Epithelial to mesenchymal transition-The roles of cell morphology, labile adhesion and junctional coupling. - Archive ouverte HAL Access content directly
Journal Articles Computer Methods and Programs in Biomedicine Year : 2013

Epithelial to mesenchymal transition-The roles of cell morphology, labile adhesion and junctional coupling.

(1) , (2) , (1)
1
2

Abstract

Epithelial to mesenchymal transition (EMT) is a fundamental process during development and disease, including development of the heart valves and tumour metastases. An extended cellular Potts model was implemented to represent the behaviour emerging from autonomous cell morphology, labile adhesion, junctional coupling and cell motility. Computer simulations normally focus on these functional changes independently whereas this model facilitates exploration of the interplay between cell shape changes, adhesion and migration. The simulation model is fitted to an in vitro model of endocardial EMT, and agrees with the finding that Notch signalling increases cell-matrix adhesion in addition to modulating cell-cell adhesion.
Fichier principal
Vignette du fichier
Abdulla_CMPB_Mar2013.pdf (2.03 Mo) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-00838163 , version 1 (24-06-2013)

Identifiers

Cite

Tariq Abdulla, Jean-Marc Schleich, Ron Summers. Epithelial to mesenchymal transition-The roles of cell morphology, labile adhesion and junctional coupling.. Computer Methods and Programs in Biomedicine, 2013, 111 (2), pp.435-446. ⟨10.1016/j.cmpb.2013.05.018⟩. ⟨inserm-00838163⟩
340 View
663 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More