Dolosigranulum pigrum keratitis: a three-case series - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue BMC Ophthalmology Année : 2013

Dolosigranulum pigrum keratitis: a three-case series

Résumé

BackgroundDolosigranulum pigrum is a commensal inhabitant of the upper respiratory tract suspected to be responsible for ocular infections but no well-described case of D. pigrum corneal infection has been reported. Herein culture and PCR-sequencing-based investigations of corneal scraping specimens confirmed D. pigrum keratitis in three patients.Case presentationThree elderly patients presented with unilateral keratitis. None was a corneal-contact lens wearer, one had previous cataract surgery and another suffered rheumatoid arthritis sicca syndrome. Culturing the corneal scraping specimen was positive for two cases and PCR-sequencing of bacterial 16S rDNA in the presence of negative controls identified D. pigrum in three cases. The two D. pigrum isolates were in-vitro susceptible to penicillin G, amoxicillin, doxycycline, rifampicin and gentamicin. In all cases, surgical treatment of corneal thinning was necessary, but corneal perforation occurred in two cases despite intensive antimicrobial treatment with ticarcillin, gentamicin and vancomycin or levofloxacin eye drops leading to enucleation in one case. Conclusions D. pigrum is the likely cause of corneal infection in three patients, with effective antibiotic treatment in two patients.

Domaines

Organes des sens
Fichier principal
Vignette du fichier
1471-2415-13-31.pdf (270.71 Ko) Télécharger le fichier
1471-2415-13-31.xml (23.21 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Format : Autre
Loading...

Dates et versions

inserm-00844109 , version 1 (12-07-2013)

Identifiants

  • HAL Id : inserm-00844109 , version 1

Citer

Magali Sampo, Oaufeh Ghazouani, Dominique Cadiou, Elodie Trichet, Louis Hoffart, et al.. Dolosigranulum pigrum keratitis: a three-case series. BMC Ophthalmology, 2013, 13 (1), pp.31. ⟨inserm-00844109⟩
700 Consultations
311 Téléchargements

Partager

Gmail Facebook X LinkedIn More