Role of biomarkers in the management of antibiotic therapy: an expert panel review: I - currently available biomarkers for clinical use in acute infections - Archive ouverte HAL Access content directly
Journal Articles Annals of Intensive Care Year : 2013

Role of biomarkers in the management of antibiotic therapy: an expert panel review: I - currently available biomarkers for clinical use in acute infections

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Anne-Marie Dupuy
  • Function : Author
  • PersonId : 938433
François Philippart
  • Function : Author
  • PersonId : 919038
Yves Péan
  • Function : Author
  • PersonId : 943526
Sigismond Lasocki
  • Function : Author
  • PersonId : 943527
Yann-Eric Claessens
  • Function : Author
  • PersonId : 943209
Charles-Edouard Luyt
  • Function : Author
  • PersonId : 943529
Jean-Pierre Bedos
  • Function : Author
  • PersonId : 918762
Jérôme Pugin
  • Function : Author
  • PersonId : 943531
Rémy Gauzit
  • Function : Author
  • PersonId : 918760

Abstract

In the context of worldwide increasing antimicrobial resistance, good antimicrobial prescribing in more needed than ever; unfortunately, information available to clinicians often are insufficient to rely on. Biomarkers might provide help for decision-making and improve antibiotic management. The purpose of this expert panel review was to examine currently available literature on the potential role of biomarkers to improve antimicrobial prescribing, by answering three questions: 1) Which are the biomarkers available for this purpose?; 2) What is their potential role in the initiation of antibiotic therapy?; and 3) What is their role in the decision to stop antibiotic therapy? To answer these questions, studies reviewed were limited to recent clinical studies ( < 15 years), involving a substantial number of patients (>50) and restricted to controlled trials and meta-analyses for answering questions 2 and 3. With regard to the first question concerning routinely available biomarkers, which might be useful for antibiotic management of acute infections, these are currently limited to C-reactive protein (CRP) and procalcitonin (PCT). Other promising biomarkers that may prove useful in the near future but need to undergo more extensive clinical testing include sTREM-1, suPAR, ProADM, and Presepsin. New approaches to biomarkers of infections include point-of-care testing and genomics.
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Dates and versions

inserm-00843603 , version 1 (11-07-2013)

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  • HAL Id : inserm-00843603 , version 1

Cite

Anne-Marie Dupuy, François Philippart, Yves Péan, Sigismond Lasocki, Pierre-Emmanuel Charles, et al.. Role of biomarkers in the management of antibiotic therapy: an expert panel review: I - currently available biomarkers for clinical use in acute infections. Annals of Intensive Care, 2013, 3 (1), pp.22. ⟨inserm-00843603⟩
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