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Mechanism of one-electron oxidation of metformin in aqueous solution.

Abstract : Hydroxyl free radical-induced oxidation of metformin was studied in aqueous solution as a function of the pH. Hydroxyl free radicals were generated by gamma radiolysis of water and the oxidation end-products were quantified by high-performance liquid chromatography coupled to mass spectrometry (HPLC/MS), as a function of the radiation dose. This work is a joint experimental and theoretical (DFT) approach that has paved the way towards a comprehensive rationalization of the one-electron mechanisms of MTF oxidation, as a function of the pH.
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Submitted on : Tuesday, May 6, 2014 - 11:54:55 AM
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Patrick Trouillas, Catherine Marchetti, Dominique Bonnefont-Rousselot, Roberto Lazzaroni, Daniel Jore, et al.. Mechanism of one-electron oxidation of metformin in aqueous solution.. Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2013, 15 (24), pp.9871-8. ⟨10.1039/c3cp50602a⟩. ⟨inserm-00835596⟩



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