White adipose tissue overproduces the lipid-mobilizing factor zinc α2-glycoprotein in chronic kidney disease.

Abstract : Chronic kidney disease (CKD) is frequently associated with protein-energy wasting, a recognized strong predictive factor of mortality. Zinc α2-glycoprotein (ZAG) is a new adipokine involved in body weight control through its lipid-mobilizing activity. Here we tested whether the uremic environment in CKD could alter ZAG production by white adipose tissue and contribute to CKD-associated metabolic disturbances. Compared with normal plasma, uremic plasma induced a significant increase in ZAG synthesis (124%), was associated with a significant increase in basal lipolysis (31%), and significantly blunted lipogenesis (-53%) in 3T3-L1 adipocytes in vitro. In 5/6 nephrectomized rats and mice in vivo, there was a significant decrease in white adipose tissue accretion (-44% and -43%, respectively) and a significantly higher white adipose tissue content of ZAG protein than in sham-operated, pair-fed control animals (498% and 106%, respectively). Subcutaneous white adipose tissue biopsies from patients with end-stage renal disease exhibited a higher content of ZAG (573%) than age-matched controls. Thus, the ZAG content is increased in white adipose tissue from patients or animal models with CKD. Overproduction of ZAG in CKD could be a major contributor to metabolic disturbances associated with CKD.
Type de document :
Article dans une revue
Kidney International, Nature Publishing Group, 2013, 83 (5), pp.878-86. 〈10.1038/ki.2013.9〉
Liste complète des métadonnées

Littérature citée [44 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00819676
Contributeur : Evelyne Vericel <>
Soumis le : vendredi 2 août 2013 - 07:00:05
Dernière modification le : samedi 22 septembre 2018 - 01:16:41
Document(s) archivé(s) le : mardi 4 avril 2017 - 02:28:24

Fichiers

Pelletier_et_al_Kidney_Int_201...
Fichiers produits par l'(les) auteur(s)

Identifiants

Citation

Caroline Pelletier, Laetitia Koppe, Marine Croze, Emilie Kalbacher, Roxane Vella, et al.. White adipose tissue overproduces the lipid-mobilizing factor zinc α2-glycoprotein in chronic kidney disease.. Kidney International, Nature Publishing Group, 2013, 83 (5), pp.878-86. 〈10.1038/ki.2013.9〉. 〈inserm-00819676〉

Partager

Métriques

Consultations de la notice

483

Téléchargements de fichiers

1186