B. Adzu, S. Amos, M. Amizan, and K. Gamaniel, Evaluation of the antidiarrheal effects of Zizyphus spina-christi stem bark in rats, Acta Trop, vol.7, pp.245-250, 2003.

J. Bickii, G. Tchouya, J. Tchouankeu, and E. Tsamo, Antimalarial activity in crude extracts of some Cameroonian medicinal plants, African Journal of Traditional, Complementary and Alternative Medicines, vol.4, issue.1, pp.107-111, 2006.
DOI : 10.4314/ajtcam.v4i1.31200

J. Okokon, B. Antia, A. Igboasoiyi, E. Essien, and H. Mbagwu, Evaluation of antiplasmodial activity of ethanolic seed extract of Picralima nitida, Journal of Ethnopharmacology, vol.111, issue.3, pp.464-467, 2007.
DOI : 10.1016/j.jep.2006.12.016

G. Taïwe, E. Bum, E. Talla, T. Dimo, N. Weiss et al., Antipyretic and antinociceptive effects of Nauclea latifolia root decoction and possible mechanisms of action

T. Tchacondo, S. Karou, K. Batawila, A. Agban, K. Ouro-bang-'na et al., Herbal Remedies And Their Adverse Effects In Tem Tribe Traditional Medicine In Togo, African Journal of Traditional, Complementary and Alternative Medicines, vol.8, issue.1, pp.45-60, 2011.
DOI : 10.4314/ajtcam.v8i1.60522

K. Anand, B. Singh, D. Chand, B. Chandan, and V. Gupta, Effect of Zizyphus sativa leaves on blood glucose levels in normal and alloxan-diabetic rats, Journal of Ethnopharmacology, vol.27, issue.1-2, pp.121-125, 1989.
DOI : 10.1016/0378-8741(89)90084-6

R. Tschesche and E. Kaubmann, The Alkaloids, pp.165-205

C. Benammar, A. Hichami, A. Yessoufou, A. Simonin, M. Belarbi et al., Zizyphus lotus L. (Desf.) modulates antioxidant activity and human T-cell proliferation, BMC Complementary and Alternative Medicine, vol.49, issue.1, pp.101-110, 2010.
DOI : 10.1016/j.plipres.2010.01.002

M. Duwiejua, E. Woode, and D. Obiri, Pseudo-akuammigine, an alkaloid from Picralima nitida seeds, has anti-inflammatory and analgesic actions in rats, Journal of Ethnopharmacology, vol.81, issue.1, pp.8173-79, 2002.
DOI : 10.1016/S0378-8741(02)00058-2

T. Fakeye, O. Itiola, and H. Odelola, Evaluation of the antimicrobial property of the stem bark ofPicralima nitida (Apocynaceae), Phytotherapy Research, vol.25, issue.5, pp.368-370, 2000.
DOI : 10.1002/1099-1573(200008)14:5<368::AID-PTR615>3.0.CO;2-X

O. Mathew, A. Ogochukwu, and U. Michael, Antiulcer activity of methanolic extract and fractions of Picralima nitida seeds(Apocynacaea) in rats, Asian Pacific Journal of Tropical Medicine, vol.4, issue.1, pp.13-15, 2011.
DOI : 10.1016/S1995-7645(11)60023-0

A. Igboasoiyi, E. Essien, O. Eseyin, and G. Ubam, Screening of the seed of Picralima nitida for hypoglycaemic activity, Pak J Biol Sci, vol.10, issue.5, pp.828-830, 2007.

C. Aguwa, C. Ukwe, S. Inya-agha, and J. Okonta, Antidiabetic effect of Picralima nitida aqueous seed extract in experimental rabbit model

S. Inya-agha, S. Ezea, and O. Odukoya, Evaluation of Picralima nitida hypoglycaemic activity, toxicity and analytical standards, Int J Pharmacol, issue.2, pp.576-580, 2006.
DOI : 10.1055/s-2006-949825

URL : https://doaj.org/article/136fa7fac7044858b80d3b1a6eeb0951

J. Atègbo, O. Grissa, A. Yessoufou, A. Hichami, K. Dramane et al., Modulation of Adipokines and Cytokines in Gestational Diabetes and Macrosomia, The Journal of Clinical Endocrinology & Metabolism, vol.91, issue.10, pp.914137-4143, 2006.
DOI : 10.1210/jc.2006-0980

O. Grissa, J. Atègbo, A. Yessoufou, Z. Tabka, A. Miled et al., Antioxidant status and circulating lipids are altered in human gestational diabetes and macrosomia, Translational Research, vol.150, issue.3, pp.150164-171, 2007.
DOI : 10.1016/j.trsl.2007.03.007

B. Guermouche, A. Yessoufou, N. Soulaimann, H. Merzouk, K. Moutairou et al., n-3 Fatty Acids Modulate T-Cell Calcium Signaling in Obese Macrosomic Rats, Obesity Research, vol.17, issue.11, pp.1744-1753, 2004.
DOI : 10.1038/oby.2004.216

N. Khan, A. Yessoufou, M. Kim, and A. Hichami, N-3 fatty acids modulate Th1 and Th2 dichotomy in diabetic pregnancy and macrosomia, Journal of Autoimmunity, vol.26, issue.4, pp.268-277, 2006.
DOI : 10.1016/j.jaut.2006.03.003

A. Yessoufou and K. Moutairou, Maternal Diabetes in Pregnancy: Early and Long-Term Outcomes on the Offspring and the Concept of ???Metabolic Memory???, Experimental Diabetes Research, vol.15, issue.2, pp.1-12, 2011.
DOI : 10.1016/S0899-9007(98)00004-5

A. Yessoufou, N. Soulaimann, S. Merzouk, K. Moutairou, H. Ahissou et al., N-3 Fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring, International Journal of Obesity, vol.106, issue.5, pp.739-750, 2006.
DOI : 10.1038/sj.ijo.0803211

F. Van-assche, K. Holemans, and L. Aerts, Long-term consequences for offspring of diabetes during pregnancy, British Medical Bulletin, vol.60, issue.1, pp.173-182, 2001.
DOI : 10.1093/bmb/60.1.173

K. Herold, V. Vezys, Q. Sun, D. Viktora, E. Seung et al., Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin, J Immunol, vol.156, pp.3521-3527, 1996.

A. Yessoufou, A. Hichami, P. Besnard, K. Moutairou, and N. Khan, Peroxisome Proliferator-Activated Receptor ?? Deficiency Increases the Risk of Maternal Abortion and Neonatal Mortality in Murine Pregnancy with or without Diabetes Mellitus: Modulation of T Cell Differentiation, Endocrinology, vol.147, issue.9, pp.4410-4418, 2006.
DOI : 10.1210/en.2006-0067

URL : https://hal.archives-ouvertes.fr/hal-00095766

T. Sathyapalan and S. Atkin, Is there a role for immune and anti-inflammatory therapy in type 2 diabetes? Minerva Endocrinol, pp.147-156, 2011.

A. Keita, E. Mariko, and T. Haidara, Etude de l'activité hypoglycémiante des feuilles de Sclerocarya birrea (A. Rich) Hochst. (Anacardiaceae): action de la fraction butanolique de l'extrait aqueux, pp.16-25, 1998.

J. Roe and C. Kuether, The determination of ascorbic acid in whole blood and urine through the 2,4-dinitrophenylhydrazine derivatives of dehydroascorbic acid, J Biol Chem, vol.147, pp.399-407, 1943.

D. Blache and M. Prost, Free radical attack: biological test for human resistance capability. In A lunar-based chemical analysis laboratory, pp.82-98, 1992.

P. Houghton and R. Amala, Laboratory Handbook for the Fractionation of Natural Extracts, p.244, 1998.
DOI : 10.1007/978-1-4615-5809-5

E. Bligh and W. Dyer, A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION, Canadian Journal of Biochemistry and Physiology, vol.37, issue.8, pp.911-917, 1995.
DOI : 10.1139/o59-099

H. Solver and E. Lanza, Quantitative analysis of food fatty acids by capillary gas chromatography, Journal of the American Oil Chemists??? Society, vol.47, issue.12, pp.933-943, 1979.
DOI : 10.1007/BF02674138

A. Rabinovitch, Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM: therapeutic intervention by immunostimulation? Diabetes, pp.613-621, 1994.

A. Muller, P. Schott-ohly, C. Dohle, and H. Gleichmann, Differential Regulation of Th1-Type and Th2-Type Cytokine Profiles in Pancreatic Islets of C57BL/6 and BALB/c Mice by Multiple Low Doses of Streptozotocin, Immunobiology, vol.205, issue.1, pp.35-50, 2002.
DOI : 10.1078/0171-2985-00109

A. Rossini, R. Williams, M. Appel, and A. Like, Complete protection from low-dose streptozotocin-induced diabetes in mice, Nature, vol.74, issue.5684, pp.182-184, 1978.
DOI : 10.1038/276182a0

M. Vercheval, D. Hertogh, R. Pampfer, S. Vanderheyden, I. Michiels et al., Experimental diabetes impairs rat embryo development during the preimplantation period, Diabetologia, vol.12, issue.4, pp.187-191, 1990.
DOI : 10.1007/BF00404794

I. Lopez-soldado and E. Herrera, Different Diabetogenic Response to Moderate Doses of Streptozotocin in Pregnant Rats, and Its Long-Term Consequences in the Offspring, Experimental Diabesity Research, vol.4, issue.2, pp.107-118, 2003.
DOI : 10.1155/EDR.2003.107

A. Aderibigbe, T. Emudianughe, and B. Lawal, Antihyperglycaemic effect of Mangifera indica in rat, Phytotherapy Research, vol.30, issue.6, pp.504-507, 1999.
DOI : 10.1002/(SICI)1099-1573(199909)13:6<504::AID-PTR533>3.0.CO;2-9

W. Borgi, M. Recio, J. Ríos, and N. Chouchane, Anti-inflammatory and analgesic activities of flavonoid and saponin fractions from Zizyphus lotus (L.) Lam., South African Journal of Botany, vol.74, issue.2, pp.320-324, 2008.
DOI : 10.1016/j.sajb.2008.01.009

M. Lenucci, D. Cadinu, M. Taurino, G. Piro, and G. Dalessandro, Antioxidant Composition in Cherry and High-Pigment Tomato Cultivars, Journal of Agricultural and Food Chemistry, vol.54, issue.7, pp.2606-2613, 2006.
DOI : 10.1021/jf052920c

A. Lamien-meda, C. Lamien, M. Compaoré, R. Meda, M. Kiendrebeogo et al., Polyphenol Content and Antioxidant Activity of Fourteen Wild Edible Fruits from Burkina Faso, Molecules, vol.13, issue.3, pp.581-594, 2008.
DOI : 10.3390/molecules13030581

A. Domingues, A. Sartori, L. Valente, M. Golim, A. Siani et al., Uncaria tomentosa Aqueous-ethanol Extract Triggers an Immunomodulation toward a Th2 Cytokine Profile, Phytotherapy Research, vol.20, issue.8, pp.1229-1235, 2011.
DOI : 10.1002/ptr.3549

P. Calder, S. Krauss-etschmann, E. De-jong, C. Dupont, J. Frick et al., Early nutrition and immunity -progress and perspectives, Br J Nutr, vol.96, pp.774-790, 2006.

N. Khan, Polyunsaturated fatty acids in the modulation of T-cell signalling, Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), vol.82, issue.4-6, pp.179-187, 2010.
DOI : 10.1016/j.plefa.2010.02.023

A. Da-conceição, M. Rossi, F. De-oliveira, L. Takser, and J. Lafond, (Rubiaceae) Fruit Extract Affects Mitogen-Activated Protein Kinase Cell Pathways in Human Trophoblast???Derived BeWo Cells: Implications for Placental Development, Journal of Medicinal Food, vol.14, issue.5, pp.483-494, 2011.
DOI : 10.1089/jmf.2009.0279

N. Bacher, M. Tiefenthaler, S. Sturm, H. Stuppner, M. Ausserlechner et al., Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells, British Journal of Haematology, vol.55, issue.5, pp.132615-622, 2006.
DOI : 10.1007/BF02269869

F. Traore, M. Gasquet, M. Laget, H. Guiraud, D. Giorgio et al., Toxicity and genotoxicity of antimalarial alkaloid rich extracts derived from Mitragyna inermis O. Kuntze and Nauclea latifolia, Phytother Res, issue.8, pp.14608-611, 2000.

M. Mesaik, S. Halim, Z. Ul-haq, M. Choudhary, S. Shahnaz et al., Immunosuppressive activity of buxidin and Ebuxenone from Buxus hyrcana, Chem Biol Drug Des, issue.3, pp.75310-317, 2010.
DOI : 10.1111/j.1747-0285.2009.00906.x

D. Yuan, B. Ma, J. Yang, Y. Xie, L. Wang et al., Antiinflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism, Int Immunopharmacol, issue.9, pp.1549-1554, 2009.