Single spin-echo T2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain.

Lijing Xin; Giulio Gambarota; Cristina Cudalbu; Vladimír Mlynárik; Rolf Gruetter

doi:10.1007/s10334-013-0378-3

Single spin-echo T2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain.: T2 Relaxation Times of Cerebral Metabolites at 14.1 T

Lijing Xin ^{1, 2, *} Giulio Gambarota ³ Cristina Cudalbu ² Vladimír Mlynárik ² Rolf Gruetter ^{1, 4}

* Auteur correspondant

1 Departments of Radiology

2 EPFL - Ecole Polytechnique Fédérale de Lausanne

3 LTSI - Laboratoire Traitement du Signal et de l'Image

4 Departments of Radiology

Abstract : OBJECT: To determine the single spin-echo T2 relaxation times of uncoupled and J-coupled metabolites in rat brain in vivo at 14.1 T and to compare these results with those previously obtained at 9.4 T. MATERIALS AND METHODS: Measurements were performed on five rats at 14.1 T using the SPECIAL sequence and TE-specific basis-sets for LCModel analysis. RESULTS AND CONCLUSION: The T2 of singlets ranged from 98 to 148 ms and T2 of J-coupled metabolites ranged from 72 ms (glutamate) to 97 ms (myo-inositol). When comparing the T2s of the metabolites measured at 14.1 T with those previously measured at 9.4 T, a decreasing trend was found (p<0.0001). We conclude that the modest shortening of T2 at 14.1 T has a negligible impact on the sensitivity of the 1H MRS when performed at TE shorter than 10 ms.

Keywords : T2 relaxation time coupled spin systems brain metabolites proton magnetic resonance localized spectroscopy

Type de document :

Article dans une revue

Magnetic Resonance Materials in Physics, Biology and Medicine, Springer Verlag, 2013, 26 (6), pp.549-54. 〈10.1007/s10334-013-0378-3〉

Domaine :

Sciences du Vivant [q-bio] / Ingénierie biomédicale

Sciences de l'ingénieur [physics] / Traitement du signal et de l'image

Informatique [cs] / Traitement du signal et de l'image

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Single spin-echo T2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain.: T2 Relaxation Times of Cerebral Metabolites at 14.1 T

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