In the shadow of the wrinkle: experimental models. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Journal of Cosmetic Dermatology Année : 2012

In the shadow of the wrinkle: experimental models.

Résumé

Research on aging has run for decades, and knowledge on the biologic process of skin chronological and photoaging is still increasing thanks to read across results generated between human, animal, and in vitro studies. However, wrinkles should not be considered to result only from the aging process. There are few reports on specific wrinkle histological features compared to the surrounding skin, and there is thus a need in really wrinkling skin animal and in vitro models. UV-irradiated Hr mouse is a good model because it develops wrinkles. Nevertheless, as mouse skin is somehow different from human skin, the innovative model of wrinkling human skin xenograft on SCID mice seems to be really promising. Concerning in vitro and ex vivo models, although there have been considerable advances in reconstructing realistic aged skins, there is still a lack of in vitro wrinkling skin model, and unfortunately, this gap will probably be difficult to fill.

Domaines

Immunologie

Dates et versions

inserm-00826893 , version 1 (28-05-2013)

Identifiants

Citer

Philippe Humbert, Céline Viennet, Kévin Legagneux, François Grandmottet, Sophie Robin, et al.. In the shadow of the wrinkle: experimental models.. Journal of Cosmetic Dermatology, 2012, 11 (1), pp.79-83. ⟨10.1111/j.1473-2165.2011.00601.x⟩. ⟨inserm-00826893⟩

Collections

INSERM UNIV-FCOMTE
87 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More