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The transcriptomic response of mixed neuron-glial cell cultures to 1,25-dihydroxyvitamin d3 includes genes limiting the progression of neurodegenerative diseases.

Marie-France Nissou 1 Jacques Brocard 2 Michèle El Atifi 1 Audrey Guttin 1 Annie Andrieux 3 François Berger 1 Jean-Paul Issartel 1 Didier Wion 1, *
* Corresponding author
1 Inserm U836, équipe 7, Nanomédecine et cerveau
GIN - Grenoble Institut des Neurosciences
2 INSERM U836, équipe 1, Physiopathologie du cytosquelette
GIN - Grenoble Institut des Neurosciences
3 INSERM U836, équipe 1, Physiopathologie du cytosquelette
GPC - Groupe Physiopathologie du Cytosquelette, GIN - Grenoble Institut des Neurosciences
Abstract : Seasonal or chronic vitamin D deficiency and/or insufficiency is highly prevalent in the human population. Receptors for 1,25-dihydroxyvitamin D3, the hormonal metabolite of vitamin D, are found throughout the brain. To provide further information on the role of this hormone on brain function, we analyzed the transcriptomic profiles of mixed neuron-glial cell cultures in response to 1,25-dihydroxyvitamin D3. 1,25-dihydroxyvitamin D3 treatment increases the mRNA levels of 27 genes by at least 1.9 fold. Among them, 17 genes were related to neurodegenerative and psychiatric diseases, or brain morphogenesis. Notably, 10 of these genes encode proteins potentially limiting the progression of Alzheimer's disease. These data provide support for a role of 1,25-dihydroxyvitamin D3 in brain disease prevention. The possible consequences of circannual or chronic vitamin D insufficiencies on a tissue with a low regenerative potential such as the brain should be considered.
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https://www.hal.inserm.fr/inserm-00838410
Contributor : Jean-Paul Issartel <>
Submitted on : Tuesday, June 25, 2013 - 3:32:03 PM
Last modification on : Thursday, March 26, 2020 - 6:57:38 PM
Long-term archiving on: : Thursday, September 26, 2013 - 4:20:05 AM

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Marie-France Nissou, Jacques Brocard, Michèle El Atifi, Audrey Guttin, Annie Andrieux, et al.. The transcriptomic response of mixed neuron-glial cell cultures to 1,25-dihydroxyvitamin d3 includes genes limiting the progression of neurodegenerative diseases.. Journal of Alzheimer's Disease, IOS Press, 2013, 35 (3), pp.553-64. ⟨10.3233/JAD-122005⟩. ⟨inserm-00838410⟩

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