Does overall diet in midlife predict future aging phenotypes? A cohort study. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles The American Journal of Medicine Year : 2013

Does overall diet in midlife predict future aging phenotypes? A cohort study.


BACKGROUND: The impact of diet on specific age-related diseases has been studied extensively, but few investigations have adopted a more holistic approach to determine the association of diet with overall health at older ages. We examined whether diet, assessed in midlife, using dietary patterns and adherence to the Alternative Healthy Eating Index (AHEI), is associated with aging phenotypes, identified after a mean 16-year follow-up. METHODS: Data were drawn from the Whitehall II cohort study of 5350 adults (age 51.3±5.3 years, 29.4% women). Diet was assessed at baseline (1991-1993). Mortality, chronic diseases, and functioning were ascertained from hospital data, register linkage, and screenings every 5 years and were used to create 5 outcomes at follow-up: ideal aging (free of chronic conditions and high performance in physical, mental, and cognitive functioning tests; 4%), nonfatal cardiovascular event (7.3%), cardiovascular death (2.8%), noncardiovascular death (12.7%), and normal aging (73.2%). RESULTS: Low adherence to the AHEI was associated with an increased risk of cardiovascular and noncardiovascular death. In addition, participants with a "Western-type" diet (characterized by high intakes of fried and sweet food, processed food and red meat, refined grains, and high-fat dairy products) had lower odds of ideal aging (odds ratio for top vs bottom tertile: 0.58; 95% confidence interval, 0.36-0.94; P=.02), independently of other health behaviors. CONCLUSIONS: By considering healthy aging as a composite of cardiovascular, metabolic, musculoskeletal, respiratory, mental, and cognitive function, the present study offers a new perspective on the impact of diet on aging phenotypes.
Fichier principal
Vignette du fichier
Akbaraly_Am_J_Med_126_411Online_Appendix.pdf (241.62 Ko) Télécharger le fichier
Akbaraly_Am_J_Med_126_411.pdf (412.85 Ko) Télécharger le fichier
Akbaraly_Am_J_Med_126_411TABLES.doc (133.5 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
Format : Other

Dates and versions

inserm-00828110 , version 1 (30-05-2013)



Tasnime N. Akbaraly, Séverine Sabia, Gareth Hagger-Johnson, Adam G. Tabak, Martin J. Shipley, et al.. Does overall diet in midlife predict future aging phenotypes? A cohort study.: Overall Diet and Aging Phenotypes. The American Journal of Medicine, 2013, 126 (5), pp.411-419.e3. ⟨10.1016/j.amjmed.2012.10.028⟩. ⟨inserm-00828110⟩
426 View
356 Download



Gmail Facebook Twitter LinkedIn More