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An Emerging Role for PI5P in T Cell Biology.

Abstract : Phosphoinositides are critical regulators in cell biology. Phosphatidylinositol 4,5-bisphosphate, also known as PI(4,5)P2 or PIP2, was the first variety of phosphoinositide to enter in the T cell signaling scene. Phosphatidylinositol bis-phosphates are the substrates for different types of enzymes such as phospholipases C (β and γ isoforms) and phosphoinositide 3-kinases (PI3K class IA and IB) that are largely involved in signal transduction. However until recently, only a few studies highlighted phosphatidylinositol monophosphates as signaling molecules. This was mostly due to the difficulty of detection of some of these phosphoinositides, such as phosphatidylinositol 5-phosphate, also known as PI5P. Some compelling evidence argues for a role of PI5P in cell signaling and/or cell trafficking. Recently, we reported the detection of a PI5P increase upon TCR triggering. Here, we describe the current knowledge of the role of PI5P in T cell signaling. The future challenges that will be important to achieve in order to fully characterize the role of PI5P in T cell biology, will be discussed.
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https://www.hal.inserm.fr/inserm-00828688
Contributor : Jacques Nunès <>
Submitted on : Friday, May 31, 2013 - 2:47:26 PM
Last modification on : Friday, October 23, 2020 - 4:53:42 PM
Long-term archiving on: : Tuesday, April 4, 2017 - 2:43:42 PM

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Jacques Nunès, Geoffrey Guittard. An Emerging Role for PI5P in T Cell Biology.. Frontiers in Immunology, Frontiers, 2013, 4, pp.80. ⟨10.3389/fimmu.2013.00080⟩. ⟨inserm-00828688⟩

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