Skip to Main content Skip to Navigation
Journal articles

Obesity alters the gustatory perception of lipids in the mouse: plausible involvement of lingual CD36.: Obesity decreases the fat preference

Abstract : A relationship between orosensory detection of dietary lipids, regulation of fat intake, and body mass index was recently suggested. However, involved mechanisms are poorly understood. Moreover, whether obesity can directly modulate preference for fatty foods remains unknown. To address this question, exploration of the oral lipid sensing system was undertaken in diet-induced obese (DIO) mice. By using a combination of biochemical, physiological, and behavioral approaches, we found that i) the attraction for lipids is decreased in obese mice, ii) this behavioral change has an orosensory origin, iii) it is reversed in calorie-restricted DIO mice, revealing an inverse correlation between fat preference and adipose tissue size, iv) obesity suppresses the lipid-mediated downregulation of the lipid-sensor CD36 in circumvallate papillae, usually found during the refeeding of lean mice, and v) the CD36-dependent signaling cascade controlling the intracellular calcium levels ([Ca(2+)]i) in taste bud cells is decreased in obese mice. Therefore, obesity alters the lipid-sensing system responsible for the oral perception of dietary lipids. This phenomenon seems to take place through a CD36-mediated mechanism, leading to changes in eating behavior.
Document type :
Journal articles
Complete list of metadatas

Cited literature [25 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00844033
Contributor : Arnaud Bernard <>
Submitted on : Monday, July 7, 2014 - 4:03:14 PM
Last modification on : Monday, January 27, 2020 - 11:56:02 AM
Long-term archiving on: : Tuesday, October 7, 2014 - 10:35:58 AM

File

2013-07-05_JLR.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Michaël Chevrot, Arnaud Bernard, Déborah Ancel, Marjorie Buttet, Céline Martin, et al.. Obesity alters the gustatory perception of lipids in the mouse: plausible involvement of lingual CD36.: Obesity decreases the fat preference. Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2013, 54 (9), pp.2485-94. ⟨10.1194/jlr.M039446⟩. ⟨inserm-00844033⟩

Share

Metrics

Record views

594

Files downloads

471