Extravasation of liposomal doxorubicin induces irritant reaction without vesicant injury.

Elsa Curtit; Loïc Chaigneau; Julien Pauchot; Thierry Nguyen; Virginie Nerich; Fernando Bazan; Antoine Thiery-Vuillemin; Martin Demarchi; Xavier Pivot; Cristian Villanueva

Extravasation of liposomal doxorubicin induces irritant reaction without vesicant injury.

Elsa Curtit ^{1, 2, 3, *} Loïc Chaigneau ¹ Julien Pauchot ^{2, 4, 5} Thierry Nguyen ¹ Virginie Nerich ^{2, 3, 6} Fernando Bazan ¹ Antoine Thiery-Vuillemin ^{1, 2, 3} Martin Demarchi ¹ Xavier Pivot ^{1, 2, 3} Cristian Villanueva ¹

* Auteur correspondant

1 Service d'oncologie Médicale

2 UFC - Université de Franche-Comté

3 HOTE GREFFON - Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)

4 I4S - Intervention, innovation, imagerie, ingénierie en santé - UFC

5 Service de Chirurgie Orthopédique Traumatologique et Plastique [Besançon]

6 Pharmacie à usage interne

Abstract : Anthracycline extravasation is an uncommon but very serious complication. Very few data are available in the literature concerning the consequences and the management of extravasation of liposomal doxorubicin. This report describes the cases of two patients with liposomal doxorubicin extravasation who developed irritant reaction without vesicant or necrotic lesions. It is concordant with other cases described in the literature and suggests that extravasation of liposomal doxorubicin can be relatively well tolerated. The process applied to extravasations of irritant and non-vesicant agents could be used to manage extravasations of liposomal doxorubicin.

Type de document :

Article dans une revue

Anticancer Research, International Institute of Anticancer Research, 2012, 32 (4), pp.1481-3

Domaine :

Sciences du Vivant [q-bio] / Immunologie

Liste complète des métadonnées

https://www.hal.inserm.fr/inserm-00821491
Contributeur : Philippe Saas <>
Soumis le : vendredi 10 mai 2013 - 14:20:09
Dernière modification le : lundi 9 juillet 2018 - 13:12:02

Extravasation of liposomal doxorubicin induces irritant reaction without vesicant injury.

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Extravasation of liposomal doxorubicin induces irritant reaction without vesicant injury.

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