Comparative analysis of anti-toxoplasmic activity of antipsychotic drugs and valproate. - Archive ouverte HAL Access content directly
Journal Articles European Archives of Psychiatry and Clinical Neuroscience Year : 2014

Comparative analysis of anti-toxoplasmic activity of antipsychotic drugs and valproate.

(1) , (2) , (1) , (3) , (1) , (1) , (4)
1
2
3
4

Abstract

Recent studies have shown a strong link between Toxoplasma gondii infection and psychiatric disorders, especially schizophrenia and bipolar disorders (odd ratio ≈2.7 for each disorder). Antipsychotic drugs and mood stabilizers may have anti-toxoplasmic activity that potentially may be associated with better effectiveness in these disorders, but previous results have been few in number and conflicting. We therefore sought to determine which daily prescribed antipsychotics and mood stabilizer have the best anti-toxoplasmic activity during the development phase of the parasite. In the present study, we examined the effects of commonly used antipsychotic drugs (amisulpride, cyamemazine, fluphenazine, haloperidol, levomepromazine, loxapine, olanzapine, risperidone and tiapride) and one mood-stabilizing agent (valproate) on toxoplasmic activity. We replicated that fluphenazine has a high anti-toxoplasmic activity, but it does not seem to be a phenothiazine-specific class effect: indeed, we found that another first-generation antipsychotic, zuclopenthixol, has a high anti-toxoplasmic activity. Valproate, tiapride and amisulpride have no anti-toxoplasmic activity on parasite growth, and the other antipsychotic drugs showed low or intermediate anti-toxoplasmic activity. As it is not possible to know the intracellular concentrations of antipsychotics in the brain, further clinical studies are warranted to determine whether these in vitro findings have potential implications in treatment of toxo-positive patients with schizophrenia. These findings may be potentially relevant for the choice of the first-line antipsychotic drug or mood stabilizer in previously infected patients.
Fichier principal
Vignette du fichier
ANTIPSYCHOTIC_ANTITOXO_Fig1.pdf (93.02 Ko) Télécharger le fichier
Vignette du fichier
ANTIPSYCHOTIC_ANTITOXO_manuscript_13_05_13.pdf (136.82 Ko) Télécharger le fichier
Vignette du fichier
ANTIPSYCHOTIC_ANTITOXO_TABLE_1.pdf (64.97 Ko) Télécharger le fichier
Vignette du fichier
ANTIPSYCHOTIC_ANTITOXO_Table_2jfd.pdf (4.91 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)

Dates and versions

inserm-00844714 , version 1 (04-06-2014)

Identifiers

Cite

Guillaume Fond, Alexandra Macgregor, Marion Leboyer, Ryad Tamouza, Nora Hamdani, et al.. Comparative analysis of anti-toxoplasmic activity of antipsychotic drugs and valproate.. European Archives of Psychiatry and Clinical Neuroscience, 2014, 264 (2), pp.179-83. ⟨10.1007/s00406-013-0413-4⟩. ⟨inserm-00844714⟩
656 View
945 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More