Skip to Main content Skip to Navigation
Journal articles

Mitochondria and endoplasmic reticulum: mitochondria-endoplasmic reticulum interplay in type 2 diabetes pathophysiology.

Abstract : Mitochondria and endoplasmic reticulum (ER) are two important metabolic organelles for the maintenance of cellular homeostasis and their functional defects are suspected to participate to the aetiology of type 2 diabetes (T2D). Particularly, excessive lipid intake and/or ectopic lipid accumulation in tissues (referred as lipotoxicity) are involved in alterations of both organelles and are closely linked to peripheral insulin resistance and defective insulin secretion. Since, mitochondria and ER are physically and functionally interconnected, their respective alterations during T2D could be interrelated. However, the mechanisms that coordinate the interplay between mitochondrial dysfunction and ER stress, and its relevance in the control of glucose homeostasis are unknown. Among these mechanisms, we will discuss on the potential role of altered mitochondria/ER crosstalk in organelle dysfunctions and in T2D pathophysiology.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00839452
Contributor : Evelyne Vericel <>
Submitted on : Saturday, June 29, 2013 - 7:00:18 AM
Last modification on : Wednesday, July 8, 2020 - 12:42:52 PM

File

Revue_RIEUSSET.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Jennifer Rieusset. Mitochondria and endoplasmic reticulum: mitochondria-endoplasmic reticulum interplay in type 2 diabetes pathophysiology.. International Journal of Biochemistry and Cell Biology, Elsevier, 2011, 43 (9), pp.1257-62. ⟨10.1016/j.biocel.2011.05.006⟩. ⟨inserm-00839452⟩

Share

Metrics

Record views

1189

Files downloads

528