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A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation.: SREBP-1a and -1c in muscle cells

Abstract : The role of the transcription factors sterol regulatory element binding protein 1a (SREBP-1a) and SREBP-1c in the regulation of cholesterol and fatty acid metabolism has been well studied; however, little is known about their specific function in muscle. In the present study, analysis of recent microarray data from muscle cells overexpressing SREBP1 suggested that they may play a role in the regulation of myogenesis. We then demonstrated that SREBP-1a and -1c inhibit myoblast-to-myotube differentiation and also induce in vivo and in vitro muscle atrophy. Furthermore, we have identified the transcriptional repressors BHLHB2 and BHLHB3 as mediators of these effects of SREBP-1a and -1c in muscle. Both repressors are SREBP-1 target genes, and they affect the expression of numerous genes involved in the myogenic program. Our findings identify a new role for SREBP-1 transcription factors in muscle, thus linking the control of muscle mass to metabolic pathways.
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https://www.hal.inserm.fr/inserm-00817651
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Virginie Lecomte, Emmanuelle Meugnier, Vanessa Euthine, Christine Durand, Damien Freyssenet, et al.. A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation.: SREBP-1a and -1c in muscle cells. Molecular and Cellular Biology, American Society for Microbiology, 2010, 30 (5), pp.1182-98. ⟨10.1128/MCB.00690-09⟩. ⟨inserm-00817651⟩

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