Skip to Main content Skip to Navigation
Journal articles

Cell penetration properties of a highly efficient mini maurocalcine peptide

Abstract : Maurocalcine is a highly potent cell-penetrating peptide isolated from the Tunisian scorpion Maurus palmatus. Many cell-penetrating peptide analogues have been derived from the full-length maurocalcine by internal cysteine substitutions and sequence truncation. Herein we have further characterized the cell-penetrating properties of one such peptide, MCaUF1-9, whose sequence matches that of the hydrophobic face of maurocalcine. This peptide shows very favorable cell-penetration efficacy compared to Tat, penetratin or polyarginine. The peptide appears so specialized in cell penetration that it seems hard to improve bydirected mutagenesis. A comparative analysis of the efficacies of similar peptides isolated from other toxin members of the same family leads to the identification of hadrucalcin's hydrophobic face as an even better CPP. Protonation of the histidine residue at position 6 renders the cell penetration of MCaUF1-9 pH-sensitive. Greater cell penetration at acidic pH suggests that MCaUF1-9 can be used to specifically target cancer cells in vivo where tumor masses grow in more acidic environments.
Complete list of metadata

Cited literature [4 references]  Display  Hide  Download
Contributor : Marco Canepari Connect in order to contact the contributor
Submitted on : Tuesday, July 9, 2013 - 6:17:20 PM
Last modification on : Tuesday, October 19, 2021 - 10:59:23 PM
Long-term archiving on: : Wednesday, April 5, 2017 - 9:17:20 AM


Files produced by the author(s)




Céline Tisseyre, Eloi Bahembera, Lucie Dardevet, Jean-Marc Sabatier, Michel Ronjat, et al.. Cell penetration properties of a highly efficient mini maurocalcine peptide. Pharmaceuticals Policy and Law, IOS Press, 2013, 6, pp.320-339. ⟨10.3390/ph6030320⟩. ⟨inserm-00842949⟩



Record views


Files downloads