Skip to Main content Skip to Navigation
Journal articles

Thiocolchicoside a semi-synthetic derivative of the Glory Lily: a new weapon to fight metastatic bone resorption?: Thiocolchicoside to treat metastatic bone

Abstract : Metastatic bone disease is a serious clinical complication for the treatment of patients with advanced cancer, but few therapeutic options are currently available. Bisphosphonates are an established standard care for these patients, but new treatments are now emerging, including the use of monoclonal antibodies targeting the RANK ligand. In this issue of the BJP, Reuter et al. provide evidence that thiocolchicoside, a semi-synthetic derivative of the naturally occurring colchicoside, extracted from the seeds of Gloriosa superba (Liliaceae), prevented osteoclactogenesis by suppressing RANK ligand-mediated NF-κB activation. Thiolcolchicoside may thus represent an attractive therapeutic option for the management of bone metastatic disease.
Document type :
Journal articles
Complete list of metadatas

Cited literature [8 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00823463
Contributor : Olivier Micheau <>
Submitted on : Friday, May 17, 2013 - 9:17:24 AM
Last modification on : Tuesday, December 1, 2020 - 9:42:02 AM
Long-term archiving on: : Tuesday, April 4, 2017 - 7:46:49 AM

Files

Brit_J_Pharmacol_Micheau_final...
Files produced by the author(s)

Identifiers

Citation

Olivier Micheau, Florent Dufour, Henning Walczak. Thiocolchicoside a semi-synthetic derivative of the Glory Lily: a new weapon to fight metastatic bone resorption?: Thiocolchicoside to treat metastatic bone. British Journal of Pharmacology, Wiley, 2012, 165 (7), pp.2124-6. ⟨10.1111/j.1476-5381.2011.01792.x⟩. ⟨inserm-00823463⟩

Share

Metrics

Record views

333

Files downloads

907