A Molecular Predictor Reassesses Classification of Human Grade II/III Gliomas.

Abstract : Diffuse gliomas are incurable brain tumors divided in 3 WHO grades (II; III; IV) based on histological criteria. Grade II/III gliomas are clinically very heterogeneous and their prognosis somewhat unpredictable, preventing definition of appropriate treatment. On a cohort of 65 grade II/III glioma patients, a QPCR-based approach allowed selection of a biologically relevant gene list from which a gene signature significantly correlated to overall survival was extracted. This signature clustered the training cohort into two classes of low and high risk of progression and death, and similarly clustered two external independent test cohorts of 104 and 73 grade II/III patients. A 22-gene class predictor of the training clusters optimally distinguished poor from good prognosis patients (median survival of 13-20 months versus over 6 years) in the validation cohorts. This classification was stronger at predicting outcome than the WHO grade II/III classification (P≤2.8E-10 versus 0.018). When compared to other prognosis factors (histological subtype and genetic abnormalities) in a multivariate analysis, the 22-gene predictor remained significantly associated with overall survival. Early prediction of high risk patients (3% of WHO grade II), and low risk patients (29% of WHO grade III) in clinical routine will allow the development of more appropriate follow-up and treatments.
Type de document :
Article dans une revue
PLoS ONE, Public Library of Science, 2013, 8 (6), pp.e66574. 〈10.1371/journal.pone.0066574〉
Liste complète des métadonnées

Littérature citée [63 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00840252
Contributeur : Monique Frei <>
Soumis le : mardi 2 juillet 2013 - 09:20:20
Dernière modification le : vendredi 27 juillet 2018 - 15:34:07
Document(s) archivé(s) le : mercredi 5 avril 2017 - 05:44:14

Fichier

journal_pone_0066574.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Citation

Thierry Rème, Jean-Philippe Hugnot, Ivan Bièche, Valérie Rigau, Fanny Burel-Vandenbos, et al.. A Molecular Predictor Reassesses Classification of Human Grade II/III Gliomas.. PLoS ONE, Public Library of Science, 2013, 8 (6), pp.e66574. 〈10.1371/journal.pone.0066574〉. 〈inserm-00840252〉

Partager

Métriques

Consultations de la notice

699

Téléchargements de fichiers

225