S. Embury, R. Hebbel, N. Mohandas, M. Steinberg, S. Embury et al., Pathogenesis of vasoocclusion Sickle Cell Disease: Basic Principles and Clinical Practice, pp.311-337, 1994.

R. Hoover, R. Rubin, G. Wise, and R. Warren, Adhesion of normal and sickle erythrocytes to endothelial monolayer cultures, Blood, vol.54, issue.4, pp.872-878, 1979.

R. Hebbel, O. Yamada, C. Moldow, H. Jacob, J. White et al., Abnormal Adherence of Sickle Erythrocytes to Cultured Vascular Endothelium, Journal of Clinical Investigation, vol.65, issue.1, pp.154-60, 1980.
DOI : 10.1172/JCI109646

B. Gee and O. Platt, Sickle reticulocytes adhere to VCAM-1, Blood, vol.85, issue.1, pp.268-74, 1995.

C. Joneckis, R. Ackley, E. Orringer, E. Wayner, and L. Parise, Integrin alpha 4 beta 1 and glycoprotein IV (CD36) are expressed on circulating reticulocytes in sickle cell anemia, Blood, vol.82, issue.12, pp.3548-55, 1993.

J. Brittain, J. Han, K. Ataga, E. Orringer, and L. Parise, Mechanism of CD47-induced ??4??1 Integrin Activation and Adhesion in Sickle Reticulocytes, Journal of Biological Chemistry, vol.279, issue.41, pp.42393-402, 2004.
DOI : 10.1074/jbc.M407631200

A. Kumar, J. Eckmam, R. Swerlick, and T. Wick, Phorbol ester stimulation increases sickle erythrocyte adherence to endothelium: a novel pathway involving alpha 4 beta 1 integrin receptors on sickle reticulocytes and fibronectin, Blood, vol.88, issue.11, pp.4348-58, 1996.

M. Udani, Q. Zen, M. Cottman, N. Leonard, S. Jefferson et al., Basal cell adhesion molecule/lutheran protein. The receptor critical for sickle cell adhesion to laminin., Journal of Clinical Investigation, vol.101, issue.11, pp.2550-2558, 1998.
DOI : 10.1172/JCI1204

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC508844

E. Nemer, W. Gane, P. Colin, Y. Bony, V. Rahuel et al., The Lutheran Blood Group Glycoproteins, the Erythroid Receptors for Laminin, Are Adhesion Molecules, Journal of Biological Chemistry, vol.273, issue.27, pp.16686-93, 1998.
DOI : 10.1074/jbc.273.27.16686

S. Parsons, G. Lee, F. Spring, T. Willig, L. Peters et al., Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity, Blood, vol.97, issue.1, pp.312-332, 2001.
DOI : 10.1182/blood.V97.1.312

C. Hillery, M. Du, R. Montgomery, and J. Scott, Increased adhesion of erythrocytes to components of the extracellular matrix: isolation and characterization of a red blood cell lipid that binds thrombospondin and laminin, Blood, vol.87, issue.11, pp.4879-86, 1996.

P. Hines, Q. Zen, S. Burney, D. Shea, K. Ataga et al., Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion, Blood, vol.101, issue.8, pp.3281-3288, 2003.
DOI : 10.1182/blood-2001-12-0289

E. Gauthier, C. Rahuel, M. Wautier, E. Nemer, W. Gane et al., Protein Kinase A-dependent Phosphorylation of Lutheran/Basal Cell Adhesion Molecule Glycoprotein Regulates Cell Adhesion to Laminin ??5, Journal of Biological Chemistry, vol.280, issue.34, pp.30055-62, 2005.
DOI : 10.1074/jbc.M503293200

E. Nemer, W. Wautier, M. Rahuel, C. Gane, P. Hermand et al., Endothelial Lu/BCAM glycoproteins are novel ligands for red blood cell ??4??1integrin: role in adhesion of sickle red blood cells to endothelial cells, Blood, vol.109, issue.8, pp.3544-51, 2007.
DOI : 10.1182/blood-2006-07-035139

I. Okpala, The intriguing contribution of white blood cells to sickle cell disease ??? a red cell disorder, Blood Reviews, vol.18, issue.1, pp.65-73, 2004.
DOI : 10.1016/S0268-960X(03)00037-7

I. Okpala, Leukocyte adhesion and the pathophysiology of sickle cell disease, Current Opinion in Hematology, vol.13, issue.1, pp.40-44, 2006.
DOI : 10.1097/01.moh.0000190108.62414.06

M. Abboud, J. Laver, and C. Blau, Granulocytosis causing sickle-cell crisis, The Lancet, vol.351, issue.9107, p.959, 1998.
DOI : 10.1016/S0140-6736(05)60614-9

B. Adler, D. Salzman, M. Carabasi, W. Vaughan, V. Reddy et al., Fatal sickle cell crisis after granulocyte colony-stimulating factor administration, Blood, vol.97, issue.10, pp.3313-3317, 2001.
DOI : 10.1182/blood.V97.10.3313

O. Platt, D. Brambilla, W. Rosse, P. Milner, O. Castro et al., Mortality In Sickle Cell Disease -- Life Expectancy and Risk Factors for Early Death, New England Journal of Medicine, vol.330, issue.23, pp.1639-1683, 1994.
DOI : 10.1056/NEJM199406093302303

O. Castro, D. Brambilla, B. Thorington, C. Reindorf, R. Scott et al., The acute chest syndrome in sickle cell disease: incidence and risk factors. The Cooperative Study of Sickle Cell Disease, Blood, vol.84, issue.2, pp.643-652, 1994.

K. Ohene-frempong, S. Weiner, L. Sleeper, S. Miller, S. Embury et al., Cerebrovascular accidents in sickle cell disease: rates and risk factors, Blood, vol.91, issue.1, pp.288-94, 1998.

D. Powars, Management Of Cerebral Vasculopathy In Children With Sickle Cell Anaemia, British Journal of Haematology, vol.29, issue.4, pp.666-78, 2000.
DOI : 10.1016/0887-8994(96)00045-8

T. Kinney, L. Sleeper, W. Wang, R. Zimmerman, C. Pegelow et al., Silent Cerebral Infarcts in Sickle Cell Anemia: A Risk Factor Analysis, PEDIATRICS, vol.103, issue.3, pp.640-645, 1999.
DOI : 10.1542/peds.103.3.640

E. Fadlon, S. Vordermeier, T. Pearson, A. Mire-sluis, D. Dumonde et al., Blood polymorphonuclear leukocytes from the majority of sickle cell patients in the crisis phase of the disease show enhanced adhesion to vascular endothelium and increased expression of CD64, Blood, vol.91, issue.1, pp.266-74, 1998.

K. Mathews, M. Mcleod, D. Merges, C. Cao, J. Lutty et al., Neutrophils and leucocyte adhesion molecules in sickle cell retinopathy, British Journal of Ophthalmology, vol.86, issue.6, pp.684-90, 2002.
DOI : 10.1136/bjo.86.6.684

R. Zennadi, B. Moeller, E. Whalen, M. Batchvarova, K. Xu et al., Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo, Blood, vol.110, issue.7, pp.2708-2725, 2007.
DOI : 10.1182/blood-2006-11-056101

A. Turhan, L. Weiss, N. Mohandas, B. Coller, and P. Frenette, Primary role for adherent leukocytes in sickle cell vascular occlusion: A new paradigm, Proceedings of the National Academy of Sciences, vol.99, issue.5, pp.3047-51, 2002.
DOI : 10.1073/pnas.052522799

T. Hofstra, V. Kalra, H. Meiselman, and T. Coates, Sickle erythrocytes adhere to polymorphonuclear neutrophils and activate the neutrophil respiratory burst, Blood, vol.87, issue.10, pp.4440-4447, 1996.

E. Finnegan, A. Turhan, D. Golan, and G. Barabino, Adherent leukocytes capture sickle erythrocytes in an in vitro flow model of vaso-occlusion, American Journal of Hematology, vol.93, issue.4, pp.266-75, 2007.
DOI : 10.1002/ajh.20819

J. Brittain, C. Knoll, K. Ataga, E. Orringer, and L. Parise, Fibronectin bridges monocytes and reticulocytes via integrin ??4??1, British Journal of Haematology, vol.3, issue.6, pp.872-81, 2008.
DOI : 10.1073/pnas.052522799

R. Zennadi, A. Chien, K. Xu, M. Batchvarova, and M. Telen, Sickle red cells induce adhesion of lymphocytes and monocytes to endothelium, Blood, vol.112, issue.8, pp.3474-83, 2008.
DOI : 10.1182/blood-2008-01-134346

S. Charache, M. Terrin, R. Moore, G. Dover, F. Barton et al., Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia, New England Journal of Medicine, vol.332, issue.20, pp.1317-1339, 1995.
DOI : 10.1056/NEJM199505183322001

W. Ortyn, B. Hall, T. George, K. Frost, D. Basiji et al., Sensitivity measurement and compensation in spectral imaging, Cytometry Part A, vol.175, issue.8, pp.852-62, 2006.
DOI : 10.1002/cyto.a.20306

G. Daniels, Lutheran Blood Group System Human Blood Groups, Blackwell Science, pp.356-84, 1995.

C. Rahuel, L. Van-kim, C. Mattei, M. Cartron, J. et al., A unique gene encodes spliceoforms of the B-cell adhesion molecule cell surface glycoprotein of epithelial cancer and of the Lutheran blood group glycoprotein, Blood, vol.88, issue.5, pp.1865-72, 1996.

A. Turhan, P. Jenab, P. Bruhns, J. Ravetch, B. Coller et al., Intravenous immune globulin prevents venular vaso-occlusion in sickle cell mice by inhibiting leukocyte adhesion and the interactions between sickle erythrocytes and adherent leukocytes, Blood, vol.103, issue.6, pp.2397-400, 2004.
DOI : 10.1182/blood-2003-07-2209

J. Belcher, P. Marker, J. Weber, R. Hebbel, and G. Vercellotti, Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vasoocclusion, Blood, vol.96, issue.7, pp.2451-2460, 2000.

T. Wun, M. Cordoba, A. Rangaswami, A. Cheung, and T. Paglieroni, Activated monocytes and platelet-monocyte aggregates in patients with sickle cell disease*, Clinical and Laboratory Haematology, vol.5, issue.2, pp.81-89, 2002.
DOI : 10.1016/S0022-2143(97)90005-6

A. Shet, O. Aras, K. Gupta, M. Hass, D. Rausch et al., Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes, Blood, vol.102, issue.7, pp.2678-83, 2003.
DOI : 10.1182/blood-2003-03-0693

L. Lard, F. Mul, M. De-haas, D. Roos, and A. Duits, Neutrophil activation in sickle cell disease, J Leukoc Biol, vol.66, issue.3, pp.411-416, 1999.

M. Odievre, V. Bony, M. Benkerrou, C. Lapoumeroulie, C. Alberti et al., Modulation of erythroid adhesion receptor expression by hydroxyurea in children with sickle cell disease, Haematologica, vol.93, issue.4, pp.502-512, 2008.
DOI : 10.3324/haematol.12070

A. Saleh, H. Hillen, and A. Duits, Levels of Endothelial, Neutrophil and Platelet-Specific Factors in Sickle Cell Anemia Patients during Hydroxyurea Therapy, Acta Haematologica, vol.102, issue.1, pp.31-38, 1999.
DOI : 10.1159/000040964

M. Benkerrou, C. Delarche, L. Brahimi, M. Fay, E. Vilmer et al., Hydroxyurea corrects the dysregulated L-selectin expression and increased H2O2 production of polymorphonuclear neutrophils from patients with sickle cell anemia, Blood, vol.99, issue.7, pp.2297-303, 2002.
DOI : 10.1182/blood.V99.7.2297

C. Lanaro, C. Franco-penteado, D. Albuqueque, S. Saad, N. Conran et al., Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapy, Journal of Leukocyte Biology, vol.85, issue.2, pp.235-277, 2009.
DOI : 10.1189/jlb.0708445

I. Okpala, Y. Daniel, R. Haynes, D. Odoemene, and J. Goldman, Relationship between the clinical manifestations of sickle cell disease and the expression of adhesion molecules on white blood cells, European Journal of Haematology, vol.69, issue.3, pp.135-179, 2002.
DOI : 10.1034/j.1600-0609.2002.02775.x

L. Styles, B. Lubin, E. Vichinsky, S. Lawrence, M. Hua et al., Decrease of very late activation antigen-4 and CD36 on reticulocytes in sickle cell patients treated with hydroxyurea, Blood, vol.89, issue.7, pp.2554-2563, 1997.

Y. Shimizu, V. Seventer, G. Horgan, K. Shaw, and S. , Regulated expression and binding of three VLA (??1) integrin receptors on T cells, Nature, vol.345, issue.6272, pp.250-253, 1990.
DOI : 10.1038/345250a0