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SERT radiolabeling expressed as % of control-treated WT respective values for 4-5 mice per genotype and per treatment Coronal levels: LC, locus coeruleus (IA = -1.72 to -1.54); Ra, raphe (IA = -0.80 to -0.40) ,
See abbreviations in Table S6. Three-way ANOVA followed by Student's t test: * p < 0.050; *** p < 0.001, comparison between genotypes; ns, not significant, comparison between treatments, +22% ns -60% *** -69% ns -70% ns Vis Cx -7% ns +13 % ns -64% *** -68% ns -70% ns Hipp -21% ns +2% ns -57% *** -57% ns -64% ns SN -18% ns +2% ns -2% ns -16% ns -3% ns VTA -18% ns +2% ns +21% *** +8% ns +26% ns MEnt Cx -6% ns -4% ns -67% *** -66% ns -67% ns, 1997. ,
NET radiolabeling expressed as % of control-treated WT respective values for 4-5 mice per genotype and per treatment, Coronal levels: LC, locus coeruleus ,
IA = -0.80 to -0.40); SN, substantia nigra (IA = -0.08 to 0 ,
IA = 1.98 to 2.74); Str, striatum (IA = 4.78 to 5.34) according to Franklin & Paxinos See abbreviations in Table S6. Three-way ANOVA followed by Student's t test: ns non significant, comparison between genotypes; ns, not significant, comparison between treatments, 1997. ,
Coat state Score 58d 16.8±0.3 10, Table S5 Performances of WT and STOP KO males after various treatments Parameter Basal Acute stress Chronic stress Chronic2±0.9* 8.3±1.9$ 8.4±1.4 19.6±0.2$# 12.4±2.0*# Splash test Latency 38.0±6.3 122±16 ,
WT and STOP KO males in basal condition (Fournet et al. 2012 and this study), 9-12 WT and STOP KO males after acute stress, 9-10 WT and STOP KO males after chronic stress and fluoxetine treatment (mice of both genotypes in equal proportion for each test). (a) number at 20 min; L, light box. Two-way ANOVA followed by post hoc Fisher's tests: * p < 0.05, comparison between genotypes ,