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Journal articles
Analysis of electrode deformations in deep brain stimulation surgery.
Abstract : PURPOSE : Deep brain stimulation (DBS) surgery is used to reduce motor symptoms when movement disorders are refractory to medical treatment. Post-operative brain morphology can induce electrode deformations as the brain recovers from an intervention. The inverse brain shift has a direct impact on accuracy of the targeting stage, so analysis of electrode deformations is needed to predict final positions. METHODS: DBS electrode curvature was evaluated in 76 adults with movement disorders who underwent bilateral stimulation, and the key variables that affect electrode deformations were identified. Non-linear modelling of the electrode axis was performed using post-operative computed tomography (CT) images. A mean curvature index was estimated for each patient electrode. Multivariate analysis was performed using a regression decision tree to create a hierarchy of predictive variables. The identification and classification of key variables that determine electrode curvature were validated with statistical analysis. RESULTS: The principal variables affecting electrode deformations were found to be the date of the post-operative CT scan and the stimulation target location. The main pathology, patient's gender, and disease duration had a smaller although important impact on brain shift. CONCLUSIONS: The principal determinants of electrode location accuracy during DBS procedures were identified and validated. These results may be useful for improved electrode targeting with the help of mathematical models.
Cited literature [39 references]
https://www.hal.inserm.fr/inserm-00836932
Contributor : Florent Lalys <>
Submitted on : Friday, June 21, 2013 - 5:44:21 PM
Last modification on : Thursday, January 14, 2021 - 11:16:49 AM
Long-term archiving on: : Sunday, September 22, 2013 - 4:11:28 AM
Contributor : Florent Lalys <>
Submitted on : Friday, June 21, 2013 - 5:44:21 PM
Last modification on : Thursday, January 14, 2021 - 11:16:49 AM
Long-term archiving on: : Sunday, September 22, 2013 - 4:11:28 AM
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Courbure-DBS-V9.pdf
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