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Death receptors as targets in cancer

Abstract : Anti-tumour therapies based on the use PARAs (pro-apoptotic receptor agonists), including TRAIL (TNF-Related Apoptosis inducing Ligand) or monoclonal antibodies targeting TRAIL-R1 or TRAIL-R2, have been disappointing so far, despite clear evidence of clinical activity and lack of adverse events for the vast majority of these compounds, whether combined or not with conventional or targeted anti-cancer therapies. This brief review aims at discussing the possible reasons for the lack of apparent success of these therapeutic approaches and at providing hints in order to rationally design optimal protocols based on our current understanding of TRAIL signalling regulation or resistance for future clinical trials.
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https://www.hal.inserm.fr/inserm-00823459
Contributor : Olivier Micheau <>
Submitted on : Thursday, May 1, 2014 - 7:00:03 AM
Last modification on : Wednesday, June 10, 2020 - 2:06:49 PM
Long-term archiving on: : Thursday, July 31, 2014 - 10:35:51 AM

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  • HAL Id : inserm-00823459, version 1

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Olivier Micheau, Sarah Shirley, Florent Dufour. Death receptors as targets in cancer. 2014. ⟨inserm-00823459⟩

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