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LupusQoL-FR is valid to assess quality of life in patients with systemic lupus erythematosus.

Abstract : OBJECTIVE: To cross-culturally adapt the LupusQoL into French, to test its measurement properties and to further investigate its domain structure. METHODS: The cultural adaptation process according to guidelines and pre-testing resulted in the LupusQoL-FR. SLE patients completed the LupusQoL-FR at baseline, 15 days, 3 months and 6 months. Validity was studied through content and construct validity (factorial and Rasch analysis for structural validity, Spearman's correlation and Mann-Whitney tests for external validity). Cronbach's α and intra-class correlation coefficients were computed for reliability. The standardized response mean was computed to evaluate responsiveness. RESULTS: In all, 182 patients, age 39.6 (10.6) years, mostly outpatients [mean SELENA-SLEDAI 2.6 (3.5)] were recruited. Factor analysis with eight imposed factors was very close to the original LupusQoL. A screeplot with parallel analysis showed that LupusQoL domains could be aggregated in two physical and mental scales. Both eight- and two-factor structures showed a good Rasch fit, internal consistency (Cronbach's α: 0.85-0.95), and test-retest reliability (intra-class correlation coefficient 0.79-0.95). External convergent (correlation with SF-36, r=0.59-0.78) and divergent validity (according to SELENA-SLEDAI) were also satisfactory. CONCLUSION: The LupusQoL-FR is valid to assess quality of life in SLE patients. A two-factor structure of physical and mental aggregated scales is a valid alternative to the original eight-domain structure.
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https://www.hal.inserm.fr/inserm-00821512
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Submitted on : Friday, May 10, 2013 - 3:14:27 PM
Last modification on : Tuesday, October 27, 2020 - 2:35:49 PM

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Hervé Devilliers, Zahir Amoura, Jean-Francois Besancenot, Bernard Bonnotte, Jean-Louis Pasquali, et al.. LupusQoL-FR is valid to assess quality of life in patients with systemic lupus erythematosus.. Rheumatology, Oxford University Press (OUP), 2012, 51 (10), pp.1906-15. ⟨10.1093/rheumatology/kes165⟩. ⟨inserm-00821512⟩

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