Epithelial to mesenchymal transition-The roles of cell morphology, labile adhesion and junctional coupling.

Tariq Abdulla 1, * Jean-Marc Schleich 2 Ron Summers 1
* Auteur correspondant
1 Research School of Systems Engineering
2 LTSI - Laboratoire Traitement du Signal et de l'Image
Abstract : Epithelial to mesenchymal transition (EMT) is a fundamental process during development and disease, including development of the heart valves and tumour metastases. An extended cellular Potts model was implemented to represent the behaviour emerging from autonomous cell morphology, labile adhesion, junctional coupling and cell motility. Computer simulations normally focus on these functional changes independently whereas this model facilitates exploration of the interplay between cell shape changes, adhesion and migration. The simulation model is fitted to an in vitro model of endocardial EMT, and agrees with the finding that Notch signalling increases cell-matrix adhesion in addition to modulating cell-cell adhesion.
Keywords : Modelling Development Notch Motility Plasticity Cadherin
Type de document :
Article dans une revue
Computer Methods and Programs in Biomedicine, Elsevier, 2013, 111 (2), pp.435-446. 〈10.1016/j.cmpb.2013.05.018〉
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Tariq Abdulla, Jean-Marc Schleich, Ron Summers. Epithelial to mesenchymal transition-The roles of cell morphology, labile adhesion and junctional coupling.. Computer Methods and Programs in Biomedicine, Elsevier, 2013, 111 (2), pp.435-446. 〈10.1016/j.cmpb.2013.05.018〉. 〈inserm-00838163〉

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