Skip to Main content Skip to Navigation
Journal articles

Epithelial to mesenchymal transition-The roles of cell morphology, labile adhesion and junctional coupling.

Abstract : Epithelial to mesenchymal transition (EMT) is a fundamental process during development and disease, including development of the heart valves and tumour metastases. An extended cellular Potts model was implemented to represent the behaviour emerging from autonomous cell morphology, labile adhesion, junctional coupling and cell motility. Computer simulations normally focus on these functional changes independently whereas this model facilitates exploration of the interplay between cell shape changes, adhesion and migration. The simulation model is fitted to an in vitro model of endocardial EMT, and agrees with the finding that Notch signalling increases cell-matrix adhesion in addition to modulating cell-cell adhesion.
Complete list of metadatas

Cited literature [22 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00838163
Contributor : Lotfi Senhadji <>
Submitted on : Monday, June 24, 2013 - 8:36:43 PM
Last modification on : Thursday, July 26, 2018 - 1:56:20 PM
Long-term archiving on: : Wednesday, September 25, 2013 - 4:12:07 AM

File

Abdulla_CMPB_Mar2013.pdf
Files produced by the author(s)

Identifiers

Citation

Tariq Abdulla, Jean-Marc Schleich, Ron Summers. Epithelial to mesenchymal transition-The roles of cell morphology, labile adhesion and junctional coupling.. Computer Methods and Programs in Biomedicine, Elsevier, 2013, 111 (2), pp.435-446. ⟨10.1016/j.cmpb.2013.05.018⟩. ⟨inserm-00838163⟩

Share

Metrics

Record views

744

Files downloads

800