Organization of brain networks governed by long-range connections index autistic traits in the general population.

Pablo Barttfeld 1, 2 Lucía Amoruso 3 Joaquín Ais 2 Sebastián Cukier 2, 4 Luz Bavassi 2 Ailin Tomio 3 Facundo Manes 3 Agustín Ibanez 3, 5, * Mariano Sigman 2, 6
* Auteur correspondant
1 UNICOG-U992 - Neuroimagerie cognitive
2 Laboratory of Integrative Neuroscience
3 INECO - Institute of Cognitive Neurology
4 PANAACEA - Programa Argentino para Niños, Adolescentes y Adultos con Condiciones del Espectro Autista
5 UIFCoN - UDP-INECO Foundation Core on Neuroscience
6 Ciencias Cognitivas
Abstract : BACKGROUND: The dimensional approach to autism spectrum disorder (ASD) considers ASD as the extreme of a dimension traversing through the entire population. We explored the potential utility of electroencephalography (EEG) functional connectivity as a biomarker. We hypothesized that individual differences in autistic traits of typical subjects would involve a long-range connectivity diminution within the delta band. METHODS: Resting-state EEG functional connectivity was measured for 74 neurotypical subjects. All participants also provided a questionnaire (Social Responsiveness Scale, SRS) that was completed by an informant who knows the participant in social settings. We conducted multivariate regression between the SRS score and functional connectivity in all EEG frequency bands. We explored modulations of network graph metrics characterizing the optimality of a network using the SRS score. RESULTS: Our results show a decay in functional connectivity mainly within the delta and theta bands (the lower part of the EEG spectrum) associated with an increasing number of autistic traits. When inspecting the impact of autistic traits on the global organization of the functional network, we found that the optimal properties of the network are inversely related to the number of autistic traits, suggesting that the autistic dimension, throughout the entire population, modulates the efficiency of functional brain networks. CONCLUSIONS: EEG functional connectivity at low frequencies and its associated network properties may be associated with some autistic traits in the general population.
Keywords : Autism spectrum disorders Electroencephalography Autistic traits Synchronization likelihood Small world Long-range connections
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Article dans une revue
Journal of Neurodevelopmental Disorders, BioMed Central, 2013, 5 (1), pp.16. 〈10.1186/1866-1955-5-16〉
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Soumis le : lundi 1 juillet 2013 - 13:09:24
Dernière modification le : mardi 5 juin 2018 - 01:12:09
Document(s) archivé(s) le : mercredi 2 octobre 2013 - 04:12:33

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Pablo Barttfeld, Lucía Amoruso, Joaquín Ais, Sebastián Cukier, Luz Bavassi, et al.. Organization of brain networks governed by long-range connections index autistic traits in the general population.. Journal of Neurodevelopmental Disorders, BioMed Central, 2013, 5 (1), pp.16. 〈10.1186/1866-1955-5-16〉. 〈inserm-00839998〉

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