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S. Figure, ClC-2, GlialCAM and MLC1 at blood-brain and cerebrospinal fluid-brain barriers

. Fig, Schematic view of action potential-driven potassium and water fluxes With each depolarization, sodium ions (Na + ) enter the axon at nodes of Ranvier. The compensatory exit of potassium ions (K + ) occurs at the paranodal axonal plasma membrane. K + and water pass through successive layers of myelin and enter the astrocytic syncytium via gap junctions, constituted by connexin32 (Cx32) and connexin47 (Cx47) The locations of ClC-2, MLC1, GlialCAM, the water channel aquaporin-4 (AQP4), the potassium channel Kir4.1 and the connexins are indicated by their respective symbols. Drawing by Dr. G.C. Scheper, modified from Rash 10 and van der Knaap 11 with permission, p.25

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