Change in proportional protein intake in a 10-week energy-restricted low- or high-fat diet, in relation to changes in body size and metabolic factors.

Tanja Stocks; Moira Taylor; Lars Angquist; Ian Macdonald; Peter Arner; Claus Holst; Jean-Michel Oppert; J Alfredo Martinez; Stephan Rössner; Jan Polak; Dominique Langin; Wim Saris; Arne Astrup; Thorkild Sørensen

doi:10.1159/000351726

Journal articles

Change in proportional protein intake in a 10-week energy-restricted low- or high-fat diet, in relation to changes in body size and metabolic factors.

Tanja Stocks ^{1, 2, *} Moira Taylor ³ Lars Angquist ¹ Ian Macdonald ³ Peter Arner ⁴ Claus Holst ¹ Jean-Michel Oppert ⁵ J Alfredo Martinez ⁶ Stephan Rössner ⁷ Jan Polak ⁸ Dominique Langin ⁹ Wim Saris ¹⁰ Arne Astrup ¹¹ Thorkild Sørensen ^{1, 12}

* Corresponding author

1 Institute of Preventive Medicine

2 Department of Surgical and Perioperative Sciences, Urology and Andrology

3 School of Biomedical Sciences

4 Department of medicine [Stockholm]

5 CRNH-IDF - Centre de Recherche en Nutrition Humaine d'Ile-de-France

6 Department of Physiology and Nutrition

7 The Obesity Unit, Department of Medicine

8 Department of Sports Medicine, Centre of Preventive Medicine

9 I2MR - Institut de médecine moléculaire de Rangueil

10 Department of Human Biology, Nutrition and Toxicology

11 Department of Nutrition, Exercise and Sports [Copenhagen]

12 CBMR - Novo Nordisk Foundation Center for Basic Metabolic Research

Abstract : Objective: To investigate in a secondary analysis of a randomised trial the effects of a low-/high-fat diet and reported change from baseline in energy% from protein (prot%), in relation to changes in body size and metabolic factors. Methods: Obese adults (n = 771) were randomised to a 600 kcal energy-deficient low-fat (20-25 fat%) or high-fat (40-45 fat%) diet over 10 weeks. Dietary intake data at baseline and during the intervention were available in 585 completers. We used linear regression to calculate the combined effects of randomised group and groups of prot% change (<-2 /-2 to 2/>2) on outcomes. Results: The low-fat group with >2 prot% increase lost 1.1 kg more weight (p = 0.03) and reduced cholesterol by 0.25 mmol/l more (p = 0.003) than the high-fat group with >2 prot% decrease. These differences were 2.5-fold and 1.8-fold greater than the differences between the low-fat and high-fat groups while not considering prot% change. The high-fat group reduced plasma triglycerides more than the low-fat group, but not compared to those in the low-fat group with >2 units prot% increase (p fat-protein interaction = 0.01). Conclusions: Under energy restriction, participants on a low-fat diet who had increased the percentage energy intake from protein showed the greatest reduction in weight and cholesterol, and a triglyceride reduction equally large to that of participants on a high-fat diet. Copyright © 2013 S. Karger GmbH, Freiburg.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Human health and pathology / Endocrinology and metabolism

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https://www.hal.inserm.fr/inserm-00841212
Contributor : Marie Francoise Simon <>
Submitted on : Thursday, July 4, 2013 - 10:53:06 AM
Last modification on : Wednesday, August 19, 2020 - 11:16:56 AM

Change in proportional protein intake in a 10-week energy-restricted low- or high-fat diet, in relation to changes in body size and metabolic factors.

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Change in proportional protein intake in a 10-week energy-restricted low- or high-fat diet, in relation to changes in body size and metabolic factors.

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