Neuroblastoma and tooth abnormalities: a common history?

Abstract : Neuroblastoma, a malignant tumor of the sympathetic nervous system and the most common extracranial solid tumor in childhood, arises from embryonic neural crest cells. Tooth development begins before birth and continues for 12-14 years with the development of the third molar for several years. Abnormal events that occur during odontogenesis give permanent damage. Whereas the impact of multimodal therapy including radiotherapy and chemotherapy is major in tooth development defects1 we suggested that the particular association between neuroblastoma and the occurrence of missing teeth is not necessary due to treatment effects but considered the hypothesis of a common underlying genetic defect because of common cell origin...