Skip to Main content Skip to Navigation
Journal articles

Mechanism of one-electron oxidation of metformin in aqueous solution.

Abstract : Hydroxyl free radical-induced oxidation of metformin was studied in aqueous solution as a function of the pH. Hydroxyl free radicals were generated by gamma radiolysis of water and the oxidation end-products were quantified by high-performance liquid chromatography coupled to mass spectrometry (HPLC/MS), as a function of the radiation dose. This work is a joint experimental and theoretical (DFT) approach that has paved the way towards a comprehensive rationalization of the one-electron mechanisms of MTF oxidation, as a function of the pH.
Document type :
Journal articles
Complete list of metadatas

Cited literature [19 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00835596
Contributor : Pierre Marquet <>
Submitted on : Tuesday, May 6, 2014 - 11:54:55 AM
Last modification on : Wednesday, October 21, 2020 - 6:14:05 PM
Long-term archiving on: : Wednesday, August 6, 2014 - 10:45:35 AM

File

PCCP2013.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Patrick Trouillas, Catherine Marchetti, Dominique Bonnefont-Rousselot, Roberto Lazzaroni, Daniel Jore, et al.. Mechanism of one-electron oxidation of metformin in aqueous solution.. Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2013, 15 (24), pp.9871-8. ⟨10.1039/c3cp50602a⟩. ⟨inserm-00835596⟩

Share

Metrics

Record views

836

Files downloads

2109