Signaling pathway switch in breast cancer. - Archive ouverte HAL Access content directly
Journal Articles Cancer Cell International Year : 2013

Signaling pathway switch in breast cancer.

(1) , (1) , (1)


Next generation sequencing studies have drawn the general landscape of breast cancers and identified hundreds of new, actual therapeutic targets. Two major signaling pathways seem to be altered in a vast proportion of breast cancers. The PI3 kinase/AKT pathway is activated and the JUN/MAPK pathway is repressed. Via the regulation of the cell cycle this metabolic switch impacts on the balance between self-renewal, proliferation and differentiation of the tumor-initiating cells.
Fichier principal
Vignette du fichier
1475-2867-13-66.pdf (589.58 Ko) Télécharger le fichier
Vignette du fichier
1475-2867-13-66.xml (23.3 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Format : Other

Dates and versions

inserm-00844782 , version 1 (15-07-2013)



Arnaud Guille, Max Chaffanet, Daniel Birnbaum. Signaling pathway switch in breast cancer.. Cancer Cell International, 2013, 13 (1), pp.66. ⟨10.1186/1475-2867-13-66⟩. ⟨inserm-00844782⟩
138 View
197 Download



Gmail Facebook Twitter LinkedIn More