Indoleamine 2,3-dioxygenase activity as a potential biomarker of immune suppression during visceral leishmaniasis.

Jean-Pierre Gangneux 1, * Yves Poinsignon 2 Ludovic Donaghy 3 Laurence Amiot 1 Karin Tarte 4, 5 Charles Mary 6 Florence Robert-Gangneux 1
* Auteur correspondant
1 Irset - Institut de recherche, santé, environnement et travail
2 Service de médecine interne
3 Service de Parasitologie-Mycologie [Rennes]
4 HITC - Service d'Hématologie, Immunologie et de Thérapie Cellulaire
5 MiCa - Microenvironnement et cancer
6 Laboratoire de parasitologie-mycologie
Abstract : Leishmania parasites induce an immunomodulation by subverting the host immune response towards a CD4(+) Th2 lymphocytic cell response that favors parasite persistence. Here, we report that after successful treatment of visceral leishmaniasis due to Leishmania infantum, an immune reconstitution syndrome revealing hip septic arthritis was associated with a switch from Th2 towards a Th1 cytokine profile, and a decrease in the level of immunomodulating factors, such as soluble HLA-G and indoleamine 2,3-dioxygenase (IDO) activity. We then measured IDO activity in a cohort of 39 patients and uninfected control subjects. Results showed significantly enhanced IDO activity in patients with visceral Leishmania infection, compared with uninfected control subjects (P < 0.001), but also compared with treated patients (P < 0.05). A decrease in IDO activity could constitute a relevant biomarker for the restoration of the immune response during visceral leishmaniasis.
keyword : Indoleamine 2 3-dioxygenase immune reconstitution syndrome visceral leishmaniasis Leishmania HLA-G immune response
Type de document :
Article dans une revue
Innate Immunity, 2013, 19 (6), pp.564-568. 〈10.1177/1753425912473170〉
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http://www.hal.inserm.fr/inserm-00818884
Contributeur : Clémence Martin <>
Soumis le : lundi 29 avril 2013 - 14:53:18
Dernière modification le : lundi 27 août 2018 - 09:44:38

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Jean-Pierre Gangneux, Yves Poinsignon, Ludovic Donaghy, Laurence Amiot, Karin Tarte, et al.. Indoleamine 2,3-dioxygenase activity as a potential biomarker of immune suppression during visceral leishmaniasis.. Innate Immunity, 2013, 19 (6), pp.564-568. 〈10.1177/1753425912473170〉. 〈inserm-00818884〉

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