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Journal articles
A Molecular Predictor Reassesses Classification of Human Grade II/III Gliomas.
Thierry Rème
1, *
Jean-Philippe Hugnot
2, 3
Ivan Bièche
4
Valérie Rigau
5
Fanny Burel-Vandenbos
6
Vincent Prévot
7
Marc Baroncini
7, 8
Denys Fontaine
9
Hugues Chevassus
10
Sophie Vacher
4
Rosette Lidereau
4
Hugues Duffau
2, 11
Luc Bauchet
2, 11
Dominique Joubert
12
*
Corresponding author
Thierry Rème 1
Mail :
Correspondent author
Jean-Philippe Hugnot 2, 3
Author
Ivan Bièche 4
Author
Valérie Rigau 5
Author
Fanny Burel-Vandenbos 6
Author
Vincent Prévot 7
Author
Marc Baroncini 7, 8
Author
Denys Fontaine 9
Author
Hugues Chevassus 10
Author
Sophie Vacher 4
Author
Rosette Lidereau 4
Author
Hugues Duffau 2, 11
Author
Luc Bauchet 2, 11
Author
Dominique Joubert 12
Author
1
Cellules souches normales et cancéreuses (Hôpital Saint-Eloi, 80 av Augustin Fliche 34295 Montpellier Cedex 15 - France)
- UM1 - Université Montpellier 1 (5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1040 (101, rue de Tolbiac, 75013 Paris - France)
- UM - Université de Montpellier (163 rue Auguste Broussonnet - 34090 Montpellier - France)
2
INM - Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (Hôpital Saint Eloi - Bâtiment INM - 80, rue Augustin Fliche - BP 74103 - 34091 Montpellier cedex 5 - France)
- UM - Université de Montpellier (163 rue Auguste Broussonnet - 34090 Montpellier - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U 1051 (101, rue de Tolbiac, 75013 Paris - France)
3
UM2 - Université Montpellier 2 - Sciences et Techniques (Place Eugène Bataillon - 34095 Montpellier cedex 5 - France)
4
Oncogénétique (Saint-Cloud - France)
- Institut Curie ( 26 rue d'Ulm - 75248 Paris Cedex 05 - France - France)
- Hôpital René HUGUENIN (Saint-Cloud) ( 35, rue Dailly 92210 Saint-Cloud - France)
5
Département de pathologie et biobanque (Montpellier - France)
- CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier] (191 avenue du doyen Gaston Giraud 34295 Montpellier cedex 5 - France)
6
Service de pathologie (Nice - France)
- CHU Nice - Centre Hospitalier Universitaire de Nice (30, Voie Romaine CS 51069 - 06001 Nice Cedex 1 - France)
7
JPArc - U837 Inserm - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (Faculté de Médecine - Pôle Recherche - 1 place de verdun 59045 Lille cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U837 (101, rue de Tolbiac, 75013 Paris - France)
- Université Lille 2 - Faculté de Médecine (1, place de Verdun 59045 Lille Cédex - France)
- CHRU Lille - Centre Hospitalier Régional Universitaire [Lille] (2, avenue Oscar Lambret - 59037 Lille Cedex - France)
8
Service de neurochirurgie (Lille - France)
- CHRU Lille - Centre Hospitalier Régional Universitaire [Lille] (2, avenue Oscar Lambret - 59037 Lille Cedex - France)
9
Service de Neurochirurgie (France)
- CHU Nice - Centre Hospitalier Universitaire de Nice (30, Voie Romaine CS 51069 - 06001 Nice Cedex 1 - France)
10
CIC - Montpellier (Hopital Saint-Eloi MONTPELLIER 80, Avenue Augustin Fliche 34295 MONTPELLIER CEDEX 5 - France)
- UM1 - Université Montpellier 1 (5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : CIC1 (101, rue de Tolbiac, 75013 Paris - France)
11
Service de neurochirurgie (Montpellier - France)
- CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier] (191 avenue du doyen Gaston Giraud 34295 Montpellier cedex 5 - France)
12
IGF - Institut de Génomique Fonctionnelle (141, Rue de la Cardonille 34094 Montpellier cedex 5 - France)
- UM - Université de Montpellier (163 rue Auguste Broussonnet - 34090 Montpellier - France)
- UM1 - Université Montpellier 1 (5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1191 (101, rue de Tolbiac, 75013 Paris - France)
- UM2 - Université Montpellier 2 - Sciences et Techniques (Place Eugène Bataillon - 34095 Montpellier cedex 5 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5203 (France)
Abstract : Diffuse gliomas are incurable brain tumors divided in 3 WHO grades (II; III; IV) based on histological criteria. Grade II/III gliomas are clinically very heterogeneous and their prognosis somewhat unpredictable, preventing definition of appropriate treatment. On a cohort of 65 grade II/III glioma patients, a QPCR-based approach allowed selection of a biologically relevant gene list from which a gene signature significantly correlated to overall survival was extracted. This signature clustered the training cohort into two classes of low and high risk of progression and death, and similarly clustered two external independent test cohorts of 104 and 73 grade II/III patients. A 22-gene class predictor of the training clusters optimally distinguished poor from good prognosis patients (median survival of 13-20 months versus over 6 years) in the validation cohorts. This classification was stronger at predicting outcome than the WHO grade II/III classification (P≤2.8E-10 versus 0.018). When compared to other prognosis factors (histological subtype and genetic abnormalities) in a multivariate analysis, the 22-gene predictor remained significantly associated with overall survival. Early prediction of high risk patients (3% of WHO grade II), and low risk patients (29% of WHO grade III) in clinical routine will allow the development of more appropriate follow-up and treatments.
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https://www.hal.inserm.fr/inserm-00840252
Contributor : Monique Frei <>
Submitted on : Tuesday, July 2, 2013 - 9:20:20 AM
Last modification on : Friday, May 15, 2020 - 12:22:05 PM
Document(s) archivé(s) le : Wednesday, April 5, 2017 - 5:44:14 AM
Contributor : Monique Frei <>
Submitted on : Tuesday, July 2, 2013 - 9:20:20 AM
Last modification on : Friday, May 15, 2020 - 12:22:05 PM
Document(s) archivé(s) le : Wednesday, April 5, 2017 - 5:44:14 AM
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journal_pone_0066574.pdf
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Identifiers
- HAL Id : inserm-00840252, version 1
- DOI : 10.1371/journal.pone.0066574
- PUBMED : 23805239
Collections
CNRS | FNCLCC | CURIE | PSL | BS | UNIV-MONTPELLIER | UNIV-COTEDAZUR
Citation
Thierry Rème, Jean-Philippe Hugnot, Ivan Bièche, Valérie Rigau, Fanny Burel-Vandenbos, et al.. A Molecular Predictor Reassesses Classification of Human Grade II/III Gliomas.. PLoS ONE, Public Library of Science, 2013, 8 (6), pp.e66574. ⟨10.1371/journal.pone.0066574⟩. ⟨inserm-00840252⟩
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