binding Cassette (ABC) Transporter Superfamily, Genome Research, vol.11, issue.7, pp.1156-1166, 2001.
DOI : 10.1101/gr.GR-1649R

K. Ueda, C. Cardarelli, M. Gottesman, and I. Pastan, Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine., Proceedings of the National Academy of Sciences, vol.84, issue.9, pp.3004-3008, 1987.
DOI : 10.1073/pnas.84.9.3004

M. Kuwano, S. Toh, T. Uchiumi, H. Takano, K. Kohno et al., Multidrug resistance-associated protein subfamily transporters and drug resistance, Anticancer Drug Des, vol.14, pp.123-131, 1999.

Y. Xiong, H. Sun, W. Zhang, X. Zhu, P. Zhuang et al., Human Hepatocellular Carcinoma Tumor-derived Endothelial Cells Manifest Increased Angiogenesis Capability and Drug Resistance Compared with Normal Endothelial Cells, Clinical Cancer Research, vol.15, issue.15, pp.4838-4846, 2009.
DOI : 10.1158/1078-0432.CCR-08-2780

K. Natarajan, Y. Xie, M. Baer, and D. Ross, Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance, Biochemical Pharmacology, vol.83, issue.8, pp.1084-1103, 2012.
DOI : 10.1016/j.bcp.2012.01.002

J. Scherrmann, Expression and function of multidrug resistance transporters at the blood???brain barriers, Expert Opinion on Drug Metabolism & Toxicology, vol.1, issue.8, pp.233-246, 2005.
DOI : 10.2174/1381612043384844

S. Seetharaman, M. Barrand, L. Maskell, and R. Scheper, Multidrug Resistance-Related Transport Proteins in Isolated Human Brain Microvessels and in Cells Cultured from These Isolates, Journal of Neurochemistry, vol.70, issue.3, pp.1151-1159, 1998.
DOI : 10.1046/j.1471-4159.1998.70031151.x

R. Bendayan, P. Ronaldson, D. Gingras, and M. Bendayan, In Situ Localization of P-glycoprotein (ABCB1) in Human and Rat Brain, Journal of Histochemistry and Cytochemistry, vol.54, issue.10, pp.1159-1167, 2006.
DOI : 10.1369/jhc.5A6870.2006

G. Lee, K. Babakhanian, M. Ramaswamy, A. Prat, K. Wosik et al., Expression of the ATP-binding Cassette Membrane Transporter, ABCG2, in Human and Rodent Brain Microvessel Endothelial and Glial Cell Culture Systems, Pharmaceutical Research, vol.54, issue.7, pp.1262-1274, 2007.
DOI : 10.1007/s11095-007-9244-1

Y. Zhang, H. Han, W. Elmquist, and D. Miller, Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells, Brain Research, vol.876, issue.1-2, pp.148-153, 2000.
DOI : 10.1016/S0006-8993(00)02628-7

S. Dauchy, F. Miller, P. Couraud, R. Weaver, B. Weksler et al., Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells, Biochemical Pharmacology, vol.77, issue.5, pp.897-909, 2009.
DOI : 10.1016/j.bcp.2008.11.001
URL : https://hal.archives-ouvertes.fr/hal-00531837

K. Hida, K. Akiyama, N. Ohga, N. Maishi, and Y. Hida, Tumour endothelial cells acquire drug resistance in a tumour microenvironment, Journal of Biochemistry, vol.153, issue.3, pp.243-249, 2013.
DOI : 10.1093/jb/mvs152

K. Akiyama, N. Ohga, Y. Hida, T. Kawamoto, Y. Sadamoto et al., Tumor Endothelial Cells Acquire Drug Resistance by MDR1 Up-Regulation via VEGF Signaling in Tumor Microenvironment, The American Journal of Pathology, vol.180, issue.3, pp.1283-1293
DOI : 10.1016/j.ajpath.2011.11.029

V. Trochon-joseph, D. Martel-renoir, L. Mir, A. Thomaïdis, P. Opolon et al., Evidence of Antiangiogenic and Antimetastatic Activities of the Recombinant Disintegrin Domain of Metargidin, Cancer Research, vol.64, issue.6, pp.2062-2069, 2004.
DOI : 10.1158/0008-5472.CAN-03-3272
URL : https://hal.archives-ouvertes.fr/hal-00320014

E. Jaffe, R. Nachman, C. Becker, and C. Minick, Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA, Journal of Clinical Investigation, vol.52, issue.11, pp.2745-2756, 1973.
DOI : 10.1172/JCI107470

B. Ji, L. He, and G. Liu, Reversal of p-glycoprotein-mediated multidrug resistance by CJX1, an amlodipine derivative, in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells, Life Sciences, vol.77, issue.18, pp.2221-2232, 2005.
DOI : 10.1016/j.lfs.2004.12.050

A. Schinkel and J. Jonker, Mammalian drug efflux transporters of the ATP bindingcassette(ABC)family:anoverview, Adv Drug Deliv Rev, vol.55, pp.23-29, 2003.

V. Goler-baron and Y. Assaraf, Structure and Function of ABCG2-Rich Extracellular Vesicles Mediating Multidrug Resistance, PLoS ONE, vol.367, issue.1, p.16007, 2011.
DOI : 10.1371/journal.pone.0016007.s006

T. Nakanishi, Drug transporters as targets for cancer chemotherapy, Cancer Genomics Proteomics, vol.4, pp.241-254, 2007.

N. Frank, T. Schatton, and M. Frank, The therapeutic promise of the cancer stem cell concept, Journal of Clinical Investigation, vol.120, issue.1, pp.41-50, 2010.
DOI : 10.1172/JCI41004

R. Jain, Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy, Nature Medicine, vol.7, issue.9, pp.987-989, 2001.
DOI : 10.1038/nm0901-987

B. Baguley, Multidrug Resistance in Cancer, Methods Mol Biol, vol.596, pp.11-14, 2010.
DOI : 10.1007/978-1-60761-416-6_1

J. Zhang, Use of arrays to investigate the contribution of ATP-binding cassette transporters to drug resistance in cancer chemotherapy and prediction of chemosensitivity, Cell Research, vol.281, issue.4, pp.311-323, 2007.
DOI : 10.1038/cr.2007.15

A. Dudley and M. Klagsbrun, Tumor Endothelial Cells Join the Resistance, Clinical Cancer Research, vol.15, issue.15, pp.4787-4789, 2009.
DOI : 10.1158/1078-0432.CCR-09-0902

. Huang, Induction of acquired drug resistance in endothelial cells and its involvement in anticancer therapy, Journal of Hematology & Oncology, vol.6, issue.1, p.49, 2013.
DOI : 10.1158/1078-0432.CCR-09-0902
URL : https://hal.archives-ouvertes.fr/inserm-00845842