Signaling pathway switch in breast cancer.

Abstract : Next generation sequencing studies have drawn the general landscape of breast cancers and identified hundreds of new, actual therapeutic targets. Two major signaling pathways seem to be altered in a vast proportion of breast cancers. The PI3 kinase/AKT pathway is activated and the JUN/MAPK pathway is repressed. Via the regulation of the cell cycle this metabolic switch impacts on the balance between self-renewal, proliferation and differentiation of the tumor-initiating cells.
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Cancer Cell International, BioMed Central, 2013, 13 (1), pp.66. 〈10.1186/1475-2867-13-66〉
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Arnaud Guille, Max Chaffanet, Daniel Birnbaum. Signaling pathway switch in breast cancer.. Cancer Cell International, BioMed Central, 2013, 13 (1), pp.66. 〈10.1186/1475-2867-13-66〉. 〈inserm-00844782〉

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