P. Hollingworth, D. Harold, R. Sims, A. Gerrish, J. Lambert et al., Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease, Nature Genetics, vol.41, issue.5, pp.429-464, 2011.
DOI : 10.1038/ng.2007.16

S. Seshadri, A. Fitzpatrick, M. Ikram, A. Destefano, V. Gudnason et al., Genomewide analysis of genetic loci associated with Alzheimer disease, Jama, vol.3033, pp.1832-1872, 2010.

D. Altshuler, M. Daly, and E. Lander, Genetic Mapping in Human Disease, Science, vol.322, issue.5903, pp.881-889, 2008.
DOI : 10.1126/science.1156409

L. Fratiglioni, L. Launer, K. Andersen, M. Breteler, J. Copeland et al., Incidence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group, Neurology, vol.54, pp.10-15, 2000.

M. Osterlund and Y. Hurd, Estrogen receptors in the human forebrain and the relation to neuropsychiatric disorders, Progress in Neurobiology, vol.64, issue.3, pp.251-67, 2001.
DOI : 10.1016/S0301-0082(00)00059-9

J. Spencer, E. Waters, R. Romeo, G. Wood, T. Milner et al., Uncovering the mechanisms of estrogen effects on hippocampal function, Frontiers in Neuroendocrinology, vol.29, issue.2, pp.219-256, 2008.
DOI : 10.1016/j.yfrne.2007.08.006

J. Ryan, J. Scali, I. Carriere, K. Ritchie, and M. Ancelin, Hormonal treatment, mild cognitive impairment and Alzheimer's disease, International Psychogeriatrics, vol.273, issue.01, pp.47-56, 2008.
DOI : 10.1097/00002093-200304000-00002

M. Brandi, L. Becherini, L. Gennari, M. Racchi, A. Bianchetti et al., Association of the Estrogen Receptor ?? Gene Polymorphisms with Sporadic Alzheimer's Disease, Biochemical and Biophysical Research Communications, vol.265, issue.2, pp.335-343, 1999.
DOI : 10.1006/bbrc.1999.1665

R. Corbo, G. Gambina, M. Ruggeri, and R. Scacchi, Association of Estrogen Receptor ?? (ESR1) <i>Pvu</i>II and <i>Xba</i>I Polymorphisms with Sporadic Alzheimer???s Disease and Their Effect on Apolipoprotein E Concentrations, Dementia and Geriatric Cognitive Disorders, vol.22, issue.1, pp.67-72, 2006.
DOI : 10.1159/000093315

K. Isoe-wada, M. Maeda, J. Yong, Y. Adachi, H. Harada et al., Positive association between an estrogen receptor gene polymorphism and Parkinson's disease with dementia, European Journal of Neurology, vol.42, issue.1, pp.431-436, 1999.
DOI : 10.1016/S0006-8993(97)00330-2

Y. Ji, K. Urakami, K. Wada-isoe, Y. Adachi, and K. Nakashima, Estrogen Receptor Gene Polymorphisms in Patients with Alzheimer???s Disease, Vascular Dementia and Alcohol-Associated Dementia, Dementia and Geriatric Cognitive Disorders, vol.11, issue.3, pp.119-141, 2000.
DOI : 10.1159/000017224

O. Combarros, J. Riancho, J. Arozamena, I. Mateo, J. Llorca et al., Interaction between estrogen receptor-?? and butyrylcholinesterase genes modulates Alzheimer???s disease risk, Journal of Neurology, vol.13, issue.9, pp.1290-1292, 2007.
DOI : 10.1007/s00415-006-0502-7

V. Giedraitis, L. Kilander, M. Degerman-gunnarsson, J. Sundelof, T. Axelsson et al., Genetic Analysis of Alzheimer???s Disease in the Uppsala Longitudinal Study of Adult Men, Dementia and Geriatric Cognitive Disorders, vol.27, issue.1, pp.59-68, 2009.
DOI : 10.1159/000191203

H. Maruyama, H. Toji, C. Harrington, K. Sasaki, Y. Izumi et al., Lack of an Association of Estrogen Receptor ?? Gene Polymorphisms and Transcriptional Activity With Alzheimer Disease, Archives of Neurology, vol.57, issue.2, pp.236-276, 2000.
DOI : 10.1001/archneur.57.2.236

R. Monastero, A. Cefalu, C. Camarda, D. Noto, L. Camarda et al., Association of estrogen receptor ?? gene with Alzheimer's disease: A case-control study, Journal of Alzheimer's Disease, vol.9, issue.3, pp.273-281, 2006.
DOI : 10.3233/JAD-2006-9306

L. Bertram, M. Mcqueen, K. Mullin, D. Blacker, and R. Tanzi, Systematic meta-analyses of

C. Luckhaus and P. Sand, Estrogen Receptor 1 gene (ESR1) variants in Alzheimer???s disease. Results of a meta-analysis, Aging Clinical and Experimental Research, vol.41, issue.2, pp.165-173, 2007.
DOI : 10.1007/BF03324684

T. Den-heijer, S. Schuit, H. Pols, J. Van-meurs, A. Hofman et al., Variations in estrogen receptor ?? gene and risk of dementia, and brain volumes on MRI, Molecular Psychiatry, vol.9, issue.12, pp.1129-1164, 2004.
DOI : 10.1038/sj.mp.4001553

L. Wang, S. Andersson, M. Warner, and J. Gustafsson, Morphological abnormalities in the brains of estrogen receptor ?? knockout mice, Proceedings of the National Academy of Sciences, vol.98, issue.5, pp.2792-2798, 2001.
DOI : 10.1073/pnas.041617498

R. Lambert, J. Harris, J. Mann, D. Lemmon, H. Coates et al., Are the estrogen receptors involved in Alzheimer's disease?, Neuroscience Letters, vol.306, issue.3, pp.193-200, 2001.
DOI : 10.1016/S0304-3940(01)01806-7

3. The and . Group, Vascular factors and risk of dementia: Design of the three city study and baseline characteristics of the study population, Neuroepidemiology, vol.22, pp.316-325, 2003.

G. Mckhann, D. Drachman, M. Folstein, R. Katzman, D. Price et al., Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease, Neurology, vol.34, issue.7, pp.939-983, 1984.
DOI : 10.1212/WNL.34.7.939

E. Sundermann, P. Maki, and J. Bishop, A review of estrogen receptor ?? gene (ESR1) polymorphisms, mood, and cognition, Menopause, vol.17, issue.4, pp.874-86, 2010.
DOI : 10.1097/gme.0b013e3181df4a19

D. Herrington, T. Howard, K. Brosnihan, D. Mcdonnell, X. Li et al., Common Estrogen Receptor Polymorphism Augments Effects of Hormone Replacement Therapy on E-Selectin but Not C-Reactive Protein, Circulation, vol.105, issue.16, pp.1879-82, 2002.
DOI : 10.1161/01.CIR.0000016173.98826.88

P. Alonso, M. Gratacos, C. Segalas, G. Escaramis, E. Real et al., Variants in estrogen receptor alpha gene are associated with phenotypical expression of obsessive-compulsive disorder, Psychoneuroendocrinology, vol.36, issue.4, pp.473-83, 2011.
DOI : 10.1016/j.psyneuen.2010.07.022

K. Rexrode, P. Ridker, H. Hegener, J. Buring, J. Manson et al., Polymorphisms and Haplotypes of the Estrogen Receptor-?? Gene (ESR2) and Cardiovascular Disease in Men and Women, Clinical Chemistry, vol.53, issue.10, pp.1749-56, 2007.
DOI : 10.1373/clinchem.2007.091454

J. Ryan, J. Scali, I. Carriere, P. Scarabin, K. Ritchie et al., Estrogen receptor gene variants are associated with anxiety disorders in older women, Psychoneuroendocrinology, vol.36, issue.10, pp.1582-1588, 2011.
DOI : 10.1016/j.psyneuen.2011.04.011
URL : https://hal.archives-ouvertes.fr/inserm-00619147

M. Pirskanen, M. Hiltunen, A. Mannermaa, S. Helisalmi, M. Lehtovirta et al., Estrogen receptor beta gene variants are associated with increased risk of Alzheimer's disease in women, European Journal of Human Genetics, vol.322, issue.9
DOI : 10.1038/sj.ejhg.5201447

L. Radloff, The CES-D Scale: A Self-Report Depression Scale for Research in the General Population, Applied Psychological Measurement, vol.1, issue.3
DOI : 10.1177/014662167700100306

M. Lawton and E. Brody, ASSESSMENT OF OLDER PEOPLE, Nursing Research, vol.19, issue.3, pp.179-86, 1969.
DOI : 10.1097/00006199-197005000-00029

I. Rosow and N. Breslau, A Guttman Health Scale for the Aged, Journal of Gerontology, vol.21, issue.4, pp.556-565, 1966.
DOI : 10.1093/geronj/21.4.556

D. Commenges, L. Letenneur, P. Joly, A. Alioum, and J. Dartigues, Modelling age-specific risk: application to dementia, Statistics in Medicine, vol.17, issue.17, pp.1973-88, 1998.
DOI : 10.1002/(SICI)1097-0258(19980915)17:17<1973::AID-SIM892>3.0.CO;2-5

D. Herrington, T. Howard, G. Hawkins, D. Reboussin, J. Xu et al., Estrogen-Receptor Polymorphisms and Effects of Estrogen Replacement on High-Density Lipoprotein Cholesterol in Women with Coronary Disease, New England Journal of Medicine, vol.346, issue.13, pp.967-74, 2002.
DOI : 10.1056/NEJMoa012952

J. Ryan, J. Scali, I. Carriere, K. Peres, O. Rouaud et al., Oestrogen receptor polymorphisms and late-life depression, The British Journal of Psychiatry, vol.199, issue.2, pp.126-157, 2011.
DOI : 10.1192/bjp.bp.111.091751
URL : https://hal.archives-ouvertes.fr/inserm-00624752

K. Urakami, Y. Wakutani, K. Wada-isoe, K. Yamagata, Y. Adachi et al., Analysis of Causative Genes and Genetic Risk Factor in Alzheimer's Disease., Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, vol.38, issue.6, pp.769-71, 2001.
DOI : 10.3143/geriatrics.38.769

L. Gennari, D. Merlotti, D. Paola, V. Calabro, A. Becherini et al., Estrogen Receptor Gene Polymorphisms and the Genetics of Osteoporosis: A HuGE Review, American Journal of Epidemiology, vol.161, issue.4, pp.307-327, 2005.
DOI : 10.1093/aje/kwi055

E. Hogervorst, D. Jager, C. Budge, M. Smith, and A. , Serum levels of estradiol and testosterone and performance in different cognitive domains in healthy elderly men and women, Psychoneuroendocrinology, vol.29, issue.3
DOI : 10.1016/S0306-4530(03)00053-2

A. Barron and C. Pike, Sex hormones, aging, and Alzheimer's disease, Front Biosci, vol.4, pp.976-97, 2012.

G. Gillies and S. Mcarthur, Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines, Pharmacological Reviews, vol.62, issue.2, pp.155-98, 2010.
DOI : 10.1124/pr.109.002071

R. Dresner-pollak, R. Kinnar, T. Friedlander, Y. Sharon, N. Rosenmann et al., Estrogen Receptor Beta Gene Variant Is Associated with Vascular Dementia in Elderly Women, Genetic Testing and Molecular Biomarkers, vol.13, issue.3, pp.339-381, 2009.
DOI : 10.1089/gtmb.2008.0129

L. Goumidi, K. Dahlman-wright, I. Tapia-paez, H. Matsson, F. Pasquier et al., Study of Estrogen Receptor-alpha and Receptor-beta Gene Polymorphisms on Alzheimer's Disease, J Alzheimers Dis, 2011.

K. Pettersson, F. Delaunay, and J. Gustafsson, Estrogen receptor ?? acts as a dominant regulator of estrogen signaling, Oncogene, vol.19, issue.43, pp.4970-4978, 2000.
DOI : 10.1038/sj.onc.1203828

P. Pace, J. Taylor, S. Suntharalingam, R. Coombes, and S. Ali, Human Estrogen Receptor ?? Binds DNA in a Manner Similar to and Dimerizes with Estrogen Receptor ??, Journal of Biological Chemistry, vol.272, issue.41, pp.25832-25840, 1997.
DOI : 10.1074/jbc.272.41.25832

D. Stone, I. Rozovsky, T. Morgan, C. Anderson, and C. Finch, Increased synaptic sprouting in response to estrogen via an apolipoprotein E-dependent mechanism: implications for Alzheimer's disease, J Neurosci, vol.18, pp.3180-3185, 1998.

H. Zheng, H. Xu, S. Uljon, R. Gross, K. Hardy et al., Modulation of Abeta peptides by estrogen in mouse models, Journal of Neurochemistry, vol.80, issue.1, pp.191-197, 2002.
DOI : 10.1046/j.0022-3042.2001.00690.x

R. Srivastava, N. Srivastava, M. Averna, R. Lin, K. Korach et al., Estrogen Up-regulates Apolipoprotein E (ApoE) Gene Expression by Increasing ApoE mRNA in the Translating Pool via the Estrogen Receptor ??-Mediated Pathway, Journal of Biological Chemistry, vol.272, issue.52, pp.33360-33366, 1997.
DOI : 10.1074/jbc.272.52.33360

G. Rippon, M. Tang, J. Lee, R. Lantigua, M. Medrano et al., Familial Alzheimer disease in Latinos: Interaction between APOE, stroke, and estrogen replacement, Neurology, vol.66, issue.1, pp.35-40, 2006.
DOI : 10.1212/01.wnl.0000191300.38571.3e

J. Ryan, I. Carriere, J. Scali, J. Dartigues, C. Tzourio et al., Characteristics of hormone therapy, cognitive function, and dementia: The prospective 3C Study, Neurology, vol.73, issue.21, pp.1729-1766, 2009.
DOI : 10.1212/WNL.0b013e3181c34b0c
URL : https://hal.archives-ouvertes.fr/inserm-00492858

J. Ioannidis, I. Stavrou, T. Trikalinos, C. Zois, M. Brandi et al., Association of Polymorphisms of the Estrogen Receptor ?? Gene With Bone Mineral Density and Fracture Risk in Women: A Meta-Analysis, Journal of Bone and Mineral Research, vol.85, issue.11, pp.2048-60, 2002.
DOI : 10.1359/jbmr.2002.17.11.2048